In-situ radioactive medical device
First Claim
1. A medical device adapted for placement at an intravascular treatment site to inhibit restenosis, the device comprising:
- a device surface;
a first substance immobilized on said device surface; and
a radioactive second substance suitable for intravascular injection, wherein said first substance is adapted to bind said radioactive second substance when said second substance is intravascularly injected.
4 Assignments
0 Petitions
Accused Products
Abstract
Devices and methods for rendering an intravascular stent radioactive in-situ, after stent placement. A stent is provided having a tubular body and a first substance immobilized on body. The first substance preferably has a high and selective affinity for a second substance which can be radioactive, cytotoxic or thrombolytic. The first substance can also have an affinity for growth factors or thrombolytic, chemolytic or cytotoxic agents. The stent can be placed across a stenosed blood vessel region, preferably after dilation by angioplasty or atherectomy. After stent placement within the vessel, the second substance can be injected into the blood stream of a patient. With each pass through the stent, the second substance is increasingly bound to the first substance on the stent. Suitable complementary substance pairs include avidin and radio-labeled biotin, protamine and radioactive heparin, and protein and anti-protein antibody.
194 Citations
47 Claims
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1. A medical device adapted for placement at an intravascular treatment site to inhibit restenosis, the device comprising:
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a device surface;
a first substance immobilized on said device surface; and
a radioactive second substance suitable for intravascular injection, wherein said first substance is adapted to bind said radioactive second substance when said second substance is intravascularly injected. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 38, 39, 40, 41, 42, 43, 44, 45)
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13. A medical device adapted for placement at an intravascular treatment site to inhibit restenosis, the device comprising:
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a device surface;
a first substance immobilized on said device surface; and
a radioactive second substance suitable for intravascular injection, wherein said first substance is adapted to bind said radioactive second substance when said second substance is intravascularly injected, said second substance being selectively and strongly bound to said first substance. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A kit for inhibiting restenois in blood vessels comprising:
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a stent including a tubular body, and a first substance immobilized on said tubular body; and
a second substance adapted to bind to said first substance when said second substance is intravascularly injected, said second substance being radioactive, said substance being suitable for injection into the human blood stream. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. A system for inhibiting restenosis in blood vessels comprising:
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a radioactive substance suitable for injection into the human blood stream; and
a stent including a tubular body, and means for binding said radioactive substance when said radioactive substance is intravascularly injected, said binding means being immobilized on said tubular body.
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29. A method for inhibiting restenosis in a stenosed blood vessel region of a patient comprising the steps:
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providing a radioactive substance suitable for injection into the human blood stream;
providing a medical device having a surface and means for binding said radioactive substance, said binding means connected to said surface;
placing said device across said stenosed region;
injecting said radioactive substance into the blood stream, such that said radioactive substance is bound to said binding means. - View Dependent Claims (30, 31)
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32. A method for inhibiting restenosis in a stenosed blood vessel region of a patient comprising the steps:
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providing a medical device having a surface and a first substance immobilized on said surface;
providing a second substance suitable for injection into the human blood stream, said second substance being radioactive;
placing said medical device at said stenosed region;
injecting said second substance into the blood stream, such that said second substance is substantially bound to said first substance. - View Dependent Claims (33, 34, 35, 46)
providing a third substance suitable for injection into the human blood stream, said third substance being non-radioactive and adapted to bind to said first substance;
injecting said third substance into the blood stream such that said third substance is substantially bound to said first substance.
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36. A medical device adapted for intravascular placement comprising:
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a device surface;
a first substance immobilized on said surface; and
a second substance suitable for intravascular injection, wherein said first substance is adapted to bind said second substance strongly and selectively when said second substance is intravascularly injected, and wherein said second substance is selected from the group consisting of cytotoxic substances, growth factors, thrombolytic agents and anti-thrombogenic agents.
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37. A method for inhibiting restenosis in a stenosed blood vessel region of a patient comprising the steps:
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providing a medical device having a surface and a first substance immobilized on said surface;
providing a second substance suitable for injection into the human blood stream, wherein said second substance is selected from the group consisting of cytotoxic substances, growth factors, thrombolytic agents and anti-thrombogenic agents;
placing said medical device at said stenosed region; and
injecting said second substance into said blood stream, such that said second substance is bound to said first substance. - View Dependent Claims (47)
providing a third substance suitable for injection into the human blood stream, said third substance being radioactive and adapted to bind to said first substance;
injecting said third substance into the blood stream such that said third substance is substantially bound to said first substance.
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Specification