Hypertonia gene

• US 6,248,873 B1
• Filed: 02/05/1999
• Issued: 06/19/2001
• Est. Priority Date: 04/04/1996
• Status: Expired due to Fees

• Current Assignee: Progen Biotechnik
• Original Assignee: Progen Biotechnik GmbH (RMD Holding GmbH)
• Inventors: Luft, Friedrich, Schuster, Herbert, Wienker, Thomas, Bähring, Sylvia, Bilginturan, Nihat
• Primary Examiner(s): CARLSON, KAREN C
• Application Number:
  US09/155,756
• Time in Patent Office: 865 Days
• Field of Search: 536/23.1
• US Class Current: 536/23.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C07K 14/575 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin C07K14/665, e.g. corticotropin C07K14/695
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers

Abstract

The present invention relates to a hypertonia gene located on chromosome 12p in the genomic region between genome markers AFM338WH5 and D12S1057 and uses of such a gene.

Claims

1. An isolated hypertonia gene, wherein the gene is located on chromosome 12p in the genomic region between genome markers AFM338WH5 and D12S1057.

2. The gene according to claim 1, wherein the genomic region comprises sequences of the overlapping YAC clones DSM 10619, DSM 10620, DSM 10621, DSM 10622, DSM 10623, DSM 10624, DSM 10625, DSM 10626, DSM 10627, DSM 10628, DSM 10629, and DSM 10630.

3. The gene according to claim 1 or 2, wherein that the genomic region comprises sequences of the overlapping YAC clones DSM 10619, DSM 10620, DSM 10621, DSM 10624, DSM 10625, DSM 10627, DSM 10628, and DSM 10629.

4. The gene according to claim 1 or 2, wherein the genomic region comprises sequences of the overlapping YAC clones DSM 10619 and DSM 10621.

5. The gene according to claim 1 or 2, wherein the genomic region comprises sequences of the YAC clone DSM 10621.