Sensors for continuous monitoring of biochemicals and related method
First Claim
1. A sensor unit for sensing properties of a sample analyte and to be used with remote detection means, said sensor unit comprisinga capsule defining a processing chamber, at least a portion of said capsule being a semi-permeable membrane, which is permeable to said analyte, receptor material disposed within said chamber and capable of chemically interacting with said analyte, said sensor unit further comprises a pH indicator within said sensor unit, and said pH indicator being of such size that diffusion of said pH indicator out of said chamber is resisted by said semi-permeable membrane.
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Accused Products
Abstract
Apparatus and method for measuring properties of certain analytes are provided. The apparatus includes a sensor capsule having a processing chamber defined by a wall which in one embodiment has a semi-permeable membrane permeable to the analyte as at least a portion thereof. Receptor material is disposed within the chamber and is capable of chemically interacting with the analyte. In one embodiment, at least a portion of the sensor is translucent. A light source, which may be an optical fiber, causes light to impinge on a translucent portion of the capsule and pass therethrough. Responsive fluorescent light is generated and emitted. This light may be received by detector means and processed in a conventional manner to determine concentration of the analyte. A dye-labelled analog-analyte may be provided within the chamber. Both the receptor material and analog-analyte are of such size that they will not pass through the semi-permeable membrane although the analyte can. The invention is particularly suited to use of the capsule as an implantable element which is physically separated from the light source and detector and can be placed underneath the skin. In another embodiment, a receptor reagent and a receptor are covalently bonded to a stable polymer structure and a semi-permeable membrane is not required.
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Citations
4 Claims
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1. A sensor unit for sensing properties of a sample analyte and to be used with remote detection means, said sensor unit comprising
a capsule defining a processing chamber, at least a portion of said capsule being a semi-permeable membrane, which is permeable to said analyte, receptor material disposed within said chamber and capable of chemically interacting with said analyte, said sensor unit further comprises a pH indicator within said sensor unit, and said pH indicator being of such size that diffusion of said pH indicator out of said chamber is resisted by said semi-permeable membrane.
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3. A system for sensing properties of an analyte comprising
a sensor capsule having a processing chamber defined by a wall which has a semi-permeable membrane permeable to said analyte as at least a portion thereof, receptor material disposed within said chamber and being capable of chemically interacting with said analyte, at least a portion of said sensor wall being translucent, and electric sensor means for positioning on the skin in relatively close proximity to said sensor capsule for monitoring electrical properties of said analyte.
Specification