Imprint-coating synthesis of selective functionalized ordered mesoporous sorbents for separation and sensors
First Claim
1. A process for the preparation of an ordered mesoporous sorbent comprising:
- (a) mixing an imprint coating precursor and an ordered mesoporous substrate to form a coated mesoporous substrate wherein the imprint coating precursor comprises a template molecule bound to one end of more than one bifunctional ligand;
(b) treating the coated mesoporous substrate with an acid solution;
(c) evaporating the mixture; and
(d) titrating the coated mesoporous substrate to a neutral pH to form the ordered mesoporous sorbent.
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Abstract
The present invention relates generally to mesoporous sorbent materials having high capacity, high selectivity, fast kinetics, and molecular recognition capability. The invention also relates to a process for preparing these mesoporous substrates through molecular imprinting techniques which differ from convention techniques in that a template molecule is bound to one end of bifunctional ligands to form a complex prior to binding of the bifunctional ligands to the substrate. The present invention also relates to methods of using the mesoporous sorbent materials, for example, in the separation of toxic metals from process effluents, paints, and other samples; detection of target molecules, such as amino acids, drugs, herbicides, fertilizers, and TNT, in samples; separation and/or detection of substances using chromatography; imaging agents; sensors; coatings; and composites.
268 Citations
53 Claims
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1. A process for the preparation of an ordered mesoporous sorbent comprising:
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(a) mixing an imprint coating precursor and an ordered mesoporous substrate to form a coated mesoporous substrate wherein the imprint coating precursor comprises a template molecule bound to one end of more than one bifunctional ligand;
(b) treating the coated mesoporous substrate with an acid solution;
(c) evaporating the mixture; and
(d) titrating the coated mesoporous substrate to a neutral pH to form the ordered mesoporous sorbent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
(a) mixing an ammonium halide, water, and a base;
(b) adding a metal alkoxide to the mixture;
(c) heating the mixture to a temperature of about 60°
C. to about 80°
C. for about 14 hours to about 20 hours; and
(d) recovering the solid, ordered mesoporous substrate.
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11. The process of claim 10 wherein the ammonium halide is selected from the group consisting of cetyltrimethylammonium bromide and cetyltrimethylammonium chloride.
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12. The process of claim 10 wherein the base is selected from the group consisting of sodium hydroxide, ammonium hydroxide, lithium hydroxide, potassium hydroxide, calcium hydroxide, and magnesium hydroxide.
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13. The process of claim 10 wherein the metal alkoxide is selected from the group consisting of a silicate, a titanate, and a zirconate.
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14. The process of claim 13 wherein the silicate is selected from the group consisting of tetraethylorthosilicate, tetramethylorthosilicate, and tetrabutylorthosilicate.
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15. The process of claim 13 wherein the titanate is selected from the group consisting of tetraethylorthotitanate, tetra-tert-butylorthotitanate, tetraisopropylorthotitanate, tetrabutylorthotitanate, and tetrapropylorthotitanate.
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16. The process of claim 13 wherein the zirconate is selected from the group consisting of tetrapropylzirconate, zirconium (IV) tert-butoxide, zirconium (IV) butoxide, zirconium (IV) isopropoxide.
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17. The process of claim 1 wherein the acid is a mineral acid.
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18. The process of claim 17 wherein the mineral acid is selected from the group consisting of nitric acid, sulfuric acid, and hydrochloric acid.
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19. The process of claim 1 wherein the solvent is selected from the group consisting of water, a protic solvent, and dimethyl sulfoxide.
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20. The process of claim 19 wherein the protic solvent is selected from the group consisting of methanol, ethanol, and propanol.
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21. The process of claim 1 wherein the coated mesoporous substrate is titrated with a base.
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22. The process of claim 21 wherein the base is selected from the group consisting of sodium hydroxide, ammonium hydroxide, lithium hydroxide, potassium hydroxide, calcium hydroxide, and magnesium hydroxide.
- 23. An ordered mesoporous sorbent comprising bifunctional ligands bound to the surface of an ordered mesoporous substrate wherein the mesoporous substrate contains concave porous surfaces and the bifunctional ligands are bound to form tailored binding pockets for a target molecule wherein the tailored binding pocket is formed from a template molecule bound to one end of more than one bifunctional ligand.
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34. An ordered mesoporous sorbent prepared by the process comprising:
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(a) mixing an imprint coating precursor and an ordered mesoporous substrate to form a coated mesoporous substrate wherein the imprint coating precursor comprises a template molecule bound to one end of more than one bifunctional ligand;
(b) treating the coated mesoporous substrate with an acid solution;
(c) evaporating the mixture; and
(d) titrating the coated mesoporous substrate to a neutral pH to form the ordered mesoporous sorbent. - View Dependent Claims (35, 36, 37)
(a) mixing an ammonium halide, water, and a base;
(b) adding a metal alkoxide to the mixture;
(c) heating the mixture to a temperature of about 60°
C. to about 80°
C. for about 14 hours to about 20 hours; and
(d) recovering the solid, ordered mesoporous substrate.
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Specification