Non-occlusive expandable catheter

• US 6,263,236 B1
• Filed: 11/29/1999
• Issued: 07/17/2001
• Est. Priority Date: 11/29/1999
• Status: Expired due to Fees

• Current Assignee: EndoVascular Technologies Incorporated (Boston Scientific Corporation)
• Original Assignee: Illumenex Corporation
• Inventors: Ziebol, Robert, Kasinkas, Michael
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US09/450,312
• Time in Patent Office: 596 Days
• Field of Search: 604/114, 604/113, 604/21, 604/96.01, 604/105-106, 604/107, 600/439, 606/32, 606/33, 606/41, 606/7, 606/8, 606/13-17, 607/80, 607/88
• US Class Current: 604/21
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 2017/22061 for spreading elements apart
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2017/22087 photodynamic
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61N 2005/1003 having means for centering a radioactive source within the lumen, e.g. balloons
• CPC Class Codes: A61N 2005/1021 Radioactive fluid
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

Non-occluding catheters and methods for delivering energy to a vessel wall without occluding blood flow through the vessel wall are disclosed. In particular, the invention uses an energy distributor connected to an expansion mechanism and a waveguide. The expansion mechanism causes the distributor to come into close proximity with a target region in the vessel wall, while maintaining at least one fluid passageway for blood flow throughout the instrument.

Claims

1. A catheter for applying energy to a wall of a vessel without occluding fluid flow comprising:

a hollow elongated instrument having a proximal end and a distal end at least one lumen therethrough, further comprising at least one waveguide disposed within the lumen, the waveguide having a proximal end and a distal end, the proximal end of the waveguide being adapted to receive energy from an energy source;

a distributor disposed of at the distal end of the instrument constructed to receive energy from the waveguide and distribute the energy into a target region of a vessel wall; and

an expansion mechanism connected to the distributor for expanding the energy distributor at the target region in order to bring the distributor into close proximity with the vessel wall while creating at least one fluid passageway through the distributor.

2. The catheter of claim 1, wherein the waveguide comprises at least one optical fiber.

3. The catheter of claim 1, wherein the waveguide comprises at least one electrical conductor.

4. The catheter of claim 1, wherein the waveguide comprises at least one thermal conductor.

5. The catheter of claim 1, wherein the distributor is a light distributor comprising at least one light diffuser.

6. The catheter of claim 5, wherein the light diffuser further comprises a light scattering material which directs light to the walls of the light diffuser.

7. The catheter of claim 6, wherein the light scattering material further comprises a polymeric material which has light scattering particles dispersed therein.

8. The catheter of claim 7, wherein the light scattering particles are selected from the group consisting of alumina, silica, and titania compounds and mixtures thereof.

9. The catheter of claim 6, wherein the light scattering material is coated on the inner side of the light diffuser.

10. The catheter of claim 1, wherein the distributor further comprises a sheath casing.

11. The catheter of claim 1, wherein the expansion mechanism comprises a flexible spring expander.

12. The catheter of claim 1, wherein the expansion mechanism comprises a coil expander.

13. The catheter of claim 1, wherein the expansion mechanism a shape-memory material.

14. The catheter of claim 1 wherein the catheter further comprises at least one conduit for a fluid medium and at least one port on the distributor to release the fluid medium.

15. The catheter of claim 1, further comprising a control mechanism to activate the expansion mechanism from a contracted state to an expanded state.

16. A method for delivering energy to the walls of a vessel without occluding fluid flow comprising:

inserting a catheter into the lumen of the vessel, the catheter comprising an elongated hollow instrument having a proximal end and distal end and further comprising a waveguide disposed within the lumen, the waveguide having a proximal end and a distal end, the proximal end of the waveguide being adapted for receiving energy from an energy source and delivering energy to the interior of, a distributor at the distal end of the waveguide, the distributor being constructed for receiving energy from the waveguide and for distributing energy to a target region of a vessel wall, and an expansion mechanism connected to the energy distributor for expanding the distributor at the target region;

activating the expansion mechanism, thereby expanding the energy distributor at the target region and creating at least one fluid passageway through the distributor; and

transmitting the energy from the distributor to the target region.

17. The method of claim 16, wherein the step of delivering energy further comprises irradiating with light.

18. The method of claim 16, wherein the step of delivering energy further comprises transmitting phototherapeutic radiation via a plurality of optical fibers.

19. The method of claim 16, wherein the method further comprises delivering energy to a vessel to treat a region.

20. The method of claim 19, further comprising treating a region wherein the region is an aneurysm.

21. The method of claim 19, further comprising treating a region wherein the region is an atherosclerotic plaque.

22. The method of claim 16, wherein the step of transmitting energy further comprises irradiating the target region with light.

23. The method of claim 16, wherein the step of transmitting energy further comprises heating or cooling a target region.

