Multi-layered polymer based thin film structure for medical grade products

• US 6,261,655 B1
• Filed: 06/17/1999
• Issued: 07/17/2001
• Est. Priority Date: 11/16/1993
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Anderson, William, Nebgen, Gregg, Buan, Angeles Lillian, Ling, Michael T. K., Rosenbaum, Larry A., Laurin, Dean, Woo, Lecon, Ding, Yuan Pang Samuel, Hayward, Denise S., Hoppesch, Joseph P., Westphal, Stanley
• Primary Examiner(s): Chen, Vivian
• Application Number:
  US09/334,957
• Time in Patent Office: 761 Days
• Field of Search: 428/36.6, 428/36.7, 428/345, 428/355, 428/475.8, 428/476.1, 428/476.3, 428/476.9, 428/515, 428/520, 428/516, 428/523, 428/521, 428/522, 428/355.EN, 428/355.BL, 428/355.AC, 428/355.N, 428/423.1, 428/424.2, 428/473.5, 428/483, 428/501, 428/505, 428/517, 428/519, 525/88, 525/66, 525/92.R, 525/92.B, 525/93, 525/95, 525/96, 525/178, 525/185, 525/191, 525/222, 525/240, 525/241, 525/92.C, 525/92.F, 525/94, 525/98
• US Class Current: 428/36.7
• CPC Class Codes: B29C 48/08 flexible, e.g. films
• CPC Class Codes: B29C 48/185 comprising six or more components, i.e. each component being counted once for each time it is present, e.g. in a layer
• CPC Class Codes: B32B 2323/046 LDPE, i.e. low density polyethylene
• CPC Class Codes: B32B 2323/10 Polypropylene
• CPC Class Codes: B32B 2439/80 Medical packaging
• CPC Class Codes: B32B 27/08 of synthetic resin
• CPC Class Codes: B32B 27/18 characterised by the use of special additives
• CPC Class Codes: B32B 27/32 comprising polyolefins comprising vinyl (co)polymers or acrylic (co)polymers B32B27/30
• CPC Class Codes: C08L 23/08 Copolymers of ethene C08L23/16 takes precedence
• CPC Class Codes: C08L 23/0815 Copolymers of ethene with aliphatic 1-olefins
• CPC Class Codes: C08L 23/0853 Vinylacetate
• CPC Class Codes: C08L 23/0869 Acids or derivatives thereof
• CPC Class Codes: C08L 23/10 Homopolymers or copolymers of propene
• CPC Class Codes: C08L 25/04 Homopolymers or copolymers of styrene
• CPC Class Codes: C08L 2666/04 Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
• CPC Class Codes: C08L 53/00 Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 53/02 of vinyl-aromatic monomers and conjugated dienes
• CPC Class Codes: Y10T 428/1379 Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
• CPC Class Codes: Y10T 428/1383 Vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit is sandwiched between layers [continuous layer]
• CPC Class Codes: Y10T 428/2809 including irradiated or wave energy treated component
• CPC Class Codes: Y10T 428/2848 : Three or more layers
• CPC Class Codes: Y10T 428/2878 : including addition polymer from unsaturated monomer
• CPC Class Codes: Y10T 428/2883 : including addition polymer of diene monomer [e.g., SBR, SIS, etc.]
• CPC Class Codes: Y10T 428/2891 : including addition polymer from alpha-beta unsaturated carboxylic acid [e.g., acrylic acid, methacrylic acid, etc.] Or derivative thereof
• CPC Class Codes: Y10T 428/2896 : including nitrogen containing condensation polymer [e.g., polyurethane, polyisocyanate, etc.]
• CPC Class Codes: Y10T 428/31551 : Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31573 : Next to addition polymer of ethylenically unsaturated monomer
• CPC Class Codes: Y10T 428/31721 : Of polyimide
• CPC Class Codes: Y10T 428/31743 : Next to addition polymer from unsaturated monomer[s]
• CPC Class Codes: Y10T 428/31746 : Polymer of monoethylenically unsaturated hydrocarbon
• CPC Class Codes: Y10T 428/3175 : Next to addition polymer from unsaturated monomer[s]
• CPC Class Codes: Y10T 428/31757 : Polymer of monoethylenically unsaturated hydrocarbon
• CPC Class Codes: Y10T 428/31797 : Next to addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31859 : Next to an aldehyde or ketone condensation product
• CPC Class Codes: Y10T 428/31873 : Urea or modified urea-aldehyde
• CPC Class Codes: Y10T 428/31909 : Next to second addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31913 : Monoolefin polymer
• CPC Class Codes: Y10T 428/31917 : Next to polyene polymer
• CPC Class Codes: Y10T 428/31924 : Including polyene monomers
• CPC Class Codes: Y10T 428/31928 : Ester, halide or nitrile of addition polymer
• CPC Class Codes: Y10T 428/31931 : Polyene monomer-containing
• CPC Class Codes: Y10T 428/31935 : Ester, halide or nitrile of addition polymer
• CPC Class Codes: Y10T 428/31938 : Polymer of monoethylenically unsaturated hydrocarbon

