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Computer assisted methods for diagnosing diseases

  • US 6,248,063 B1
  • Filed: 12/22/1997
  • Issued: 06/19/2001
  • Est. Priority Date: 10/13/1994
  • Status: Expired due to Term
First Claim
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1. A computer based system for screening for a disease, prognosing a disease, diagnosing a disease, determining a presence or an absence or a severity of a disease, or a likelihood of obtaining a disease, comprising:

  • a computation station for receiving and processing a patient data file, said computation station comprising a trained neural network for processing said patient data file and producing an output value corresponding to a presence or an absence or a severity of a disease, or a likelihood of obtaining a disease, wherein said trained neural network is trained with a method comprising;

    preprocessing patient biomarkers, comprising;

    selecting patient biomarkers associated with the disease process;

    statistically and/or computationally testing discriminating power of the selected patient biomarkers individually in linear and/or non-linear combination for indicating the presence or the absence or the severity of the disease, or the likelihood of obtaining the disease;

    applying statistical, mathematical, or computational tools, and/or expert knowledge for the derivation of secondary inputs to the neural network that are linear or non-linear combinations of the original or transformed biomarkers;

    selecting only those patient biomarkers or derived secondary inputs that show discriminating power; and

    training the computer-based neural network using the preprocessed patient biomarkers or derived secondary inputs.

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