24. A method for treating a region in a vessel without occluding fluid flow comprising:

administering a therapeutically effective amount of a therapeutic agent to the subject;

inserting a catheter into the lumen of the vessel, the catheter comprising an elongated hollow instrument having a proximal end and distal end and further comprising a waveguide disposed within the lumen, the waveguide having a proximal end and a distal end, the proximal end of the waveguide being adapted for receiving energy from an energy source and delivering energy to the interior of, a distributor at the distal end of the waveguide, the distributor being constructed for receiving energy from the waveguide and for distributing energy to a target region of a vessel wall, and an expansion mechanism connected to the energy distributor for expanding the distributor at the target region;

activating the expansion mechanism, thereby expanding the energy distributor at the target region and creating at least one fluid passageway through the distributor; and

transmitting energy to the target region via the distributor that modulates the therapeutic agent such that the therapeutic agent alters the target region, thereby treating the region.

25. The method of claim 24, further comprising treating a region wherein the region is an aneurysm.

26. The method of claim 24, further comprising treating a region wherein the region is an atherosclerotic plaque.

27. The method of claim 24, wherein the step of administering a therapeutic agent comprises administering a therapeutic agent selected from the group consisting of a photoactivatable agent and a thermoactivatable agent.

28. The method of claim 24, wherein the step of administering further comprises systemically administering the therapeutic agent.

29. The method of claim 24, wherein the step or administering further comprises locally administering the therapeutic agent.

30. The method of claim 24, wherein the stop of delivering energy further comprises irradiating with light.

31. The method of claim 24, wherein the step of transmitting energy further comprises heating the region.

32. The method of claim 24, wherein the step of transmitting energy further comprises cooling the region.

33. A catheter for applying energy to a wall of a vessel without occluding fluid flow comprising:

a hollow elongated instrument having a proximal end and a distal end;

a distributor disposed of at the distal end of the instrument, wherein the distribute comprises a source of ionizing radiation, and is constructed to distribute the radiation into a target region of a vessel wall; and

an expansion mechanism connected to the distributor for expanding the distributor at the target region in order to bring the distributor into close proximity with the vessel wall while creating at least one fluid passageway through the distributor.

34. The catheter of claim 33, wherein the source of ionizing radiation is a liquid radiation source.

35. The catheter of claim 34, wherein the liquid radiation source is a liquid radioisotope.

36. The catheter of claim 33, wherein the source of ionizing radiation is a solid radiation source.

37. The catheter of claim 36, wherein the solid radiation source is a radioactive pellet.

38. The catheter of claim 33, wherein the distributor further comprises a sheath casing.

39. The catheter of claim 33, wherein the expansion mechanism comprises a flexible spring expander.

40. The catheter of claim 33, wherein the expansion mechanism comprises a coil expander.

41. The catheter of claim 33, wherein the expansion mechanism a shape-memory material.

42. The catheter of claim 33, wherein the catheter further comprises at least one conduit for a fluid medium and at least one port on the distributor to release the fluid medium.

43. The catheter of claim 33, further comprising a control mechanism to activate the expansion mechanism from a contracted state to an expanded state.

44. A method for delivering energy to the walls of a vessel without occluding fluid flow comprising:

inserting a catheter into the lumen of the vessel, the catheter comprising an elongated hollow instrument having a proximal end and distal end, and a distributor comprising a source of ionizing radiation, wherein the distributer is constructed to distribute the radiation to a target region of a vessel wall, and an expansion mechanism connected to the radiation distributor for expanding the distributor at the target region;

activating the expansion mechanism, thereby expanding the energy distributor at the target region and creating at least one fluid passageway through the distributor; and

transmitting the radiation emitted by the source of ionizing radiation from the distributor to the target region.

45. The method of claim 44, wherein the method further comprises delivering energy to a vessel to treat a regions.

46. The method of claim 44, further comprising treating a region wherein the region is an aneurysm.

47. The method of claim 44, further comprising treating a region wherein the region is an atherosclerotic plaque.

48. A method for treating a region in a vessel without occluding fluid flow comprising:

administering a therapeutically effective amount of a therapeutic agent to the subject;

inserting a catheter into the lumen of the vessel, the catheter comprising an elongated hollow instrument having a proximal end and distal end, and a distributor comprising a source of ionizing radiation, wherein the distributer is constructed to distribute the radiation to a target region of a vessel wall, and an expansion mechanism connected to the radiation distributor for expanding the distributor at the target region;

activating the expansion mechanism, thereby expanding the energy distributor at the target region and creating at least one fluid passageway through the distributor; and

transmitting the radiation emitted by the source of ionizing radiation to the target region via the distributor that modulates the therapeutic agent such that the therapeutic agent alters the target region, thereby treating the region.

49. The method of claim 48, further comprising treating a region wherein the region is an aneurysm.

50. The method of claim 48, further comprising treating a region wherein the region is an atherosclerotic plaque.

51. The method of claim 48, wherein the step of administering a therapeutic agent comprises administering a therapeutic agent selected from the group consisting of a photoactivatable agent and a thermoactivatable agent.

52. The method of claim 48, wherein the step of administering further comprises systemically administering the therapeutic agent.

53. The method of claim 48, wherein the step or administering further comprises locally administering the therapeutic agent.

54. The method of claim 48, wherein the step of transmitting the radiation emitted by the source of ionizing radiation further comprises heating the region.

55. The method of claim 48, wherein the step of transmitting the radiation emitted by the source of ionizing radiation further comprises cooling the region.