Abstract

A multiple layer structure comprising a skin layer composed of a polypropylene copolymer with styrene ethylene-butene styrene block copolymer within a range of 0-20% by weight skin layer, and, a radio frequency (“RF”) susceptible layer adhered to the skin layer. The RF layer has a first component of a propylene based polymer, a second component of a nonpropylene polyolefin, a third component of a radio frequency susceptible polymer, and a fourth component of a polymeric compatibilizing agent wherein the radio frequency susceptible polymer is selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas.

Claims

1. A multiple layer thermoplastic structure:

(1) a skin layer selected from the group consisting of polypropylene and polypropylene copolymers;

(2) a radio frequency susceptible layer adhered to the skin layer, the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C., the radio frequency susceptible layer having;

(a) a first polyolefin selected from the group consisting of polypropylene and polypropylene copolymers,

(b) a second polyolefin selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers;

(c) a radio frequency susceptible polymer selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas, and

(d) a compatibilizing agent of a styrene and hydrocarbon block copolymer;

wherein the structure has physical properties within the range

a<

40,000 psi;

b>

=70%;

c<

30%;

d>

1.0;

e<

0.1%;

f<

0.1%;

g>

=0.05

h<

=60%;

i=0;

wherein;

a is the mechanical modulus of the composition measured according to ASTM D-882;

b is the percent recovery in length of the composition after an initial 20% deformation;

c is the optical haze of the composition processed into a film 9 mils in thickness measured in accordance to ASTM D-1003;

d is the loss tangent of the composition at 1 Hz measured at melt processing temperatures;

e is the elemental halogen content by weight of the composition;

f is the low molecular weight water soluble fraction of the composition;

g is the dielectric loss between 1 and 60 MHz and over temperatures of 25 to 250°

C. of the composition;

h is the sample creep measured at 121°

C. for a sample strip of the composition under 27 psi loading; and

,

i the composition exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length;

and wherein the multiple layer structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, and wherein the multiple layer structure is capable of being thermoplastically recycled.

2. A multiple layer thermoplastic structure suitable for manufacturing medical products comprising:

(1) a skin layer selected from the group consisting of polypropylene and polypropylene copolymers; and

,

(2) a radio frequency susceptible layer adhered to the skin layer, the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C., the radio frequency susceptible layer comprising;

(a) a first polyolefin selected from the group consisting of polypropylene and polypropylene copolymers;

(b) a second polyolefin selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers;

(c) a radio frequency susceptible polymer selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas; and

(d) a first compatibilizing agent of a styrene and hydrocarbon block copolymer;

wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, the structure has a sample creep measured at 121°

C. for a sample strip of the structure under 27 psi loading of less than or equal to 60%, and wherein the multiple layer structure is capable of being thermoplastically recycled.

3. The structure of claim 2 wherein the styrene and hydrocarbon block copolymer is selected from a group consisting of a first styrene-ethylene-butene-styrene block copolymer, and a maleic anhydride functionalized block copolymer.

4. The structure of claim 2 further comprising:

a first core layer attached to the radio frequency susceptible layer and having;

(a) a third polyolefin selected from the group consisting of polypropylene and polypropylene copolymers,

(b) a fourth polyolefin selected from the group consisting of ultra low density polyethylene, and polybutene-1 copolymers; and

(c) a second compatibilizing agent of a styrene and hydrocarbon block copolymer.

5. The structure of claim 4 wherein the first core layer is positioned between the radio frequency susceptible layer and the skin layer.

