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Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control

  • US 6,251,129 B1
  • Filed: 12/16/1998
  • Issued: 06/26/2001
  • Est. Priority Date: 03/24/1998
  • Status: Expired due to Term
First Claim
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1. A method for substantially reducing the size of a thrombus in a blood vessel in which blood is flowing, comprising:

  • delivering a heat transfer element to a blood vessel in fluid communication with a thrombosed blood vessel;

    adjusting the temperature of the heat transfer element such that the temperature of the heat transfer element is sufficient to remove heat from the flowing blood; and

    transferring heat from a volume including the thrombus to the heat transfer element, such that the resultant temperature of the volume is sufficient to substantially reduce the size of a thrombus.

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