Computer architecture and process of patient generation, evolution, and simulation for computer based testing system
First Claim
1. A computer implemented simulation and evaluation method for simulating interventions including active and passive intervention to a complex system, such as a patient having a set of normal and abnormal conditions such as a health state, by a user, and for evaluating the interventions responsive to predetermined criteria and the interventions, comprising the steps of:
- (a) accessing the computer implemented simulation and evaluation method by the user;
(b) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(c) selecting genetic information of the patient responsive to the test area;
(d) generating a patient history responsive to the test area and the genetic information;
(e) presenting the patient, the patient history, and at least one health state potentially requiring intervention to the user;
(f) receiving the at least one intervention including at least one of a passive intervention, an active intervention, and no intervention input by the user to apply to the patient;
(g) evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria.
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Accused Products
Abstract
A computer implemented simulation and evaluation method simulates interventions to a patient by a user, and evaluates the interventions responsive to predetermined criteria and the interventions. The method includes defining a test area to evaluate the user to at least one of predetermined criteria and a user profile, selecting genetic information of the patient responsive to the test area, and generating a patient history responsive to the test area and the genetic information. The method also includes receiving at least one intervention input by the user, and evaluating the user responsive to the intervention and predetermined criteria.
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Citations
51 Claims
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1. A computer implemented simulation and evaluation method for simulating interventions including active and passive intervention to a complex system, such as a patient having a set of normal and abnormal conditions such as a health state, by a user, and for evaluating the interventions responsive to predetermined criteria and the interventions, comprising the steps of:
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(a) accessing the computer implemented simulation and evaluation method by the user;
(b) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(c) selecting genetic information of the patient responsive to the test area;
(d) generating a patient history responsive to the test area and the genetic information;
(e) presenting the patient, the patient history, and at least one health state potentially requiring intervention to the user;
(f) receiving the at least one intervention including at least one of a passive intervention, an active intervention, and no intervention input by the user to apply to the patient;
(g) evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 34)
(h) evolving the patient responsive to the at least one intervention, the genetic information and the patient history to at least one subsequent health state; and
(i) evaluating the user responsive to the at least one intervention input by the user, the at least one subsequent health state, and the predetermined criteria.
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3. A computer implemented simulation and evaluation method according to claim 1, further comprising the steps of:
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(h) evolving the patient responsive to the at least one intervention, the genetic information and the patient history to at least one subsequent health state; and
(i) receiving at least one other intervention input by the user; and
(j) evaluating the user responsive to at least one of the at least one intervention input by the user, the at least one other intervention input by the user, the at least one subsequent health state, and the predetermined criteria.
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4. A computer implemented simulation and evaluation method according to claim 1, further comprising the steps of:
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(h) evolving the patient responsive to the at least one intervention, the genetic information and the patient history to at least one subsequent health state;
(i) receiving at least one other intervention input by the user;
(j) evolving the patient responsive to the at least one intervention, the genetic information and the patient history to at least one other subsequent health state; and
(k) evaluating the user responsive to at least one of the at least one intervention input by the user, the at least one other intervention input by the user, the at least one subsequent health state, the at least one other subsequent health state, and the predetermined criteria.
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5. A computer implemented simulation and evaluation method according to claim 1, wherein said generating step (d) further comprises the step of generating the patient history responsive to the test area, the genetic information, and an entity relationship model.
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6. A computer implemented simulation and evaluation method according to claim 5, wherein the entity relationship model comprises population, record, agents of change, health states, findings and courses of action.
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7. A computer implemented simulation and evaluation method according to claim 6, wherein the findings include specific findings, patterns and sub-patterns describing patient behaviors and characteristics.
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8. A computer implemented simulation and evaluation method according to claim 7, wherein the patterns describe one or more features over time.
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9. A computer implemented simulation and evaluation method according to claim 7, wherein the sub-patterns describe consequences of patient related events.
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10. A computer implemented simulation and evaluation method according to claim 7, wherein the patterns model time and characterize interrelated medical observations.
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11. A computer implemented simulation and evaluation method according to claim 7, further comprising the step of performing a differential diagnosis responsive to the findings, the patterns and the sub-patterns.
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12. A computer implemented simulation and evaluation method according to claim 7, wherein confidence in a presence of the patterns increases with passage of time.
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13. A computer implemented simulation and evaluation method according to claim 6, wherein the courses of action describe tasks and methods used to apply, modify, and evaluate health state information and characteristics described in the entity relationship model.
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14. A computer implemented simulation and evaluation method according to claim 6, wherein the courses of action describe patient activities, including at least one of medical and non-medical activities.
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15. A computer implemented simulation and evaluation method according to claim 6, wherein the courses of action describe potential interventions input by the user including at least one of diagnostic and management strategies.
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16. A computer implemented simulation and evaluation method according to claim 6, wherein the courses of action comprise one or more elementary courses of action used in to construct at least one course of action, one or more types of elementary courses of action corresponding to the one or more elementary course of action, and weighting factors corresponding to the one or more elementary courses of action.