6. The structure of claim 4 further comprising

a beneficial agent contact layer attached to the radio frequency susceptible layer on a side opposite the skin layer, the contact layer comprises:

(a) a polypropylene,

(b) an ultra low density polyethylene, and,

(c) a third styrene and hydrocarbon block copolymer.

7. The structure of claim 6 further comprising:

a first scrap layer comprising a first scrap material;

a first barrier layer; and

wherein the first core layer, first scrap layer and first barrier layer are attached together in any order and are together attached to the susceptible layer on a side opposite the skin layer.

8. The structure of claim 7 wherein the first core layer further includes a second scrap material.

9. The structure of claim 7 further comprising a second scrap material interposed between the first core layer and the radio frequency susceptible layer.

10. A multiple layer thermoplastic structure suitable for manufacturing medical products, the structure comprising:

(1) a skin layer from the group consisting of polypropylene and polypropylene copolymers; and

,

(2) a radio frequency susceptible layer adhered to the skin layer, the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C. and comprising;

(a) a first polyolefin in an amount in a range of 30-60% by weight of the radio frequency susceptible layer and selected from the group consisting of polypropylene and polypropylene copolymers,

(b) a second polyolefin in an amount within the range of 25-50% by weight of the radio frequency susceptible layer selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers;

(c) a radio frequency susceptible polymer in an amount within the range of 3-40% by weight of the radio frequency susceptible layer selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas, and

(d) a compatibilizing agent of a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the radio frequency susceptible layer, and

wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, the structure has a sample creep measured at 121°

C. for a sample strip of the structure under 27 psi loading of less than or equal to 60%, and wherein the multiple layer structure is capable of being thermoplastically recycled.

11. The structure of claim 10 wherein the radio frequency susceptible polymer is a polyurethane.

12. The structure of claim 10 wherein the radio frequency susceptible polymer is an ethylene methacrylic acid copolymer.

13. The structure of claim 10 wherein the compatibilizing agent is a styrene-ethylene-butene-styrene block copolymer.

14. The structure of claim 10 wherein the compatibilizing agent comprises a styrene-ethylene-butene-styrene block copolymer that is maleic anhydride functionalized.

15. The structure of claim 10 wherein the radio frequency susceptible layer comprises by weight of the susceptible layer:

from about 35% to about 45% polypropylene;

from about 35% to about 45% of the second polyolefin;

from about 7% to about 13% of the radio frequency susceptible polymer; and

,

from about 7% to about 13% of a styrene and hydrocarbon block copolymer.

16. A multiple layer thermoplastic structure suitable for fabricating medical products comprising:

a skin layer selected from the group consisting of a polypropylene and polypropylene copolymers;

a core layer having a first side adhered to the skin layer and a second side; and

,

a radio frequency susceptible layer having a first side adhered to the second side of the core layer comprising;

a first polyolefin selected from the group consisting of a polypropylene and polypropylene copolymers in an amount from 30-60% of the weight of the radio frequency susceptible layer,

a second polyolefin in an amount from 25-50% of the weight of the radio frequency susceptible layer and selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, butene ethylene copolymers, ethylene copolymers with vinyl acetate having from 18-50% by weight vinyl acetate comonomer, ethylene methyl acrylate copolymers with methyl acrylate contents being from 20-40% by weight, ethylene n-butyl acrylate copolymers with n-butyl acrylate content from 20-40% by weight, and ethylene acrylic acid copolymers with the acrylic acid content of greater than approximately 15% by weight,

a radio frequency susceptible polymer in an amount within the range of 3-40% by weight of the radio frequency susceptible layer and selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas, and

a first compatibilizing agent in an amount within the range of 5-40% by weight of the radio frequency susceptible layer and of a styrene and hydrocarbon block copolymer,

and wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches (50 cm) per minute to about 100% elongation (twice the original length) and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, the structure has a sample creep measured at 121°

C. for a sample strip of the structure under 27 psi loading of less than or equal to 60%, and wherein the multiple layer structure is capable of being thermoplastically recycled.

17. The structure of claim 16 wherein the core layer has a dielectric loss equal to or less than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C.

