Miniature magnetic resonance catheter coils and related methods

• US 6,263,229 B1
• Filed: 11/13/1998
• Issued: 07/17/2001
• Est. Priority Date: 11/13/1998
• Status: Expired due to Term

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Lestio, Jeffrey C., Carkhuff, Bliss G., Atalar, Ergin, Bottomley, Paul A., Charles, Harry K. Jr.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US09/191,563
• Time in Patent Office: 977 Days
• Field of Search: 600/410, 600/422, 600/423, 324/307, 324/309, 324/318, 324/322, 296/021
• US Class Current: 600/423
• CPC Class Codes: G01R 33/34007 Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system
• CPC Class Codes: G01R 33/34084 implantable coils or coils being geometrically adaptable to the sample, e.g. flexible coils or coils comprising mutually movable parts
• CPC Class Codes: G01R 33/341 comprising surface coils
• CPC Class Codes: G01R 33/3657 Decoupling of multiple RF coils wherein the multiple RF coils do not have the same function in MR, e.g. decoupling of a transmission coil from a receive coil
• CPC Class Codes: G01R 33/3678 involving quadrature drive or detection, e.g. a circularly polarized RF magnetic field

Abstract

The present invention provides several embodiments of methods of making magnetic resonance catheter coils which include employing a flexible electrically insulative base member, depositing an electrically conductive material on the base member in a predetermined pattern to create at least one pair of generally parallel electrically conductive coil elements which are electrically connected to each other. A catheter is provided over the coil assembly. In one embodiment, a second pair of generally parallel electrically conductive coil elements are provided in order to create a quadrature coil. In this latter embodiment, the electrically insulative base member may have the first pair of coil elements created on one surface thereof and a second pair on the other with the base member subsequently being deformed to create a tubular coil having one pair of coil elements on the outside and the other pair on the inside. In some embodiments, tuning and matching circuits and decoupling circuits may be provided. The (a) coils, (b) coil assemblies, as well as (c) catheter coils containing coil assemblies produced by these methods are also disclosed. The coils may be miniaturized so as to facilitate ready insertion within a suitable sheath, such as a probe or catheter, into a patient, including into body openings, or into blood vessels or into interior regions of the body.

Claims

1. A method of making a magnetic resonance catheter coil comprising:

providing a flexible circuit board having a first outer surface;

forming electrically conductive material on said first outer surface of said circuit board into a first coil element having a length and a width;

forming electrically conductive material on said first outer surface of said circuit board into a second coil element, said second coil element having a length and a width and positioned substantially parallel to, and a distance from, said first coil element;

forming electrically conductive material on said first outer surface of said circuit board to form a connector portion joining said first coil element and said second coil element, the combination of said first coil element and said second coil element and said connector portion constituting a first magnetic resonance coil; and

covering said magnetic resonance coil and said circuit board to provide said magnetic resonance catheter coil.

2. The method of claim 1 including

severing a portion of said circuit board upon which said first magnetic resonance coil was formed to create a first unitary coil assembly.

3. The method of claim 2 including

forming a second magnetic resonance coil on a circuit board, said second magnetic resonance coil comprising a third coil element and a fourth coil element substantially parallel to said third coil element and a second connector portion joining said third coil element to said fourth coil element;

severing a portion of said circuit board upon which said second magnetic resonance coil was formed to create a second unitary coil assembly;

arranging said first unitary coil assembly and said second unitary coil assembly such that the plane including said first coil element and said second coil element is perpendicular to the plane including said third coil element and said fourth coil element.

4. The method of claim 1 including

forming a plurality of said magnetic resonance coils on said circuit board, and severing individual coils therefrom.

5. The method of claim 1 including

creating said magnetic resonance coil with an average width of about 0.2 to 10 mm.

6. The method of claim 5 including

creating said magnetic resonance coil with a thickness of about 0.1 to 10 mm.

7. The method of claim 6 including

creating said magnetic resonance coil with a length of about 1 to 30 cm.

8. The method of claim 1 including

forming a second magnetic resonance coil on said circuit board, said second magnetic resonance coil comprising a third coil element and a fourth coil element substantially parallel to said third coil element and a second connector portion joining said third coil element to said fourth coil element.

9. The method of claim 8 including

forming said first magnetic resonance coil in a position which is relatively offset from said second magnetic resonance coil.

10. The method of claim 8 including

deforming said circuit board into a substantially cylindrical shape.

11. The method of claim 8 including

deforming said circuit board so that a line drawn substantially perpendicular to said first coil element and said second coil element will be oriented substantially perpendicularly with respect to a line drawn substantially perpendicular to said third coil element and said fourth coil element.

12. The method of claim 11 including

deforming said circuit board so that the plane including said first coil element and said second coil element will be oriented substantially perpendicularly to the plane including said third coil element and said fourth coil element.

13. The method of claim 12 including said first coil element being aligned substantially parallel to said fourth coil element.

14. The method of claim 8 including

forming said second magnetic resonance coil so that a line drawn substantially perpendicular to said first coil element and said second coil element will be oriented substantially parallel with respect to a line drawn substantially perpendicular to said third coil element and said fourth coil element.

15. The method of claim 8 including

forming said second magnetic resonance coil on an opposing outer surface of said circuit board to said first magnetic resonance coil.

16. The method of claim 15 including

deforming said circuit board to establish a tubular coil structure having said first magnetic resonance coil along the exterior surface thereof and said second magnetic resonance coil along the interior surface thereof.

17. The method of claim 16 including

creating said tubular coil structure with each exterior coil element having an interior said coil element interposed circumferentially between it and the next adjacent exterior coil element.