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17. A computer implemented simulation and evaluation method according to claim 5, wherein the entity relationship model includes entity relations.
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18. A computer implemented simulation and evaluation method according to claim 17, further comprising the step of evolving the patient responsive to the at least one intervention, the genetic information, the entity relations and the patient history to at least one subsequent health state.
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19. A computer implemented simulation and evaluation method according to claim 5, wherein the entity relationship model includes a health states lead to health states relation describing patient evolution.
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20. A computer implemented simulation and evaluation method according to claim 5, wherein the entity relationship model includes one or more of the following relations between entities:
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Population Contacts Population Population Related to Population Population Interacts with Courses of Action Population Exposed to Agents of Change Population Has Health States Population Exhibits Findings Agents of Change Cause Health States Health States Lead to Health States Findings Associated with Health States Findings Link to Findings Course of Action use Agents of Change Courses of Action Identify Agents of Change Courses of Action Treat Health States Courses of Action Alter Findings Courses of Action Reveal Findings Courses of Action Evaluate Findings.
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21. A computer implemented simulation and evaluation method according to claim 6, wherein the entity relationship model links the findings with the patterns to a health state, rather than linking a range of finding values to the health state.
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22. A computer implemented simulation and evaluation method according to claim 6, wherein the patterns include sensitivity and specificity represented as age dependent, rather than as constants.
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23. A computer implemented simulation and evaluation method according to claim 1, wherein said generating patient history step (d) is executed once for each simulation to generate the patient history used in said computer implemented simulation and evaluation method.
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24. A computer implemented simulation and evaluation method according to claim 2, further comprising the step of repeating said evolving step (h), and said receiving step (i) a plurality of times.
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25. A computer implemented simulation and evaluation method according to claim 1, wherein said generating step (d) generates the patient history comprising a progression of health states and risk factors traversed by the patient from a normal health condition to a specified health condition.
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26. A computer implemented simulation and evaluation method according to claim 1, wherein said generating step (d) iteratively generates the patient history backwards in time from a specified health condition to a normal health condition including successive precursor health states and onset times therebetween.
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27. A computer implemented simulation and evaluation method according to claim 1, wherein said generating step (d) generates the patient history using a Monte Carlo process to multiple stochastic trees to generate a plurality of potential patient histories to be used in said computer implemented simulation and evaluation method.
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34. A computer implemented simulation and evaluation method according to claim 2, further comprising the step of repeating said evolving step (h) to the at least one subsequent health state is responsive to:
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(1) parallel health states of the patient; and
(2) a target health state and health state combinations that lead to different parallel health states.
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28. A computer implemented simulation and evaluation method for simulating interventions including active and passive intervention to a complex system, such as a patient having a set of normal and abnormal conditions such as a health state, by a user, and for evaluating the interventions responsive to predetermined criteria and the interventions, comprising the steps of:
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(a) accessing the computer implemented simulation and evaluation method by the user;
(b) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(c) selecting genetic information of the patient responsive to the test area;
(d) generating a patient history responsive to the test area and the genetic information;
(e) receiving at least one intervention input by the user; and
(f) evaluating, the user responsive to the at least one intervention input by the user and the predetermined criteria;
wherein said generating step (d) further comprises the step of generating the patient history responsive to the test area, the genetic information, and an entity relationship model; and
wherein the entity relationship model utilizes tree structures to describe a probability density function conditioned on comorbidities, treatments, risk factors, and the interventions.
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29. A computer implemented simulation and evaluation method for simulating interventions including active and passive intervention to a complex system, such as a patient having a set of normal and abnormal conditions such as a health state, by a user, and for evaluating the interventions responsive to predetermined criteria and the interventions, comprising the steps of:
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(a) accessing the computer implemented simulation and evaluation method by the user;
(b) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(c) selecting genetic information of the patient responsive to the test area;
(d) generating a patient history responsive to the test area and the genetic information;
(e) receiving at least one intervention input by the user; and
(f) evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria;
wherein said generating step (d) further comprises the step of generating the patient history responsive to the test area, the genetic information, and an entity relationship model; and
wherein the entity relationship model includes diagnostic complexities and disease interaction.
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30. A computer implemented simulation and evaluation method for simulating interventions including active and passive intervention to a complex system, such as a patient having a set of normal and abnormal conditions such as a health state, by a user, and for evaluating the interventions responsive to predetermined criteria and the interventions, comprising the steps of:
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(a) accessing the computer implemented simulation and evaluation method by the user;
(b) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(c) selecting genetic information of the patient responsive to the test area;
(d) generating a patient history responsive to the test area and the genetic information;
(e) receiving at least one intervention input by the user; and
(f) evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria;
wherein said generating step (d) further comprises the step of generating the patient history responsive to the test area, the genetic information, and an entity relationship model; and
wherein the entity relationship model includes parallel networks of health states to avoid combinatoric health state explosion. - View Dependent Claims (31, 32, 33, 35, 36)
(1) independent interaction between the parallel networks so that patient evolution between first and second parallel networks are unrelated to each other;
(2) unilateral interaction between the parallel networks so that patient evolution on a first parallel network is unrelated to the patient evolution on a second parallel network, and patient evolution on the second parallel network is related to the patient evolution on the first parallel network; and
(3) mutually dependent interaction between the parallel networks so that patient evolution between the first and second parallel networks are related to each other.
