Techniques for treating anxiety disorders by brain stimulation and drug infusion

• US 6,263,237 B1
• Filed: 02/14/2000
• Issued: 07/17/2001
• Est. Priority Date: 05/01/1997
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rise, Mark T.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/503,530
• Time in Patent Office: 519 Days
• Field of Search: 617/3-5, 617/45, 617/72, 617/115-117, 617/120, 617/153, 128/898, 604/20, 604/21, 604/49-53, 604/890.1, 604/891.1, 604/892.11, 604/65-67, 604/93, 604/246
• US Class Current: 607/3
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

Techniques using one or more drugs and/or electrical stimulation for treating an anxiety disorder by means of an implantable signal generator and electrode and/or an implantable pump and catheter. A catheter is surgically implanted in the brain to infuse the drugs, and one or more electrodes may be surgically implanted in the brain to provide electrical stimulation.

Claims

1. A method of using one or more drugs to therapeutically treat an anxiety disorder by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, the method comprising the steps of:

surgically implanting the catheter so that the discharge portion lies in a brain parenchyma; and

,

operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site, whereby an anxiety disorder is treated.

2. The method of claim 1 wherein the step of surgically implanting comprises surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties.

3. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the anterior limb of the internal capsule.

4. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the head of the caudate nucleus.

5. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the cingulum fibers.

6. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter in the cingulate gyrus.

7. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the dorsal medial nucleus of thalamus.

8. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the locus ceruleus.

9. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the amygdyla.

10. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the dorsal raphe nucleus.

11. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the septum.

12. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the frontal cortex.

13. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the anterior thalamus.

14. The method of claim 2 wherein the step of surgically implanting the catheter adjacent a predetermined infusion site in the brain tissue chosen to have anxiolytic properties comprises the step of surgically implanting the catheter at the mammillary body.

15. The method of claim 1 further comprising the step of sensing physiological parameters of a heightened state of anxiety.

16. The method of claim 15 wherein the step of operating the pump includes the step of controlling the operation of the pump, in response to the step of sensing physiological parameters, to discharge a predetermined dosage of the one or more drugs when a physiological parameter is detected.

17. A method of using one or more drugs to therapeutically treat an anxiety disorder by means of a static device capable of storing and releasing the one or more drugs when implanted in the central nervous system, the method comprising the steps of:

surgically implanting the static device so that the one or more drugs may be released in the central nervous system;

providing an electrical signal generator and an implantable electrode having a proximal end and a stimulation portion, the proximal end of the electrode coupled to the signal generator;

surgically implanting the electrode so that the stimulation portion may stimulate a site in a central nervous system chosen to have anxiolytic properties;

operating the signal generator to stimulate the chosen site in the central nervous system; and

,

treating an anxiety disorder with the drug that may be released into the central nervous system and stimulating the chosen site in the central nervous system.

18. The method of claim 17 further comprising the steps of:

sensing physiological parameters of a heightened state of anxiety; and

wherein said step of operating the signal generator includes the step of operating the signal generator in response to the step of sensing physiological parameters, whereby the electrical signal produced by the signal generator is regulated in accordance with the physiological parameter detected.

19. The method of claim 18 wherein the step of sensing physiological parameters includes the step of implanting a sensor capable of sensing physiological parameters.

20. A method of using one or more drugs to therapeutically treat an anxiety disorder by means of an implantable pump and a catheter having a proximal end coupled to the pump and a discharge portion for infusing therapeutic dosages of the one or more drugs, the method comprising the steps of:

surgically implanting the catheter so that the discharge portion lies in an intrathecal space of a spinal cord; and

,

operating the pump to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site, whereby an anxiety disorder is treated.