System for optimized brain stimulation

• US 6,253,109 B1
• Filed: 11/05/1998
• Issued: 06/26/2001
• Est. Priority Date: 11/05/1998
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gielen, Frans L. H.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/186,490
• Time in Patent Office: 964 Days
• Field of Search: 607/2, 607/45, 607/48, 607/76, 607/115, 607/116, 600/373, 600/378, 600/544, 600/545
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36153 Voltage A61N1/3616 takes precedence
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

There is provided apparatus and a method for testing to optimally place a deep brain lead, particularly for stimulating the GPi or other deep brain target to treat neurological disorders such as Parkinson'"'"'s Disease and the like. The invention embraces determining the location of a feedback target such as the motor cortex, the location of the deep brain target, and inserting a test lead along a substantially linear trajectory so as to be able to stimulate both concurrently. The test lead has an electrode at about its distal end for stimulation of the deep brain target, and an electrode adjustably positioned 3-8 cm proximal for stimulation of the motor cortex. When stimulation is applied concurrently through both electrodes, the affected body portion, e.g., limb, can be made to move when and if the deep brain electrode is optimally positioned. The position can be checked during surgical implant of the system, and the lead position adjusted until the optimum position is found. By use of this invention, the best lead position for the permanently implanted lead can be determined during the surgical procedure.

Claims

1. A brain stimulation system, comprising a brain stimulator device and lead means for placement of electrodes at predetermined positions within a patient'"'"'s brain,

said brain stimulator device having first pulse means for generating feedback pulses for stimulating a feedback target in the patient'"'"'s brain and second pulse means for generating DBS pulses for stimulating a neuro-modulation target in said patient'"'"'s brain;

and

lead means connected to said device for conducting said pulses from said device to said respective targets, said lead means comprising a DBS electrode and a conductor for conducting said DBS pulses from said second pulse means to said DBS electrode, a feedback electrode and a conductor for connecting said feedback pulses from said first pulse means to said feedback electrode, and said DBS and feedback electrodes being positioned on said lead means relative to each other so that when said DBS electrode is positioned at said neuro-stimulation target said feedback electrode is positioned at said feedback target.

2. The system as described in claim 1, wherein said lead means is a single lead, and said DBS electrode is positioned near the lead distal end and said feedback electrode is positioned about 3-8 cm from said DBS electrode, whereby said lead can be inserted into the patient'"'"'s brain along a predetermined path to position said electrodes at said respective feedback and neuro-modulation targets.

3. The system as described in claim 2, wherein said lead comprises adjusting means for adjusting the position of said feedback electrode to be positioned at the patient'"'"'s motor cortex when said DBS electrode is positioned at said patient'"'"'s GPi.

4. The system as described in claim 3, wherein said lead has a lead body, and said adjusting means comprises a slidable tubing having a window, said tubing being slidable over said lead body to expose said feedback electrode at a desired position relative to the motor cortex.

5. The system as described in claim 4, wherein said feedback electrode has an effective surface area larger than the area of said window.

6. The system as described in claim 1, wherein said first pulse means comprises MC generator means for generating pulses at a rate of about 1-5 Hz for delivery to the patient'"'"'s motor cortex, and parameter means for controlling said generated pulses to have a duration of about 1-10 ms and a voltage of about 1-10 volts.

7. The system as described in claim 1, wherein said second pulse means comprises DBS target means for generating pulses at a rate of about 50-250 Hz, and parameter means for controlling generation of said pulses to have a duration in the range of about 60-120 μ

S and a voltage in the range of about 1-10 volts.

8. The system as described in claim 1, wherein said brain stimulator device further comprises means for receiving signals from at least one of said electrodes and means for recording such signals.