Implantable substrate sensor
First Claim
1. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed comprising:
- an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein the means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC comprises vias that pass though the body of the semiconductor substrate; and
a protective coating, for enabling the sensor to be implanted in living tissue, that covers all surfaces of the semiconductor substrate except for selected portions of the sensor electrodes and selected portions of said means for making electrical connection with and providing operating power to the electronic circuitry.
1 Assignment
0 Petitions
Accused Products
Abstract
An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensors may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor'"'"'s electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.
1128 Citations
13 Claims
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1. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed comprising:
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an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein the means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC comprises vias that pass though the body of the semiconductor substrate; and
a protective coating, for enabling the sensor to be implanted in living tissue, that covers all surfaces of the semiconductor substrate except for selected portions of the sensor electrodes and selected portions of said means for making electrical connection with and providing operating power to the electronic circuitry.
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2. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed, comprising:
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an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
a protective coating that covers all areas of the surface of the semiconductor substrate except for selected portions of the sensor electrodes; and
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein the means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC comprises vias that pass through the body of the semiconductor substrate;
wherein the means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC comprises vias that pass through the body of the semiconductor substrate; wherein the vias that electrically connect the sensor electrodes with the electronic circuitry through the body of the semiconductor substrate comprise stair-stepped vias.
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3. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed, comprising:
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an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
a protective coating that covers all areas of the surface of the semiconductor substrate except for selected portions of the sensor electrodes; and
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein the means for making electrical connection with and providing operating power to the electronic circuitry comprises;
a plurality of conductive pads formed on the semiconductor substrate which are not covered by the protective coating; and
a plurality of non-straight vias that respectively electrically connect each of the plurality of pads with the electronic circuitry formed on the active surface of the semiconductor substrate.
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4. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed, comprising:
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an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
a protective coating that covers all areas of the surface of the semiconductor substrate except for selected portions of the sensor electrodes; and
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein the means for making electrical connection with and providing operating power to the electronic circuitry comprises;
a plurality of conductive pads formed on the semiconductor substrate which are not covered by the protective coating; and
a plurality of non-straight vias that respectively electrically connect each of the plurality of pads with the electronic circuitry formed on the active surface of the semiconductor substrate;
wherein each end of the substrate includes a pair of said conductive pads.
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5. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed, comprising:
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an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein said electrodes and electronic circuitry include means for operating said sensor as an electrochemical sensor; and
a protective coating, for enabling the sensor to be implanted in living tissue, that covers all surfaces of the semiconductor substrate except for selected portions of the sensor electrodes and selected portions of said means for making electrical connection with and providing operating power to the electronic circuitry.
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6. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed, comprising:
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an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein said electrodes and electronic circuitry include means for operating said sensor as an electrochemical sensor;
wherein said electrodes formed on the non-active surface of the substrate include first and second working electrodes; and
a protective coating, for enabling the sensor to be implanted in living tissue, that covers all surfaces of the semiconductor substrate except for selected portions of the sensor electrodes and selected portions of said means for making electrical connection with and providing operating power to the electronic circuitry.
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7. An implantable sensor for sensing a specified parameter or substance to which the sensor is exposed, comprising:
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an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed;
sensor electrodes formed on the non-active surface of the semiconductor substrate;
means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC;
a protective coating that covers all areas of the surface of the semiconductor substrate except for selected portions of the sensor electrodes; and
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate;
wherein said electrodes and-electronic circuitry include means for operating said sensor as an electrochemical sensor;
wherein said electrodes formed on the non-active surface of the substrate include first and second working electrodes, each of the first and second working electrodes having an exposed surface area which is not covered by the protective coating;
further including;
a first membrane covering said substrate and electrodes, a saline solution held within said first membrane, said saline solution being in contact with the exposed surface areas of said electrodes, a second membrane covering the first membrane, said second membrane having a window pocket formed therein above the exposed surface area of the first working electrode, and a prescribed enzyme placed within the window pocket of the second membrane;
whereby said implantable sensor comprises an enzyme electrode sensor.
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8. An implantable sensor assembly comprising:
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a first substrate sensor having an electrode surface and a circuit surface;
a second substrate sensor also having an electrode surface and a circuit surface, the circuit surface of the second substrate sensor being placed against the circuit surface of the first substrate sensor, whereby the electrode surfaces of both the first and second substrate sensors face out from the sensor assembly;
each of the first and second substrate sensors comprising;
an integrated circuit (IC), said IC comprising a semiconductor substrate having an active surface on which electronic circuitry is formed and a non-active surface where electronic circuitry is not formed, the active surface of the substrate comprising the circuit surface of the sensor, sensor electrodes formed on the non-active surface of the semiconductor substrate, the non-active surface comprising the electrode surface of the sensor, means for electrically connecting the sensor electrodes with the electronic circuitry formed on the active surface of the IC, a protective coating that covers all areas of the surface of the semiconductor substrate except for selected portions of the sensor electrodes; and
means for making electrical connection with and providing operating power to the electronic circuitry formed on the semiconductor substrate from a location outside of the implantable sensor.
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9. A substrate sensor for immersion or implantation in a saline solution comprising:
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a semiconductor substrate having front, back, and side surfaces;
at least one working electrode formed on the front side of the semiconductor substrate;
electronic circuitry formed on the back side of the semiconductor substrate;
a via that passes through the semiconductor substrate and electrically connects the at least one working electrode with the electronic circuitry;
means for coupling operating signals with the electronic circuitry; and
a protective coating, for enabling the sensor to be implanted in living tissue, that covers all surfaces of the semiconductor substrate with a biocompatible protective layer except for selected portions of the at least one working electrode and selected portions of said means for coupling operating signals to the electronic circuitry. - View Dependent Claims (10)
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11. A substrate sensor for immersion or implantation in a saline solution comprising:
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a semiconductor substrate having front and back surfaces;
at least one working electrode formed on the front side of the semiconductor substrate;
electronic circuitry formed on the back side of the semiconductor substrate;
a via that passes through the semiconductor substrate and electrically connects the at least one working electrode with the electronic circuitry;
a coating that covers the semiconductor substrate with a biocompatible protective layer except for an exposed area of the at least one working electrode;
means for coupling operating signals with the electronic circuitry;
wherein electronic circuitry comprises a CMOS integrated circuit, and wherein the semiconductor substrate comprises a portion of a semiconductor wafer on which the CMOS integrated circuit is formed; and
whereinsaid protective coating comprises at least one layer of a biocompatible encapsulation material selected from the group comprising alumina, zirconia, or alloys of alumina and/or zirconia. - View Dependent Claims (12, 13)
a plurality of conductive pads formed on the semiconductor substrate which are not covered by the protective coating; and
a plurality of non-straight vias that respectively electrically connect each of the plurality of pads with the electronic circuitry formed on the back surface of the semiconductor substrate.
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13. The substrate sensor of claim 12 wherein the electronic circuitry formed on the back surface of the semiconductor substrate includes at least one built-in capacitor, said at least one built-in capacitor comprising a first conductive layer formed on the substrate, a dielectric layer deposited over the first conductive layer, a second conductive layer deposited over the dielectric layer, and conductive means for making electrical connection with the first and second conductive layers.
Specification