Implantable stimulation device and method for determining atrial autocapture using PVC response

• US 6,263,244 B1
• Filed: 09/15/1999
• Issued: 07/17/2001
• Est. Priority Date: 05/14/1996
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Levine, Paul A., Mann, Brian M., Endaya, Melinda
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/396,223
• Time in Patent Office: 671 Days
• Field of Search: 607/14, 607/27, 607/28
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/3714 Atrial capture
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

A pacemaker programmer and diagnostic system retrieves information stored within a pacemaker and analyzes the retrieved data in real time. The stored information can be retrieved by means of a telemetry communication link. The pacemaker automatically lengthens a post-ventricular atrial refractory period (PVARP). The pacemaker determines atrial capture threshold by generating atrial stimulation pulses while maintaining the ventricular stimulation pulse amplitude at a level known to ensure ventricular capture, and by detecting loss of atrial capture. In response to loss of atrial capture, a processor automatically triggers a premature ventricular contraction (PVC) response to prevent a retrograde P-wave from initiating a pacemaker-mediated tachycardia. Also in response to loss of atrial capture, the processor sets the atrial stimulation pulse amplitude to a value above the atrial capture threshold in a subsequent cardiac cycle, and restores the PVARP to its pre-test value.

Claims

1. A method of determining an atrial capture threshold in a stimulation device having a premature ventricular contraction (PVC) response, comprising:

generating an atrial stimulation pulse while maintaining ventricular stimulation pulse amplitude at a level known to ensure ventricular capture;

detecting loss of capture of the atrial stimulation pulse; and

in response to loss of capture, automatically triggering the premature ventricular contraction response to prevent a retrograde P-wave from initiating a pacemaker-mediated tachycardia (PMT).

2. The method, as recited in claim 1, further including restoring the atrial stimulation pulse amplitude to a value above the atrial capture threshold in a subsequent cardiac cycle.

3. The method, as recited in claim 2, further including:

retrieving historical data from the stimulation device to estimate an atrial stimulation pulse amplitude at which loss of capture would occur; and

determining an initial atrial stimulation pulse amplitude based on the atrial stimulation pulse amplitude estimated from the historical data.

4. The method, as recited in claim 3, wherein generating the atrial stimulation pulse includes setting the amplitude of the initial atrial stimulation pulse to a predetermined level above the estimated atrial stimulation pulse amplitude.

5. The method, as recited in claim 4, wherein setting the amplitude of the initial atrial stimulation pulse includes increasing the amplitude of the initial atrial stimulation pulse a step immediately above the estimated atrial stimulation pulse amplitude.

6. The method, as recited in claim 1, wherein the stimulation device has an adjustable post-ventricular atrial refractory period (PVARP), and further including lengthening the PVARP before detecting loss of capture.

7. The method, as recited in claim 6, wherein lengthening the PVARP includes increasing the PVARP to a programmed value.

8. The method, as recited in claim 1, wherein lengthening the PVARP includes incrementally increasing the PVARP.

9. The method, as recited in claim 1, wherein if loss of capture is detected, setting a capture threshold as the atrial stimulation pulse amplitude at which loss of capture occurs.

10. The method, as recited in claim 9, further including setting the atrial stimulation pulse amplitude to a value within a safety margin above the capture threshold.

11. The method, as recited in claim 10, further including restoring the PVARP to a base value in response to loss of capture.

12. The method, as recited in claim 1, wherein detecting loss of capture includes using an ECG signal.

13. The method, as recited in claim 12, wherein detecting loss of capture further includes generating a marker channel indicative of stimulation pulse timing and comparing the marker channel to the ECG signal.

14. A stimulation device for determining an atrial capture threshold having a premature ventricular contraction (PVC) response, comprising:

a pulse generator for generating an atrial stimulation pulse while maintaining ventricular stimulation pulse amplitude at a level known to ensure ventricular capture;

detection circuitry coupled to the pulse generator for detecting loss of capture of the atrial stimulation pulse; and

a processor, coupled to the pulse generator and the detection circuitry, for automatically triggering the premature ventricular contraction response, in response to loss of capture, to prevent a retrograde P-wave from initiating a pacemaker-mediated tachycardia (PMT).

15. The stimulation device, as recited in claim 14, wherein the processor restores the atrial stimulation pulse amplitude to a value above the atrial capture threshold in a subsequent cardiac cycle.

16. The stimulation device, as recited in claim 15, further including memory for storing historical data;

wherein the processor retrieves the historical data; and

wherein based on the historical data, the processor estimates an atrial stimulation pulse amplitude at which loss of capture would occur, and sets the amplitude of the initial atrial stimulation pulse to a predetermined level above the estimated atrial stimulation pulse amplitude.

17. The stimulation device, as recited in claim 15, having an adjustable post-ventricular atrial refractory period (PVARP), and further including a timing circuitry;

wherein the timing circuit lengthens the PVARP prior to the detection circuitry detecting loss of capture; and

wherein the timing circuit restores the PVARP to a base value in response to loss of capture.

18. The stimulation device, as recited in claim 15, wherein if the detection circuitry does not detect loss of capture, a timing circuitry decreases an atrial stimulation pulse amplitude until loss of capture is detected.

19. The stimulation device, as recited in claim 15, wherein the processor includes control circuitry;

wherein if loss of capture is detected, the control circuitry sets a capture threshold as the atrial stimulation pulse amplitude at which loss of capture occurs; and

wherein the control circuitry sets the atrial stimulation pulse amplitude to a value within a safety margin above the capture threshold.

20. The stimulation device, as recited in claim 15, wherein the stimulation device is a dual-chamber implantable cardiac pacing device.

21. A stimulation device for determining an atrial capture threshold having a premature ventricular contraction (PVC) response, comprising:

a pulse generator for generating an atrial stimulation pulse while maintaining ventricular stimulation pulse amplitude at a level known to ensure ventricular capture;

detection means coupled to the pulse generator, for detecting loss of capture of the atrial stimulation pulse; and

processing means, coupled to the pulse generator and the detection means, for automatically triggering the premature ventricular contraction response, in response to loss of capture, to prevent a retrograde P-wave from initiating a pacemaker-mediated tachycardia (PMT).

22. The stimulation device, as recited in claim 21, wherein the processing means restores the atrial stimulation pulse amplitude to a value above the atrial capture threshold in a subsequent cardiac cycle.

23. The stimulation device, as recited in claim 22, wherein, in response to loss of capture, the timing circuit restores PVARP to a base value.