Hepadnavirus receptor

• US 6,258,937 B1
• Filed: 07/27/1999
• Issued: 07/10/2001
• Est. Priority Date: 07/21/1995
• Status: Expired due to Fees

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Tong, Shuping, Li, Jisu, Wands, Jack R.
• Primary Examiner(s): Wortman, Donna C.
• Assistant Examiner(s): Brumback, Brenda G.
• Application Number:
  US09/361,707
• Time in Patent Office: 714 Days
• Field of Search: 530/350, 530/412
• US Class Current: 530/350
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/20 for DNA viruses
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: C07K 14/705 Receptors; Cell surface antigens; Cell surface determinants tumour specific antigens C07K14/4748
• CPC Class Codes: C07K 2319/00 Fusion polypeptide

Abstract

The invention features an hepadnavirus cellular receptor and a nucleic acid sequence that encodes the receptor. The receptor is a 170 kD surface glycoprotein, and is referred to as the p170 receptor.

Claims

1. A purified polypeptide encoded by the nucleic acid of SEQ ID NO:

74.

2. A purified polypeptide comprising the amino acid sequence of SEQ ID NO:

75.