Medical apparatus for the extracorporeal treatment of blood or plasma, and processes for using this apparatus
First Claim
1. Medical apparatus for the extracorporeal treatment of blood or plasma, comprising a semi-permeable membrane comprising at least one electronegative polymer, such that the surface of the semi-permeable membrane has negative electric charges, wherein the semi-permeable membrane has a negative electric charge density greater than 100 μ
- eq per ml of swollen polymer wherein, before sterilization of the apparatus, at least one cationic and anti-protease agent is incorporated in at least one part of the membrane, wherein the anti-protease agent is present in sufficient quantities to prevent activation of the kallikrein-kinin system during treatment of blood or plasma, said agent being bound in the membrane by bulk adsorption or semi-bulk adsorption and/or being bound by an ionic interaction with the electronegative sites of the membrane.
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Accused Products
Abstract
A medical apparatus for the extracorporeal treatment of blood or plasma comprises a semi-permeable membrane consisting of at least one electronegative polymer, such that the surface of the semi-permeable membrane has negative electric charges. Before the sterilization of the apparatus, and before or after the formation of the membrane, at least one cationic and anti-protease agent is incorporated in at least one part of the membrane, this agent undergoing bulk adsorption or semi-bulk adsorption in the membrane and/or being bound by an ionic interaction with the electronegative sites of the membrane.
57 Citations
17 Claims
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1. Medical apparatus for the extracorporeal treatment of blood or plasma, comprising a semi-permeable membrane comprising at least one electronegative polymer, such that the surface of the semi-permeable membrane has negative electric charges, wherein the semi-permeable membrane has a negative electric charge density greater than 100 μ
- eq per ml of swollen polymer wherein, before sterilization of the apparatus, at least one cationic and anti-protease agent is incorporated in at least one part of the membrane, wherein the anti-protease agent is present in sufficient quantities to prevent activation of the kallikrein-kinin system during treatment of blood or plasma, said agent being bound in the membrane by bulk adsorption or semi-bulk adsorption and/or being bound by an ionic interaction with the electronegative sites of the membrane.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 13)
- 11. In a method of conducting hemodialysis in a medical apparatus, the improvement comprising conducting hemodialysis with a medical apparatus so as to prevent activation of the kallikrein-kinin system said medical apparatus being in sterilized form and comprising a semi-permeable membrane comprising at least one electronegative polymer, such that the surface of the semi-permeable membrane has negative electric charges, this apparatus being characterized in that, before sterilization of the apparatus, at least one cationic and anti-protease agent is incorporated in at least one part of the membrane, wherein the anti-protease agent is present in sufficient quantities to prevent activation of the kallikrein-kinin system during treatment of blood or plasma, said agent being bound in the membrane by bulk adsorption or semi-bulk adsorption and/or being bound by an ionic interaction with the electronegative sites of the membrane.
Specification