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Methods for diagnosing sepsis

  • US 6,251,598 B1
  • Filed: 10/30/1998
  • Issued: 06/26/2001
  • Est. Priority Date: 10/30/1998
  • Status: Expired due to Fees
First Claim
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1. A method for predicting the severity with which an infected subject is likely to develop sepsis, said method comprising the steps of:

  • a) obtaining a nucleic acid sample from the subject; and

    b) detecting at least one allele in linkage disequilibrium with IL-1B (-511) allele 2 in said sample;

    wherein said at least one allele is located in the promoter of the IL-1B gene and wherein detection that the sample is homozygous for said at least one allele indicates that the subject is likely to develop severe sepsis.

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