Combined ultrasound and near infrared diffused light imaging system

• US 6,264,610 B1
• Filed: 05/05/2000
• Issued: 07/24/2001
• Est. Priority Date: 05/05/1999
• Status: Expired due to Term

• Current Assignee: University of Connecticut (State of Connecticut)
• Original Assignee: University of Connecticut (State of Connecticut)
• Inventors: Zhu, Quing
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): PATEL, MAULIN M
• Application Number:
  US09/565,508
• Time in Patent Office: 445 Days
• Field of Search: 600/437, 600/407, 600/443, 600/447, 600/448, 600/438
• US Class Current: 600/443
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: A61B 8/0825 for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/5238 for combining image data of patient, e.g. merging several images from different acquisition modes into one image for image registration algorithms G06T7/30

Abstract

A combined ultrasound and near infrared (NIR) diffused light imaging system includes a combined ultrasound and NIR light probe operatively connected to an ultrasound imaging system and an NIR diffused light imaging system. The combined ultrasound and NIR light probe comprises ultrasound transducer elements distributed in a rectangular matrix. Each element works in pulse-echo mode to provide spatial images of tissue at various depths. The optical system includes laser diode light sources and photomultiplier tube detectors. Measurement can be done at multiple source-detector positions to develop image-reconstruction schemes to determine absorption and scattering coefficients as well as oxygen and blood concentration of the tissue volume at various slice depths. A display device provides co-registration of acoustic and optical images output by the ultrasound and NIR diffused light imaging systems.

Claims

1. A combined ultrasound and diffused light probe for use in imaging of a medium, the combined ultrasound and diffused light probe comprising:

a plurality of ultrasound transducer elements configured to receive ultrasound echoes from the medium and transform the ultrasound echoes into electrical signals;

a near-infrared light source positioned proximate to said plurality of ultrasound transducer elements, said near-infrared light source being configured to project photon diffusion waves into the medium; and

a near-infrared light detector positioned proximate to said plurality of ultrasound transducer elements, said near-infrared light detector being configured to receive reflected photon diffusion waves from the medium.

2. The combined ultrasound and diffused light probe of claim 1, wherein said plurality of ultrasound transducer elements is formed in a two-dimensional array.

3. The combined ultrasound and diffused light probe of claim 1, wherein said plurality of ultrasound transducer elements is formed in array having dimensions selected from the group including one-dimensional, 1.5-dimensional, and 1.75-dimensional.

4. The combined ultrasound and diffused light probe of claim 1, wherein said plurality of ultrasound transducer elements is positioned between said nearinfrared light source and said near-infrared light detector.

5. The combined ultrasound and diffused light probe of claim 1, further comprising:

a plurality of near-infrared light sources distributed around said plurality of ultrasound transducer elements; and

a plurality of near-infrared light sensors distributed around said plurality of ultrasound transducer elements.

6. A combined ultrasound and diffused light imaging system for imaging a tissue volume, said combined ultrasound and diffused light imaging system comprising:

a probe including

a plurality of ultrasound transducer elements configured to receive ultrasound echoes from the tissue volume and to transform the ultrasound echoes into electrical signals,

a near-infrared light source positioned proximate to said plurality of ultrasound transducer elements, said near-infrared light source being configured to project photon diffusion waves into the tissue volume, and

a near-infrared light detector positioned proximate to said plurality of ultrasound transducer elements, said near-infrared light detector being configured to receive reflected photon diffusion waves from the tissue volume;

a near-infrared light imaging system configured to receive said reflected photon diffusion waves from said near-infrared light detector and provide a first image of the tissue volume; and

an ultrasound imaging system configured to receive said electrical signals and provide a second image of the tissue volume.

7. The combined ultrasound and diffused light imaging system of claim 6, wherein said plurality of ultrasound transducer elements is formed in a two-dimensional array.

8. The combined ultrasound and diffused light imaging system of claim 6, wherein said plurality of ultrasound transducer elements is formed in array having dimensions selected from the group including one-dimensional, 1.5-dimensional, and 1.75-dimensional.

9. The combined ultrasound and diffused light imaging system of claim 6, wherein said plurality of ultrasound transducer elements is positioned between said near-infrared light source and said near-infrared light detector.

10. The combined ultrasound and diffused light imaging system of claim 6, wherein said probe further includes:

a plurality of near-infrared light sources distributed around said plurality of ultrasound transducer elements; and

a plurality of near-infrared light detectors distributed around said plurality of ultrasound transducer elements.

11. The combined ultrasound and diffused light imaging system of claim 6, wherein said first and second images are provided on a single display.

12. The combined ultrasound and diffused light imaging system of claim 6, wherein said first and second images have the same scale.

13. The combined ultrasound and diffused light imaging system of claim 6, wherein said first and second images have the same grayscale and/or color scheme.

14. The combined ultrasound and diffused light imaging system of claim 6, wherein the said first and second images each include an image of a target within the tissue volume, the image of the target being positioned in the same location in said first and second images.

15. A combined ultrasound and diffused light imaging system for imaging a tissue volume, said combined ultrasound and diffused light imaging system comprising:

a near-infrared light imaging system configured to provide a first image of the tissue volume; and

an ultrasound imaging system configured provide a second image of the tissue volume, wherein said first and second images are provided on a single display.

16. The combined ultrasound and diffused light imaging system of claim 15, wherein said first and second images have the same scale.

17. The combined ultrasound and diffused light imaging system of claim 15, wherein said first and second images have the same grayscale and/or color scheme.

18. The combined ultrasound and diffused light imaging system of claim 15, wherein the said first and second images each include an image of a target within the tissue volume, the image of the target being positioned in the same location in said first and second images.