Pegs for orbital implants

• US 6,248,130 B1
• Filed: 08/03/1999
• Issued: 06/19/2001
• Est. Priority Date: 09/30/1991
• Status: Expired due to Fees

• Current Assignee: Arthur C. Perry
• Original Assignee: Arthur C. Perry
• Inventors: Perry, Arthur C.
• Primary Examiner(s): Isabella, David J
• Assistant Examiner(s): Chattopadhyay, Urmi
• Application Number:
  US09/366,447
• Time in Patent Office: 686 Days
• Field of Search: 623/6.64, 623/4.1, 427/2.24
• US Class Current: 623/6.64
• CPC Class Codes: A61F 2/141 Artificial eyes
• CPC Class Codes: Y10S 623/905 Eye

Abstract

An orbital implant motility peg capable of being placed in vivo in an orbital implant, wherein the peg is configured to permit rotation about a longitudinal axis of the peg during or following insertion of the peg into the implant, and wherein the peg comprises a means for removable attachment to an artificial eye. The means for removable attachment can comprise a convex surface capable of articulating with a concave surface on the artificial eye. The means for removable attachment can comprise a ball capable of providing a ball of a ball-and-socket articulation. The peg can contain a means for removable attachment that comprises a positive or a negative magnetic pole. The peg can define a cavity capable of containing a stint for attachment to an artificial eye. Also disclosed is a stint capable of being placed in such a peg cavity. The stint can comprise a means for removable attachment to an artificial eye such as a ball of a ball-and-socket articulation. Also disclosed are related prosthetic complexes and related methods.

Claims

1. An article for placement in the orbital cavity of a recipient, wherein said article comprises:

an orbital implant sized and configured to be used in evisceration, enucleation and/or secondary orbital implant replacement wherein said orbital implant is covered by a bioabsorbable synthetic coating.

2. The article of claim 1, wherein the orbital implant is porous.

3. The article of claim 1, wherein the orbital implant comprises hydroxyapatite.

4. The article of claim 3, wherein said implant further comprises porous low density hydroxyapatite or granular high density hydroxyapatite.

5. The article of claim 1, wherein said orbital implant comprises a material selected from the group consisting of silicone, acrylic and a combination thereof.

6. The article of claim 1, wherein said synthetic coating comprises a means for reducing an adverse immune response by a recipient.

7. The article of claims 1, wherein said synthetic coating comprises a synthetic material comprising calcium.

8. The article of claim 7, wherein said synthetic material comprises a plaster of paris (2 CaSO₄, H₂O).

9. The article of claim 1, wherein said synthetic coating is prepared by an in vitro technique.

10. The article of claim 9, wherein said in vitro technique is selected from the group consisting of cell culture, recombinant nucleic acid technology, and a combination thereof.

11. The article of claim 1, wherein said synthetic coating comprises a polymer.

12. The article of claim 11, wherein said polymer comprises a material selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, polydiox-anone, polycyanoacrylate, polyorthoester, poly (gamma-ethyl glutamate), and pseudo poly (amino acid).

13. The article of claim 11, wherein said polymer is capable for timed release of a therapeutic agent.

14. The article of claim 13, wherein said timed release of a therapeutic agent comprises degradable polymeric cross-linkages.

15. The article of claim 1, wherein said coating comprises an extracellular matrix protein.

16. The article of claim 15, wherein said extracellular matrix protein is selected from the group consisting of collagen, fibrinogen, fibronectin, and vitronectin.

17. The article of claim 1, wherein said synthetic coating comprises material coated directly onto the orbital implant.

18. The article of claim 1, wherein said synthetic coating comprises material wrapped around the orbital implant.

19. The article of claim 1, wherein said synthetic coating comprises means for allowing a more rapid vascularization of the implant.

20. The article of claim 1, wherein said coating contains apertures that define windows there through said coating.

21. The article of claim 1, wherein said article further comprises a therapeutic agent.

22. The article of claim 1, wherein said orbital implant comprises a therapeutic agent.

23. The article of claim 1, wherein said synthetic coating comprises a therapeutic agent.

24. The article of claim 21, wherein said therapeutic agent is applied as a post-operative therapy.

25. The article of claim 24, wherein said post-operative therapy administration is selected from the group consisting of orally, sublingually, topically, parenterally, and by inhalation.

26. The article of claims 1, wherein said article comprises a therapeutic agent selected from the group consisting of a vascularization agent, an antibiotic agent, an immunosuppressant, a wound-healing promoter, a blood clot dissolving agent, a blood-clotting agent, a cell adhesion modulating molecule, and any combination thereof.

27. The article of claim 26, wherein said vascularization agent is an exogenous vascularizing agent.

28. The article of claim 26, wherein said vascularization agent is selected from the group consisting of a growth factor, a serum, and a plasma.

29. The article of claim 28, wherein said growth factor is selected from the group consisting of epidermal growth factor, fibro blast growth factor, neovascular growth factor, and epithelial growth factor.

30. The article of claim 26, wherein said vascularization agent is autologous or allogeneic.

31. The article of claim 26, wherein said cell adhesion modulating molecule comprising an arginine-glycine-aspartic acid (RGD) containing compound or heparin.

32. The article of claim 1, wherein said article further comprises an artificial eye.

33. The article of claim 32, which further comprises means for coupling the artificial eye to the orbital implant.

34. The article of claim 33, wherein said means for coupling the artificial eye to the orbital implant comprises a first magnetic pole in the orbital implant and a second magnetic pole in the artificial eye, said first magnetic pole and said second magnetic pole being oppositely poled.

35. The article of claim 1, wherein said implant defines a hole.

36. The article of claim 35, wherein said article further comprises a peg having a portion sized for placement within said hole.

37. The article of claim 1, wherein said article further comprises a peg configured to be coupled to said implant.

38. The article of claim 37, wherein said peg comprises means for coupling to the artificial eye.

39. A method for preparing an article for placement into the orbital cavity of a patient, said method comprises:

forming an orbital implant sized and configured to be used in evisceration, enucleation and/or secondary orbital implant replacement; and

coating said orbital implant with a resorbable synthetic material.