Bioresonance feedback method and apparatus

• US 6,261,236 B1
• Filed: 10/26/1998
• Issued: 07/17/2001
• Est. Priority Date: 10/26/1998
• Status: Expired due to Fees

• Current Assignee: Valentin Grimblatov
• Original Assignee: Valentin Grimblatov
• Inventors: Grimblatov, Valentin
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): ASTORINO, MICHAEL C
• Application Number:
  US09/178,788
• Time in Patent Office: 995 Days
• Field of Search: 600/300, 600/481-486, 600/500-508, 600/476, 600/479, 128/900
• US Class Current: 600/500
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 5/1064 for adjusting radiation treatment in response to monitoring

Abstract

A biofeedback method and apparatus for applying a physical action to a subject for treatment purposes and for other applications is disclosed. The method and apparatus disclosed include the steps of coordinating the physical action to systolic upstroke and diastolic drain cycles of subject'"'"'s peripheral blood flow. Coordination to the cycles of blood flow synchronizes the treatment action with homoeostatic rhythms of the body, which along with automatic dose individualization substantially enhance efficiency and predictability of the treatment effect. The method and apparatus are also used for diagnostic purposes.

Claims

1. A bioresonance feedback method, comprising the steps of applying a physical factor to a subject for medical purposes;

and automatically coordinating the applying of the physical factor to the subject with cycles of arterial blood pulse flow of the subject.

2. A biofeedback method as defined in claim 1, wherein said coordinating includes sensing arterial blood pulse waves of a subject'"'"'s body, selecting in each pulse wave a systolic influx and diastolic drain blood cycles, generating feedback signals in a first channel synchronously to the systolic influx cycles and in a second channel synchronously to diastolic drain cycles, and synchronizing the physical action to said cycles by controlling the physical action by feedback signals of the first and second channels.

3. A biofeedback method as defined in claim 2, wherein said sensing includes sensing the pulse waves by photoplethysmography.

4. An biofeedback apparatus comprising means for application of a physical action to a subject for medical purposes;

and means for automatically coordinating the applying the physical action to the subject, in accordance with cycles of arterial blood pulse flow of the subject.

5. A biofeedback method for applying a physical action to a subject for medical purposes comprising the steps of coordinating applying of a physical factor to a subject with cycles of arterial blood pulse flow of the subject, said coordinating including sensing arterial blood pulse waves of a subject'"'"'s body, selecting in each pulse wave a systolic influx and diastolic drain blood cycles, generating feedback signals in a first channel synchronously to the systolic influx cycles and in a second channel synchronously to a diastolic drain cycles, and synchronizing the physical action to said cycles by controlling the physical action by feedback signals of the first and second channels, said sensing including photo-electrically detecting the pulse waves from a nearest to an effected area location where a pulse wave can be detected.

6. A biofeedback method for applying a physical action to a subject for medical purposes comprising the steps of coordinating applying of a physical action to a subject with cycles of arterial blood pulse flow of the subject, said coording including sensing arterial blood pulse waves of a subject'"'"'s body, selecting in each pulse wave a systolic influx and diastolic drain blood cycles, generating feedback signals in a first channel synchronously to the systolic influx cycles and in a second channel synchronously to a diastolic drain cycles, and synchronizing the physical action to said cycles by controlling the physical action by feedback signals of the first and second channels, said selecting including locating in the pulse wave points of discrimination between said systolic upstroke and diastolic descent intervals.

7. A biofeedback method as defined in claim 6, wherein said locating the points of discrimination includes locating systolic peak points and points of maximum systolic upstroke rate.

8. A biofeedback method as defined in claim 6, wherein locating the points of discrimination includes locating a points of discrimination of systolic onset and systolic peak points.

9. A biofeedback method as defined in claim 6, wherein said locating the points of discrimination includes dividing an average time interval between pulse waves in a predetermined proportion.

10. A biofeedback method as defined in claim 9, wherein said dividing includes dividing a time interval between points of maximum systolic upstroke rate.

11. A biofeedback method as defined in claim 9, wherein said dividing includes dividing an interval between said systolic peak points.

12. A biofeedback method as defined in claim 9, wherein said dividing includes dividing in the predetermined proportion within a range from 1/7 to 1/5.

13. A biofeedback method as defined in claim 7, wherein said locating the points of maximum systolic upstream rate and systolic peak points includes differentiating twice the pulse wave with respect to time to produce first and second differentiated waves, comparing amplitudes of the pulse wave and the first differentiating wave with predetermined reference signals for discriminating the systolic peaks on the pulse wave and positive peaks in the first differentiated wave, detecting zero-crossing of the first and second differentiated waves, and locating the systolic peak points as points of the first differentiated wave zero-crossing within discriminated systolic peak and locating the points of maximum systolic upstroke rate as points of the second differentiated wave zero-crossing with discriminated positive peak of the first differentiated wave.

14. A biofeedback method as defined in claim 6, wherein said generating includes providing square pulse signals in the first channel synchronously and with a pulse width being equal to occurrence and duration of the systolic upstroke intervals and in the second channels synchronously and with a pulse width being equal to occurrence and duration of the diastolic decent intervals.