18. The structure of claim 16 wherein the second polyolefin is selected from the group consisting of ultra low density polyethylene and polybutene-1,

wherein the first compatibilizing agent is selected from the group consisting of a styrene-ethylene-butene-styrene block copolymer, and a styrene-ethylene-butene-styrene block copolymer functionalized by a functional group selected from the group consisting of a maleic anhydride, epoxy and carboxylate;

and wherein the core layer comprises;

(1) a third polyolefin selected from the group consisting of polypropylene and polypropylene copolymers;

(2) a fourth polyolefin selected from the group consisting of an ultra low density polyethylene and a polybutene copolymer; and

(3) a second compatibilizing agent of a styrene and hydrocarbon block copolymer.

19. The structure of claim 16 wherein the core layer further includes a scrap material.

20. The structure of claim 16 wherein the radio frequency susceptible polymer is a polyurethane.

21. The structure of claim 16 wherein the radio frequency susceptible polymer is a ethylene methacrylic acid copolymer.

22. A multiple layer thermoplastic structure of stacked layers suitable for manufacturing medical products comprising:

(1) a skin layer having a first side and being selected from a group consisting of a polypropylene and polypropylene copolymers;

(2) a radio frequency susceptible layer having second and third sides, the radio frequency susceptible layer comprising

(a) a polypropylene in an amount from 30-60% of the weight of the radio frequency susceptible layer,

(b) a first polyolefin in an amount from 25-50% of the weight of the radio frequency susceptible layer and selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers,

(c) a radio frequency susceptible polymer in an amount from 3-40% by weight of the radio frequency susceptible layer and selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas,

(d) a first compatibilizing agent of a styrene and hydrocarbon block copolymer in an amount from 5-40% by weight of the radio frequency susceptible layer; and

(e) wherein the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C.;

(3) a first core layer having fourth and fifth sides;

(4) scrap layer having sixth and seventh sides; and

wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, the structure has a sample creep measured at 121°

C. for a sample strip of the structure under 27 psi loading of less than or equal to 60%, and wherein the multiple layer structure is capable of being thermoplastically recycled.

23. The structure of claim 22 wherein the first side is adjacent to the fourth side, the sixth side is adjacent to the fifth side, and the second side is adjacent to the seventh side.

24. The structure of claim 22 wherein the first side is adjacent to the sixth side, the fourth side is adjacent to the seventh side, and the second side is adjacent to the fifth side.

25. The structure of claim 22 further including a second core layer interposed between the first core layer and the susceptible layer.

26. The structure of claim 22 wherein the polyolefin is selected from the group consisting of an ultra low density polyethylene and polybutene-1, the radio frequency susceptible polymer is selected from the group of polyurethanes and ethylene methacrylic acid copolmers, the first compatibilizing agent is styrene-ethylene-butene-styrene block copolymer, and the first core layer comprises:

a polyolefin selected from the group consisting of a polypropylene and a polypropylene copolymer;

a polyolefin selected from the group consisting of an ultra low density polyethylene and a polybutene copolymer; and

,

a second compatibilizing agent of a styrene and hydrocarbon block copolymer.

27. A multiple layer thermoplastic structure suitable for manufacturing medical products comprising:

(1) a skin layer having a first side and being selected from a group consisting of a polypropylene and polypropylene copolymers;

(2) a radio frequency susceptible layer having sixth and seventh sides and comprising;

(a) a propylene-containing polymer in an amount in a range of 30-60% of the weight of the radio frequency susceptible layer,

(b) a first polyolefin in an amount within the range of 25-50% of the weight of the radio frequency susceptible layer and selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers;

(c) a radio frequency susceptible polymer in an amount within the range of 3-40% by weight of the radio frequency susceptible layer and selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas;

(d) a compatibilizing agent of a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the radio frequency susceptible layer; and

(e) wherein the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C.;

(3) a first core layer having fourth and fifth sides and disposed between the skin layer and the radio frequency susceptible layer;

(4) a barrier layer having second and third sides adjacent to the core layer, and wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, the structure has a sample creep measured at 121°

C. for a sample strip of the structure under 27 psi loading of less than or equal to 60%, and wherein the multiple layer structure is capable of being thermoplastically recycled.

28. The structure of claim 27 wherein the first side is adjacent to the second side, the fourth side is adjacent to the third side, and the sixth side is adjacent to the fifth side.

29. The structure of claim 27 wherein the first side is adjacent to the fourth side, the second side is adjacent to the fifth side, and the sixth side is adjacent to the third side.

