Method of treating huntington's disease using HNT neurons

• US 6,254,865 B1
• Filed: 06/17/1998
• Issued: 07/03/2001
• Est. Priority Date: 06/17/1997
• Status: Expired due to Fees

• Current Assignee: University Technology Corporation
• Original Assignee: University Technology Corporation
• Inventors: Kaddis, Farida G., Freed, Curt R.
• Primary Examiner(s): Clark, Deborah J. R.
• Assistant Examiner(s): Wilson, Michael C.
• Application Number:
  US09/099,121
• Time in Patent Office: 1,112 Days
• Field of Search: 424/93.1, 424/93.7, 514/44
• US Class Current: 424/93.7
• CPC Class Codes: A01K 67/0271 Chimeric vertebrates, e.g. comprising exogenous cells
• CPC Class Codes: A61K 2035/126 Immunoprotecting barriers, e.g. jackets, diffusion chambers
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: C12N 2510/00 Genetically modified cells
• CPC Class Codes: C12N 5/0619 Neurons

Abstract

The present invention relates to methods and compositions for transplantation of neurons. The methods and compositions of the present invention provide a renewable supply of safe and effective therapeutic transplantable tissue. In particular, the present invention provides methods and compositions for the transplantation of terminally differentiated neurons derived from cell lines for the treatment of Huntington'"'"'s disease and other neurological disorders.

Claims

1. A method of improving the motor skills of an individual with Huntington'"'"'s disease comprising providing a plurality of hNT neurons into the corpus striatum of an individual with Huntington'"'"'s disease such that the motor skills of the individual with Huntington'"'"'s disease are improved.

2. The method of claim 1, wherein the individual is a human.