Intra-coronary radiation devices containing Ce-144 or Ru-106

• US 6,254,552 B1
• Filed: 10/01/1998
• Issued: 07/03/2001
• Est. Priority Date: 10/03/1997
• Status: Expired due to Fees

• Current Assignee: Lantheus Medical Imaging, Inc. (Lantheus Holdings, Inc.)
• Original Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Inventors: Lewis, Robert E., Walsh, Paul R., Singh, Prahlad R., Tercho, Gerald P.
• Primary Examiner(s): Gilbert, Samuel G.
• Application Number:
  US09/164,730
• Time in Patent Office: 1,006 Days
• Field of Search: 600/1-8
• US Class Current: 600/3
• CPC Class Codes: A61K 51/1282 Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
• CPC Class Codes: A61N 2005/1025 Wires
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy
• CPC Class Codes: Y10S 977/949 Radiation emitter using nanostructure

Abstract

An intra-coronary radiation devices containing Ce-144 or Ru-106 deposited onto a wire and coated with a biocompatible material and methods of making and using the same.

Claims

1. A device for intra-coronary radiation therapy, comprising;

(a) a wire;

(b) a radiation source deposited or absorbed onto the wire, wherein the radiation source is Ce-144 or Ru-106; and

,

(c) a first biocompatible material scaling the radiation and wire.

2. A device according to claim 1, wherein the radiation source is Ru-106.

3. A device according to claim 1, wherein the radiation source is Ce-144.

4. A device according to claim 1, wherein the wire is metal and is selected from:

zirconium, titanium, aluminum, nickel, copper, graphite wire, 304 stainless steel or copper plated stainless steel.

5. A device according to claim 4, wherein the wire is 304 stainless steel or copper plated stainless steel.

6. A device according to claim 1, wherein the first biocompatible material is selected from:

polyimide, polyamide, polyvinyl chloride, gold, nickel, and heat shrink tubing.

7. A device according to claim 6, wherein the first biocompatible material is heat shrink tubing.

8. A device according to claim 7, wherein the first biocompatible material is polyethylene terephthalate.

9. A device according to claim 1, wherein a second biocompatible material encapsulates the intra-coronary radiation device attached to the guide wire.

10. A device according to claim 9, wherein the second biocompatible material is heat shrink tubing.

11. A device according to claim 10, wherein the second biocompatible material is polyethylene terephthalate.

23. An apparatus for intra-coronary radiation therapy comprising a device according to claim 1 and a guide wire, wherein the device is attached to the guide wire, and the guide wire is capable of being inserted into a catheter.

12. A device for intra-coronary radiation therapy, comprising:

(a) a wire, wherein the wire is an extruded wire, comprising;

(ai) a radiation source selected from Ce-144 and Ru-106; and

,

(aii) a metal selected from copper, aluminum, sliver, gold and nickel.

13. A device according to claim 12, wherein the radiation source is Ce-144 and the metal is aluminum.

14. A process for making an intra-coronary radiation device, comprising:

(a) depositing a radioactive source onto a metal wire segment, wherein the radioactive source is Ce-144 or Ru-106; and

,

(b) sealing the deposited radioactive source with a first biocompatible material.

15. A process according to claim 14, wherein the radiation source is Ru-106.

16. A process according to claim 14, the radiation source is Ce-144.

17. A process according to claim 14, wherein the radioactive source is deposited onto the metal wire by electrolytic means.

18. A process according to claim 14, wherein the radioactive source is deposited onto the metal wire by an oxidative-reductive process.

19. A process for making an intra-coronary radiation device, comprising;

(a) absorbing a radioactive source onto a metal wire segment, wherein the radioactive source is Ce-144 or Ru-106; and

;

(b) sealing the deposited radioactive source with a first biocompatible material.

20. A device for intra-coronary radiation therapy, prepared by the process comprising the steps of:

(a)

(b) depositing, or absorbing, a radiation source onto a wire, wherein the radiation source is Ce-144 or Ru-106; and

(c) sealing the radiation source and wire with a first biocompatible material.

21. A new device according to claim 20, wherein depositing the radiation source is by electrolytic means.

22. A device according to claim 20, wherein depositing the radiation source is by an oxidative-reductive process.