Electrotransport drug delivery reservoirs containing inert fillers
First Claim
1. An electrotransport agent delivery device, comprising a donor electrode, a counter electrode and a source of electrical power adapted to be electrically connected to the donor and counter electrodes, wherein the donor electrode is electrically connected to a donor reservoir having a predetermined volume (V) and being comprised of a polymeric matrix containing a predetermined quantity (q) of a therapeutic agent to be delivered, the polymeric matrix also containing an inert filler material having substantially no tendency to interact with the agent, the inert filler being present in the matrix in a form which allows electrotransport of the agent through and from the reservoir to a patient body surface, the inert filler material being present in the polymeric matrix in an amount which achieves a concentration (ρ
- ) of therapeutic agent in the matrix which exceeds q/V.
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Accused Products
Abstract
A novel electrotransport drug delivery system (10) and therapeutic agent-containing reservoir (26, 28) for use therein are provided. An inert filler material effective to reduce the quantity of therapeutic agent otherwise present is incorporated in the reservoir (26, 28) along with the therapeutic agent to be delivered via electrotransport. Methods for making the reservoir (26, 28) and drug delivery system (10) are provided as well.
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Citations
31 Claims
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1. An electrotransport agent delivery device, comprising a donor electrode, a counter electrode and a source of electrical power adapted to be electrically connected to the donor and counter electrodes, wherein the donor electrode is electrically connected to a donor reservoir having a predetermined volume (V) and being comprised of a polymeric matrix containing a predetermined quantity (q) of a therapeutic agent to be delivered, the polymeric matrix also containing an inert filler material having substantially no tendency to interact with the agent, the inert filler being present in the matrix in a form which allows electrotransport of the agent through and from the reservoir to a patient body surface, the inert filler material being present in the polymeric matrix in an amount which achieves a concentration (ρ
- ) of therapeutic agent in the matrix which exceeds q/V.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A donor reservoir for an electrotransport agent delivery device, the reservoir having a predetermined volume (V) and being comprised of a polymeric matrix containing a predetermined quantity (q) of a therapeutic agent to be delivered, the polymeric matrix also containing an inert filler material having substantially no tendency to interact with the agent, the inert filler being present in the matrix in a form which allows electrotransport of the agent through and from the reservoir to a patient body surface, the inert filler material being present in the polymeric matrix in an amount which achieves a concentration (ρ
- ) of therapeutic agent in the matrix which exceeds q/V.
- View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for increasing the volume (V) of a polymeric donor reservoir for an electrotransport delivery device, the reservoir containing a predetermined quantity (q) of the therapeutic agent to be delivered, without decreasing the concentration (ρ
- ) of the therapeutic agent in the reservoir, the method comprising placing a predetermined amount of an inert filler material in a polymer matrix, the filler material having substantially no tendency to interact with the therapeutic agent, to produce a donor reservoir comprised of a drug- and inert filler-containing polymer matrix.
Specification