30. The structure of claim 29 further including a second core layer interposed between the first core layer and the radio frequency susceptible layer.

31. The structure of claim 27 wherein the first polyolefin is an ultra low density polyethylene or a polybutene-1, the radio frequency susceptible polymer is a polyurethane or a ethylene methyl acrylic acid copolymer, the compatibilizing agent is a styrene-ethylene-butene-styrene block copolymer, and wherein the barrier layer comprises an ethylene vinyl alcohol or a polyamide.

32. The structure of claim 27 further including a first tie layer adjacent to the second side of the barrier layer and a second tie layer adjacent to the third side of the barrier layer.

33. The structure of claim 32 wherein the first and second tie layers comprise modified ethylene and propylene copolymers.

34. A multiple layer thermoplastic structure suitable for manufacturing medical products comprising:

(1) a skin layer comprising a polypropylene copolymer and a styrene and hydrocarbon block copolymer within a range of 0-20% by weight of the skin layer;

(2) a core layer adhered to the skin layer; and

,

(3) a radio frequency susceptible layer adhered to the core layer comprising;

(a) a polypropylene having a melting point temperature greater than 130°

C. and a modulus less than 20,000 psi in an amount in a range of 30-60% of the weight of the radio frequency susceptible layer,

(b) a radio frequency susceptible polymer in an amount within the range of 3-40% by weight of the radio frequency susceptible layer and is selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas;

(c) a first compatibilizing agent of a styrene and hydrocarbon block copolymer in an amount within the range of 5-20% by weight of the radio frequency susceptible layer, and

(d) wherein the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C.;

wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, and wherein the multiple layer structure is capable of being thermoplastically recycled.

35. The structure of claim 34 wherein the core layer comprises:

(a) a polyolefin selected from the group consisting of polypropylene and polypropylene copolymers;

(b) a second component selected from the group consisting of an ultra low density polyethylene and a polybutene-1 copolymer; and

(c) a second compatibilizing agent of a styrene and hydrocarbon block copolymer.

36. A multiple layer thermoplastic structure suitable for manufacturing medical products comprising:

(1) a skin layer selected from the group consisting of polypropylene and polypropylene copolymers; and

,

(2) a radio frequency susceptible layer adhered to the skin layer, the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C., the radio frequency susceptible layer comprising;

(a) a first polyolefin selected from the group consisting of polypropylene and polypropylene copolymers;

(b) a second polyolefin selected from the group consisting of ultra-low density polyethylene, polybutene, and butene ethylene copolymers;

(c) a radio frequency susceptible polymer selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas; and

(d) a first compatibilizing agent of a styrene and hydrocarbon block copolymer;

wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, the structure has a sample creep measured at 121°

C. for a sample strip of the structure under 27 psi loading of less than or equal to 60%, and wherein the multiple layer structure is capable of being thermoplastically recycled.

37. A multiple layer thermoplastic structure suitable for manufacturing medical products comprising:

(1) a skin layer comprising a polypropylene copolymer and a styrene and hydrocarbon block copolymer within a range of 0-20% by weight of the skin layer;

(2) a radio frequency susceptible layer adhered to the skin layer comprising;

(a) a polypropylene having a melting point temperature greater than 130°

C. and a modulus less than 20,000 psi in an amount in a range of 30-60% of the weight of the radio frequency susceptible layer,

(b) a radio frequency susceptible polymer in an amount within the range of 3-40% by weight of the radio frequency susceptible layer and selected from the group consisting of ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, and polyureas;

(c) a first compatibilizing agent of a styrene and hydrocarbon block copolymer in an amount within the range of 5-20% by weight of the radio frequency susceptible layer, and

(d) wherein the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250°

C.; and

(3) wherein the multiple layer structure has a mechanical modulus of less than 40,000 psi when measured according to ASTM D-882, the optical haze of the structure processed into a film 9 mils in thickness measured in accordance to ASTM D-1003 is less than 30%, the structure exhibits no strain whitening after being strained at moderate speeds of about 20 inches per minute to about twice the original length and the structure is capable of storing or collecting beneficial agents or transferring such agents to a patient, the structure has a sample creep measured at 121°

C. for a sample strip of the structure under 27 psi loading of less than or equal to 60%, and wherein the multiple layer structure is capable of being thermoplastically recycled.