Method of diagnosis and treatment and related compositions and apparatus
First Claim
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1. A method of operating a titration system for the treatment of chronic noncardiac diseases comprising vasospasm or other symptom alleviatable by smooth muscle relaxation, said system comprising a flow device and a dosage device and said method comprising in combination:
- a) operating the flow device to measure blood flow in at least one area, b) applying the dosage device for administering a first dosage of a vasodilator, c) operating the flow device for remeasuring blood flow, and;
d) reapplying the dosage device to administer an adjusted further dosage of a vasodilator, the further dosage being adjusted in response to said remeasured blood flow, e) repeating the operation of said system over a period of days while titrating said dosage according to still further measurements of blood flow to maintain optimal blood flow velocity.
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Abstract
A method for treatment of a disease comprising vasospasm or other symptom alleviable by smooth muscle relaxation and a vasodilator delivery system. The figure is a TCD of MCA post nitroglycerine spray obtained during continuous monitoring.
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Citations
14 Claims
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1. A method of operating a titration system for the treatment of chronic noncardiac diseases comprising vasospasm or other symptom alleviatable by smooth muscle relaxation, said system comprising a flow device and a dosage device and said method comprising in combination:
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a) operating the flow device to measure blood flow in at least one area, b) applying the dosage device for administering a first dosage of a vasodilator, c) operating the flow device for remeasuring blood flow, and;
d) reapplying the dosage device to administer an adjusted further dosage of a vasodilator, the further dosage being adjusted in response to said remeasured blood flow,e) repeating the operation of said system over a period of days while titrating said dosage according to still further measurements of blood flow to maintain optimal blood flow velocity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13)
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10. A method of treatment of intracranial vasospasms comprising intermittently applying a vasodilator and measuring transcranial doppler mean flow velocity, and titrating dosage as the vasospasms reduce in frequency and/or severity.
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14. A method for operating a titration system for diagnosing and treating a disease caused at least partially by insufficient cerebral perfusion, comprising in combination:
- operating a flow device to test for the presence of a continued diastolic flow beyond end diastolic velocity as an indication of vasospasm, applying a dosage device which administers a vasospasm-reducing dosage of a medicine selected from the empirical group of medications which have the common characteristic of causing smooth muscle relaxation and/or which reduce pulmonary capillary wedge pressure, smooth muscle relaxation and/or which reduce pulmonary capillary wedge pressure, reoperating said flow device for testing over time and adjusting said dosage device to titrate said dosage to minimize occurrence and severity of said indications of vasospasm.
Specification