Intracardiac drug delivery device utilizing spring-loaded mechanism

• US 6,254,573 B1
• Filed: 08/26/1999
• Issued: 07/03/2001
• Est. Priority Date: 02/05/1998
• Status: Expired due to Term

• Current Assignee: Biosense, Inc. (Cardinal Health, Inc.)
• Original Assignee: Biosense, Inc. (Cardinal Health, Inc.)
• Inventors: Matcovitch, Avraham, Yaron, Uri, Haim, Shlomo Ben
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/383,890
• Time in Patent Office: 677 Days
• Field of Search: 604/131, 604/134, 604/135, 604/136, 604/137, 604/156, 604/157, 604/523, 604/21, 607/120, 607/122, 600/508, 600/513
• US Class Current: 604/157
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61M 2025/0076 Unidirectional valves
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61M 25/0075 Valve means
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0084 being one or more injection needles

Abstract

An apparatus for intracardiac drug administration of a therapeutic drug comprises a catheter having a distal end and a drug delivery device which is driveable from the distal end. The drug delivery device includes a needle and a spring-loaded mechanism operatively connected to the needle. The spring-loaded mechanism drives the needle out of the distal end of the catheter upon administering of the therapeutic drug. The spring-loaded mechanism returns the needle within the distal end of the catheter after the administering of the therapeutic drug.

Claims

1. An apparatus for intracardiac drug administration of a therapeutic drug comprising:

a catheter having a distal end and a drug delivery device driveable from said distal end, said catheter including at least one position sensor which generates position sensor signals responsive to the position of said catheter within a heart, said position sensor signals being used to generate position and orientation coordinates; and

said drug delivery device including a needle and a spring-loaded mechanism operatively connected to said needle, said spring-loaded mechanism driving said needle out of said distal end of said catheter upon administering of said therapeutic drug and said spring-loaded mechanism returning said needle within said distal end of said catheter after said administering of said therapeutic drug.

2. The apparatus according to claim 1, further comprising a therapeutic drug, wherein the therapeutic drug comprises a growth factor.

3. Apparatus according to claim 1, further comprising a therapeutic drug, wherein the therapeutic drug comprises a liquid compound.

4. Apparatus according to claim 1, further comprising a therapeutic drug, wherein the therapeutic drug comprises a soluble compound.

5. Apparatus according to claim 1, further comprising a therapeutic drug, wherein the therapeutic drug comprises a gene encoding a growth factor.

6. Apparatus according to claim 1, further comprising a therapeutic drug, wherein the therapeutic drug comprises naked DNA.

7. Apparatus according to claim 6, wherein the therapeutic drug comprises plasmid DNA.

8. Apparatus according to claim 1, further comprising a therapeutic drug, wherein the therapeutic drug comprises an adenoviral vector.

9. Apparatus according to claim 2, wherein the growth factor comprises a vascular endothelial growth factor (VEGF).

10. Apparatus according to claim 2, wherein the growth factor comprises a fibroblast growth factor (FGF).