Implantation device and a kit including the device

• US 6,251,142 B1
• Filed: 12/09/1997
• Issued: 06/26/2001
• Est. Priority Date: 12/10/1996
• Status: Expired due to Term

• Current Assignee: CID S.p.A (Alvimedica ApS)
• Original Assignee: Sorin Biomedica Cardio Srl (LivaNova Plc)
• Inventors: Ciana, Leopoldo Della, Bernacca, Giuliana, Massaglia, Anilla, Curcio, Maria
• Primary Examiner(s): Willse, David H.
• Assistant Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US08/987,365
• Time in Patent Office: 1,295 Days
• Field of Search: 623/1, 623/12, 623/1.42, 623/1.43, 623/1.46, 623/1.48, 623/1.47, 623/23.57, 435/181, 427/2--, 427/2.34
• US Class Current: 623/23.57
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

The apparatus comprises an implantation device having a body, the surface of which has at least a portion coated with a receptor, and a preparation containing a ligand formed from the combination of an active principle with a substance capable of binding to the receptor. This preparation may be brought into contact when desired with the implantation device which is, for example, a stent.

Claims

1. A method of administering an active principle at a desired location in the body of a patient comprising:

providing an implantation device;

coating the implantation device with a receptor;

providing a preparation containing a ligand comprising an active principle combined with a substance capable of binding with the receptor;

implanting the receptor coated implantation device at the desired location in the patient'"'"'s body; and

exposing the implantation device to the preparation containing the ligand in order to form a bond between the ligand and the receptor after the implantation device has been implanted in the patient'"'"'s body.

2. The method of claim 1 wherein the provided implantation device has a body with a surface and wherein the method further comprises treating the surface of the body of the implantation device by bringing the surface into contact with at least one of an oxidizing solution, an oxidizing gas, and a plasma prior to coating the implantation device with the receptor.

3. The method of claim 2 wherein the step of treating the surface of the body of the implantation device comprises an ammoniacal plasma treatment.

4. The method of claim 1 wherein the provided implantation device has a body with a surface and wherein the method further comprises treating the surface of the body of the implantation device by bringing the surface into contact with a substance capable of attaching to the surface and forming an anchorage site for the receptor prior to coating the implantation device with the receptor.

5. The method of claim 1 wherein the step of exposing the implantation device to the preparation containing the ligand comprises administering the preparation percutaneously into the patient'"'"'s body.

6. The method of claim 1 wherein the step of exposing the implantation device to the preparation containing the ligand comprises administering the preparation transdermally into the patient'"'"'s body.

7. The method of claim 1 wherein the step of exposing the implantation device to the preparation containing the ligand comprises administering the preparation systemically into the patient'"'"'s body.

8. The method of claim 1 wherein the step of providing the preparation containing the ligand comprises selecting the preparation such that the ligand comprises an active principle desirable for administration to the patient based upon the patent'"'"'s needs.

9. A method of administering an active principle at a desired location in the body of a patient comprising:

providing an implantation device;

coating the implantation device with a receptor;

providing a preparation containing a ligand comprising an active principle combined with a substance capable of binding with the receptor;

placing the receptor coated implantation device in a package;

sterilizing the receptor coated implantation device;

removing the sterilized receptor coated implantation device from the package prior to implantation;

implanting the sterilized receptor coated implantation device at the desired location in the patient'"'"'s body; and

exposing the implantation device to the preparation containing the ligand after the sterilized receptor coated implantation device has been removed from the package in order to form a bond between the ligand and the receptor.

10. The method of claim 9 wherein the provided implantation device has a body with a surface and wherein the method further comprises treating the surface of the body of the implantation device by bringing the surface into contact with at least one of an oxidizing solution, an oxidizing gas, and a plasma prior to coating the implantation device with the receptor.

11. The method of claim 9 wherein the step of treating the surface of the body of the implantation device comprises an ammoniacal plasma treatment.

12. The method of claim 9 wherein the provided implantation device has a body with a surface and wherein the method further comprises treating the surface of the body of the implantation device by bringing the surface into contact with a substance capable of attaching to the surface and forming an anchorage site for the receptor prior to coating the implantation device with the receptor.

13. The method of claim 9 wherein the step of exposing the implantation device to the preparation containing the ligand occurs before the step of implanting.

14. The method of claim 9 wherein the step of exposing the implantation device to the preparation containing the ligand occurs after the step of implanting.

15. The method of claim 13 wherein the step of exposing the implantation device to the preparation containing the ligand comprises administering the preparation percutaneously into the patient'"'"'s body.

16. The method of claim 13 wherein the step of exposing the implantation device to the preparation containing the ligand comprises administering the preparation transdermally into the patient'"'"'s body.

17. The method of claim 13 wherein the step of exposing the implantation device to the preparation containing the ligand comprises administering the preparation systemically into the patient'"'"'s body.

18. The method of claim 9 wherein the step of providing the preparation containing the ligand comprises selecting the preparation such that the ligand comprises an active principle desirable for administration to the patient based upon the patent'"'"'s needs.