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35. A computer implemented simulation and evaluation method according to claim 30, wherein the parallel networks of health states comprise:
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(1) a primary network including primary health conditions defining a health domain;
(2) a risk factor network including risk factors for progression through the primary network; and
(3) complications attributed to treating the primary health conditions in the primary network.
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36. A computer implemented simulation and evaluation method according to claim 35, wherein the parallel networks of health states are generated using the following information:
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(1) how long at least one of the risk factors exists before influencing a transition between primary health conditions in the primary network;
(2) time required for transitions in the primary network, considering different combinations of the risk factors; and
(3) number of transitions the patient is allowed to make between a specified health state and a normal health state.
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37. A computer simulation and evaluation system for simulating interventions including active and passive intervention to a patient having a health state by a user, and for evaluating the interventions responsive to predetermined criteria and the interventions, comprising:
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a knowledge database storing patient health characteristics including at least one of population, record, agents of change, health states, findings and courses of action;
a presentation system providing access to the computer simulation and evaluation system by the user; and
a patient simulation system adapted to be connectable to said presentation system and said knowledge database, said patient simulation system performing the functions;
(a) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(b) generating a patient history responsive to the test area and the genetic information;
(c) presenting the patient, the patient history, and at least one health state potentially requiring intervention to the user;
(d) receiving the at least one intervention including at least one of a passive intervention, an active intervention, and no intervention input by the user to apply to the patient;
(e) evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria.
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38. A computer readable tangible medium storing instructions for implementing a process driven by a computer, the process simulating interventions initiated by a user, the interventions, including active and passive interventions to a patient having a health state, and the process evaluating the interventions responsive to predetermined criteria and the interventions, the instructions comprising the steps of:
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(a) accessing the computer implemented simulation and evaluation method by the user;
(b) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(c) selecting genetic information of the patient responsive to the test area;
(d) generating a patient history responsive to the test area and the genetic information;
(e) presenting the patient, the patient history, and at least one health state potentially requiring intervention to the user;
(f) receiving the at least one intervention including at least one of a passive intervention, an active intervention, and no intervention input by the user to apply to the patient;
(g) evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria.
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39. A computer implemented simulation and evaluation method simulates interventions to a patient by a user, and evaluates the interventions responsive to predetermined criteria and the interventions, said method comprising the steps of defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile, selecting genetic information of the patient responsive to the test area, generating a patient history responsive to the test area and the genetic information;
- presenting the patient, the patient history, and at least one health state potentially requiring intervention to the user, receiving the at least one intervention including at least one of a passive intervention, an active intervention, and no intervention input by the user to apply to the patient, and evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria.
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40. A computer implemented simulation and evaluation method for simulating interventions including at least one of active and passive interventions to a complex system, such as a patient having a set of normal and abnormal conditions defining at least one health state, by a user to be evaluated, and for evaluating the interventions input by the user responsive to predetermined criteria, comprising the steps of:
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(a) defining a test area to evaluate the user by the computer implemented simulation and evaluation method responsive to at least one of predetermined criteria and a user profile;
(b) selecting genetic information of the patient responsive to the test area;
(c) generating a patient history responsive to the test area, the genetic information and at least one entity relationship model including entity relations, parallel networks of health states and diagnostic complexities and disease interaction;
(d) presenting the patient, the patient history, and at least one health state potentially requiring intervention to the user;
(e) receiving the at least one intervention including at least one of a passive intervention, an active intervention, and no intervention input by the user to apply to the patient;
(f) evaluating the user responsive to the at least one intervention input by the user and the predetermined criteria. - View Dependent Claims (41, 42, 43, 44, 45)
(1) a primary network including primary health conditions defining a health domain;
(2) a risk factor network including risk factors for progression through the primary network; and
(3) complications attributed to treating the primary health conditions in the primary network.
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46. A computer implemented simulation and evaluation method for simulating interventions to a patient by a user to be evaluated, and for evaluating the interventions input by the user responsive to predetermined criteria, comprising the steps of:
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(a) defining a test area to evaluate the user responsive to at least one of predetermined criteria and a user profile;
(b) selecting genetic information of the patient responsive to the test area;
(c) generating a patient history responsive to the test area, the genetic information and at least one entity relationship model including entity relations having parallel networks of health states, diagnostic complexities and disease interaction;
(d) presenting the patient, the patient history, and at least one health state potentially requiring intervention to the user; and
(e) evaluating the user responsive to at least one intervention input by the user and the predetermined criteria. - View Dependent Claims (47, 48, 49, 50, 51)
(1) a primary network including primary health conditions defining a health domain;
(2) a risk factor network including risk factors for progression through the primary network; and
(3) complications attributed to treating the primary health conditions in the primary network.
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Specification