18. The method of claim 16 including

establishing said tubular coil structure such that a line drawn substantially perpendicular to said first coil element and said second coil element will be oriented substantially perpendicularly with respect to a line drawn substantially perpendicular to said third coil element and said fourth coil element.

19. The method of claim 1 including

creating a decoupling circuit in electrical communication with said first magnetic resonance coil.

20. The method of claim 19 including

electrically interposing a tuning/matching circuit between said first magnetic resonance coil and said decoupling circuit.

21. The method of claim 19 including

providing at least two capacitors in said coil.

22. The method of claim 21 including

providing an electronic switch operatively associated with at least one said capacitor.

23. The method of claim 1 including

employing a preformed catheter in effecting said covering.

24. The method of claim 1 including

creating said catheter by applying a molten resinous material to effect said covering.

25. The method of claim 1 including

establishing capacitive tuning means on said circuit board.

26. The method of claim 25 including

tuning the magnetic resonance coil to a desired MR frequency by adjusting at least one of the following:

(a) said capacitive tuning means; and

(b) the length of said first coil element and said second coil element;

(c) the distance said second coil element is from said first coil element.

27. The method of claim 25 including

establishing said capacitive tuning means by electrodeposition on said circuit board.

28. The method of claim 25 including

employing said method to create a capacitive magnetic resonance coil.

29. The method of claim 25 including

employing said method to create a transmitting magnetic resonance coil.

30. The method of claim 25 including

employing said method to create a transmitting and receiving magnetic resonance coil.

31. The method of claim 1 wherein said forming comprises etching.

32. The method of claim 1 wherein said forming comprises electroplating.

33. The method of claim 1 wherein said forming includes providing electrically conductive inks.

34. The method of claim 1 wherein said forming includes

forming said first coil element with substantially uniform width.

35. A magnetic resonance catheter coil system comprising:

a catheter, said catheter having disposed therein

a flexible circuit board having a first outer surface with a first magnetic resonance coil formed thereon, said first magnetic resonance coil including,

a first coil element formed of electrically conductive material,

a second coil element formed of electrically conductive material and positioned substantially parallel to said first coil element,

a connector portion formed of electrically conductive material and joining

said first coil element and said second coil element.

36. The coil of claim 35 including

said circuit board substantially underlying said coil elements to create a unitary coil assembly.

37. The coil of claim 35 including

a plurality of magnetic resonance coils formed on said circuit board.

38. The coil of claim 35 including

said coil having an average width of about 0.2 to 10 mm.

39. The coil of claim 38 including

said coil having a thickness of about 0.1 to 5 mm.

40. The coil of claim 39 including

said coil having a length of about 1 to 30 cm.

41. The coil of claim 35 including

a second magnetic resonance coil formed on said circuit board, said second magnetic resonance coil comprising a third coil element and a fourth coil element substantially parallel to said third coil element and a second connector portion joining said third coil element to said fourth coil element.

42. The coil of claim 41 including

said second magnetic resonance coil being formed so that a line drawn substantially perpendicular to said first coil element and said second coil element will be oriented substantially parallel with respect to a line drawn substantially perpendicular to said third coil element and said fourth coil element.

43. The coil of claim 41 including

said circuit board being deformed so that a line drawn substantially perpendicular to said first coil element and said second coil element will be oriented substantially perpendicularly with respect to a line drawn substantially perpendicular to said third coil element and said fourth coil element.

44. The coil of claim 43 including

said circuit board being deformed so that the plane including said first coil element and said second coil element will be oriented substantially perpendicularly to the plane including said third coil element and said fourth coil element.

45. The coil of claim 44 including

said first coil element being aligned substantially parallel to said fourth coil element.

46. The coil of claim 41 including

said circuit board being deformed into a substantially cylindrical shape.

47. The coil of claim 41 including

said first magnetic resonance coil being in a position which is relatively offset from said second magnetic resonance coil.

48. The coil of claim 41 wherein

said second magnetic resonance coil is formed on an opposing outer surface of said circuit board relative to said first magnetic resonance coil.

49. The coil of claim 48 including

said circuit board being deformed into a tubular coil having said first magnetic resonance coil formed on the exterior surface thereof and said second magnetic resonance coil formed on the interior surface thereof.

50. The coil of claim 49 including

said tubular coil having a design such that a line drawn substantially perpendicular to said first coil element and said second coil element is oriented substantially perpendicularly with respect to a line drawn substantially perpendicular to said third coil element and said fourth coil element.

51. The coil of claim 49 including

said tubular coil with each exterior coil element having an interior said coil element interposed circumferentially between it and the next adjacent coil element.

52. The coil of claim 35 including

said first magnetic resonance coil being a capacitive magnetic resonance coil.

53. The coil of claim 35 including

said first magnetic resonance coil being a transmitting magnetic resonance coil.

54. The coil of claim 35 including

said first magnetic resonance coil being a transmitting and receiving magnetic resonance coil.

55. The coil of claim 35 including

a decoupling circuit disposed in electrical connection with said first magnetic resonance coil.

56. The coil of claim 55 including

a tuning/matching circuit electrically interposed between said first magnetic resonance coil and said decoupling circuit .

57. The coil of claim 55 including

at least two capacitors.

58. The coil of claim 57 including

an electronic switch operatively associated with at least one said capacitor.

59. The coil of claim 35 including

a preamplifier electrically disposed within said catheter and being connected to said first magnetic resonance coil.

60. The coil of claim 35 including

a preamplifier electrically connected to said first magnetic resonance coil and secured to said circuit board.

61. The coil of claim 35 including

said catheter being a preformed catheter.

62. The coil of claim 35 including

said catheter being created by applying a molten resinous material to said circuit board and said first magnetic resonance coil.

63. The coil of claim 35 further including capacitive tuning means.