Therapeutic antimicrobial compositions

• US 6,248,343 B1
• Filed: 12/13/1999
• Issued: 06/19/2001
• Est. Priority Date: 01/20/1998
• Status: Expired due to Term

• Current Assignee: Schulke & Mayr GmbH
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Jampani, Hanuman B., Ellis, Timothy, Newman, Jerry L.
• Primary Examiner(s): Dodson, Shelley A.
• Assistant Examiner(s): Lamm, Marina
• Application Number:
  US09/460,031
• Time in Patent Office: 554 Days
• Field of Search: 424/401, 424/405, 424/195.1, 514/635, 514/642, 514/724, 514/828, 514/859, 514/944
• US Class Current: 424/405
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/04 Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/10 Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/40 having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
• CPC Class Codes: A01N 39/00 Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• CPC Class Codes: A01N 47/12 containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
• CPC Class Codes: A01N 47/36 containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
• CPC Class Codes: A01N 47/38 containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
• CPC Class Codes: A01N 57/12 containing acyclic or cycloaliphatic radicals
• CPC Class Codes: A01N 65/00 Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof containing compounds of determined constitution A01N27/00 - A01N59/00
• CPC Class Codes: A01N 65/08 Magnoliopsida [dicotyledons]
• CPC Class Codes: A01N 65/22 Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
• CPC Class Codes: A01N 65/28 Myrtaceae [Myrtle family], e.g. teatree or clove
• CPC Class Codes: A01N 65/32 Ranunculaceae [Buttercup family], e.g. hepatica, hydrastis or goldenseal
• CPC Class Codes: A01N 65/40 Liliopsida [monocotyledons]
• CPC Class Codes: A01N 65/44 Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
• CPC Class Codes: A01N 65/48 Zingiberaceae [Ginger family], e.g. ginger or galangal
• CPC Class Codes: A61K 2300/00 : Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 : Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/09 : having two or more such linkages
• CPC Class Codes: A61K 31/14 : Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 36/185 : Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/53 : Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 36/61 : Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 36/71 : Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
• CPC Class Codes: A61K 36/88 : Liliopsida (monocotyledons)
• CPC Class Codes: A61K 36/899 : Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• CPC Class Codes: A61K 36/9066 : Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 8/347 : Phenols
• CPC Class Codes: A61K 8/416 : Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin

Abstract

Antimicrobial alcohol-containing compositions and methods of using the compositions to disinfect surfaces and provide therapeutic benefits are disclosed.

Claims

1. An antimicrobial composition comprising:

a) an antimicrobial selected from the group consisting of greater than 30% by volume alcohol, an effective amount of triclosan and mixtures thereof; and

b) an effective amount of phenoxy ethanol, benzalkonium chloride or benzethonium chloride, and cocophosphatidyl-dimonium chloride; and

c) an effective amount of naturally occurring plant or plant extract.

2. The composition of claim 1 wherein the alcohol is selected from the group consisting of ethyl alcohol, iso-propyl alcohol and n-propyl alcohol and mixtures thereof.

3. The composition of claim 1 wherein the phenoxy ethanol is from about 0.25 to about 5.0 percent by weight;

the benzalkonium chloride is from about 0.02 to about 1.0 percent by weight; and

the cocophosphatidyl-dimonium chloride is from about 0.01 to about 1.0 percent by weight.

4. The composition of claim 1 wherein the naturally occurring plant or extract thereof is selected from the group consisting of curcuma longa, croccus sativus (saffron), alkanna tinctoria (henna root), hydrastis canadensis and mixtures thereof.

5. The composition of claim 4 wherein the amount of plant or plant extract is from about 0.1 to about 10 percent by weight based on individual plant or plant extract.

6. The composition of claim 1 which additionally contains an effective amount of diazolidinyl urea and 3-Iodo-propynylbutylcarbamate.

7. The composition of claim 6 wherein the total amount of diazolidinyl urea and 3-Iodo-propynylbutylcarbamate is from about 0.05 to about 0.5 percent by weight.

8. The composition of claim 6 which additionally contains an effective amount;

methyl paraben, propyl paraben, and propylene glycol.

9. The composition of claim 8 wherein the total amount of diazolindinyl urea, methyl parabeni propyl paraben, and propylene glycol is from about 0.05 to about 0.5 percent by weight.

10. The composition of claim 1 which additionally contains an effective amount of cocamidopropyl phosphatidyl dimonium chloride.

11. The composition of claim 10 wherein the amount of cocamidopropyl phosphatidyl dimonium chloride is from about 0.01 to about 1.0 percent by weight.

12. A method of disinfecting a substrate comprising the step of applying to the substrate an effective amount of the antimicrobial composition of claim 1.

13. The method of claim 12 wherein the substrate is the hand.

15. A method for controlling skin inflammations and bacterial infections comprising topical administration to the skin an anti-inflammatory effective amount of the composition according to claim 4.

17. A method for controlling skin inflammations and bacterial infections selected from the group consisting of acne, skin lesions, pseudofolliculitis, local redness, local pain, local odor, and increased exudate comprising topical administration to the skin an anti-inflammatory effective amount of the composition of claim 4.

20. The composition of claim 1 which additionally contains an effective amount of an essential oil selected from the group consisting of Australian tea tree oil, lemongrass oil, thyme oil lavender oil and clove oil.

21. The composition of claim 2 which additionally contains an effective amount of an essential oil selected from the group consisting of Australian tea tree oil, lemongrass oil, thyme oil lavender oil and clove oil.

22. The composition of claim 1 which additionally contains an effective amount of octanoyl collagenic acid and cetyl pyridinium chloride, and polyhexamethylene biguanide.

14. A method for controlling intact and broken skin inflammations including local redness, local pain, local odour, increased exudate, and bacterial infections comprising topical administration to the skin an anti-inflammatory effective amount of the composition comprising:

a) an antimicrobial selected from the group consisting of greater than 30% by volume alcohol, an effective amount of triclosan and mixtures thereof;

b) an effective amount of phenoxy ethanol, benzalkonium chloride or benzethonium chloride, and cocophosphatidyl-dimonium chloride; and

c) an effective amount of naturally occuring plant or plant extract.

16. A method for controlling skin inflammations and bacterial infections selected from the group consisting of acne, skin lesions, pseudofolliculitis, local redness, local pain, local odor, and increased exudate comprising topical administration to the skin an anti-inflammatory effective amount of the composition comprising:

a) an antimicrobial selected from the group consisting of greater than 30% by volume alcohol, an effective amount of triclosan and mixtures thereof;

b) an effective amount of phenoxy ethanol, henzalkonium chloride or benzethonium chloride, and cocophosphatidyl-dimonium chloride, and

c) an effective amount of naturally occurring plant or plant extract.

18. A gel comprising an effective amount of a, alcohol, an effective amount of phenoxy ethanol, benzalkonium chloride, cocophosphatidyl-dimonium chloride, and a naturally occurring plant or plant extract.

19. The gel of claim 18 wherein the naturally occurring plant or plant extract is selected from the group consisting of curcuma longa, croccus sativus (saffron), alkanna tinctoria (henna root), hydrastis canadensis and mixtures thereof.