Methods for purifying viruses
First Claim
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1. A method of purifying adenovirus from a virus preparation, comprising the successive steps of:
- a) subjecting the virus preparation to anion-exchange chromatography, wherein the adenovirus is eluted from an anion-exchange chromatographic medium; and
b) subjecting the eluate of step a) which contains the adenovirus to size exclusion chromatography, wherein the adenovirus is eluted from a size exclusion chromatographic medium.
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Abstract
The invention provides methods for purifying a virus from impurities in an aqueous medium.
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14 Claims
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1. A method of purifying adenovirus from a virus preparation, comprising the successive steps of:
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a) subjecting the virus preparation to anion-exchange chromatography, wherein the adenovirus is eluted from an anion-exchange chromatographic medium; and
b) subjecting the eluate of step a) which contains the adenovirus to size exclusion chromatography, wherein the adenovirus is eluted from a size exclusion chromatographic medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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