15. An apparatus for application of a physical action to a subject for medical purposes, comprising means for applying the physical action to a subject in accordance with cycles of arterial blood pulse flow of the subject, said applying means including a sensor for sensing blood pulses from a body of the subject comprising a probe with a source and a detector of electromagnetic radiation mounted with possibility for gripping a part of the body at a place where a portion of an electromangetic radiation attenuated by blood content tissue is detachable, sensing means for producing an output signal corresponding to an alternative component of the attenuated electromagnetic radiation, a conditioning electronic circuit to which said probe is electrically connected, input conditioning means connected to said detector for removing a direct current component from a pulse wave signal and for smoothing an alternative component wave form, a processing electronic circuit to which said conditioning circuit electrically connected, input processing means connected to said signal conditioning circuit for locating on the pulse wave points of discrimination between systolic upstroke and diastolic descent intervals, locating means identifying time moments corresponding to the points on the pulse wave, a feedback controlling electronic circuit to which said processing circuit is electrically connected, input controlling means connected to said processing circuit for providing to first output channel square electrical pulses synchronously and with duration equal to occurrence and duration of systolic upstroke intervals and providing to a second output channel square electrical pulses synchronously and with duration equal to occurrence and duration of diastolic descent intervals, and a source of electrical energy to which said electronic circuits are electronically connected.

16. An apparatus as defined in claim 15, wherein said source and said detector of electromagnetic radiation are light emitting diode and photodiode.

17. An apparatus as defined in claim 15, wherein said conditioning circuit includes a first differential amplifier with a negative terminal to which said photodiode is electrically connected, a second differential amplifier with a negative terminal to which said photodiode is electrically connected, an inverter-filter to which said second differential amplifier is electrically connected and whose output is electrically connected through a resistor to said negative terminal of said first differential amplifier, and a filter to which an output of said first differential amplifier is electrically connected for eliminating noise and ambient-like signal.

18. An apparatus as defined in claim 15, wherein said processing circuit includes a first peak detector to which said sensing circuit is electrically connected for detecting systolic upstroke peak points on the pulse wave, and a second peak detector to which said sensing circuit is also electrically connected for detecting points of maximal systolic upstroke rate on the pulse wave.

19. An apparatus as defined in claim 18, wherein said feedback controlling circuit includes a trigger to which said first peak detector and said second peak detector are electrically connected, input triggering means for providing to said first output channel square electric pulses sychronously and with duration equal to occurrence and duration of the systolic upstroke intervals and providing to said second output channel square electric pulses synchronously and with duration equal to occurrence and duration of the diastolic decent intervals, and first and second power amplifier to which correspondingly are connected said first and second channels for power amplifying of the square electric pulses.

20. An apparatus as defined in claim 15, wherein said processing circuit includes a first comparator to which said conditioning circuit and first source of reference signal are electrically connected, input comparing means for providing to the output square pulses corresponding to time intervals when amplitudes of the pulse waves of the alternative component are above a predetermined value of a first reference signal, a first differentiating circuit to which said conditioning circuit is electrically connected, input differentiating means for providing to the output a first differentiated wave, a first zero-cross detector to which said first differentiating circuit is electrically connected for detecting zero-crossing points of said first differentiated wave, a first logic gate to which said first zero-cross detector and said first comparator are electrically connected for selecting peak systolic points, a second comparator to which said first differentiating circuit and a second source of reference signal are electrically connected, input comparing means for providing to the output square pulses corresponding to time intervals which amplitudes of positive half wave of said first differentiated wave are above a predetermined value of the second reference signal, a second differentiating signal to which said first differenting circuit is electrically connected, input differentiating means for providing to the output a second differentiated wave, a second zero-cross detector to which said second differentiating circuit is electrically connected for detecting zero-crossing points of said second differentiated wave, and a second logic gate to which said second zero-cross detector and said second comparator are electrically connected for selecting points of maximal systolic upstroke rate.

21. An apparatus as defined in claim 20, wherein said first and second logic gates are an AND gate.

22. An apparatus as defined in claim 20, wherein said filter is a low pass filter.

23. An apparatus as defined in claim 15, wherein said processing circuit includes only a systolic peak detector which is electrically connected to said sensor for producing a train of square pulse signals synchronously to systolic peak points.

24. An apparatus as defined in claim 23, wherein said controlling circuit includes a trigger pulse differentiator to which said peak detector is electrically connected for decreasing a pulse width, a timer to which said trigger pulse differentiator is electrically connected for providing to the output square pulse signals with pulse width which is equal to a predetermined portion of a time between pulse waves, and an invertor to which said timer is electrically connected for establishing a second output for pulse signals having pulse width equal to a difference between time between pulse waves and a pulse width of signals in said first channel.

25. An apparatus as defined in claim 24, wherein a predetermined quotient is within a range from 1/7 to 1/5.

26. An apparatus as defined in claim 24, wherein said points of discrimination between the pulse waves are points of maximal systolic upstroke rate.

27. An apparatus as defined in claim 24, wherein points of discrimination between the pulse waves are systolic peak points.

28. An apparatus as defined in claim 15, wherein said sensor and said processing circuit are a pulse oxymeter.