System and method for providing quantified and qualitative hand analysis

• US 6,264,621 B1
• Filed: 10/29/1999
• Issued: 07/24/2001
• Est. Priority Date: 10/29/1999
• Status: Expired due to Term

• Current Assignee: William C. Paske
• Original Assignee: William C. Paske
• Inventors: Paske, William C.
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): WINGOOD, PAMELA LYNN
• Application Number:
  US09/430,184
• Time in Patent Office: 634 Days
• Field of Search: 600/587, 600/595, 600/592
• US Class Current: 600/587
• CPC Class Codes: A61B 5/225 of the fingers, e.g. by monitoring hand-grip force
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4528 Joints A61B5/4533, A61B5/4538 take precedence

Abstract

A non-invasive system and method are provided for determining the presence or absence of neural, muscular, soft tissue, bone or joint damage or other disease affecting a person'"'"'s hand. A preferred system includes a plurality of digit contact members, one of which is engageable by the person'"'"'s thumb and others which are engageable by other digits of the hand, at least one of the other digits being innervated by the ulnar nerve. Force detectors are operatively connected to at least two of the digit contact members for measuring the quantity of force applied to the respective digit contact members by at least one digit innervated by the median nerve and a digit innervated by the ulnar nerve, as they engage in a natural gripping motion. The measured forces may be used to calculate quality indices useful in the diagnosis of disease and the monitoring of progression of disease.

Claims

1. A method for qualitatively evaluating a digital performance of a person comprising:

measuring a first applied force as a function of time, said force being applied by a thumb to a first force detector, to determine a first data set;

measuring a second applied force as a function of time, said force being applied by a digit innervated by the median nerve to a second force detector, to determine a second data set;

measuring a third applied force as a function of time, said force being applied by a digit innervated by the ulnar nerve to a third force detector, to determine a third data set; and

cross-correlating the first second and third data sets to create a patient digital performance profile.

2. The method of claim 1 wherein the patient digital performance profile comprises one or more quality indices.

3. The method of claim 2 wherein the quality indices indicate presence or absence of injury.

4. The method of claim 1 further comprising the step of comparing the patient digital performance profile to a plurality of diagnostic digital performance profiles, each of said diagnostic digital performance profiles corresponding to a different disease.

5. The method of claim 1 further comprising the step of comparing the patient digital performance profile to a previous digital performance profile for said patient for the same hand.

6. The method of claim 1 further comprising the step of comparing the patient digital performance profile to a subsequent digital performance profile for said patient for the same hand.

7. The method of claim 1 further comprising the step of comparing the patient digital performance profile to a digital performance profile for said patient for the opposite hand.

8. The method of claim 1 wherein the first, second and third applied forces are measured during the same time interval.

9. The method of claim 1 wherein said first, second and third applied forces as a function of time are selected from the group consisting of forces exerted by the digits during a sustained grip, during a plurality of repeated gripping and releasing motions, during a plurality of repeated gripping and releasing motions in response to a signal, and combinations of one or more thereof.

10. The method of claim 1 wherein the steps of measuring the first, second and third applied forces further comprise measuring displacement caused by the forces applied by the thumb, the digit innervated by the median nerve and the digit innervated by the ulnar nerve.

11. A method for qualitatively evaluating a digital performance of a person to detect disease comprising:

measuring a first applied force as a function of time, said force being applied by a thumb to a first force detector, to determine a first data set;

measuring a second applied force as a function of time, said force being applied by a digit innervated by the median nerve to a second force detector, to determine a second data set;

measuring a third applied force as a function of time, said force being applied by a digit innervated by the ulnar nerve to a third force detector, to determine a third data set;

substituting all or a portion of said first, second and third data sets into one or more quality index formulas to determine one or more patient quality indices;

comparing the one or more patient quality indices to a plurality of diagnostic quality indices, each of said diagnostic quality indices corresponding to a different disease; and

detecting the presence of disease.

12. The method of claim 11 wherein the step of detecting comprises detecting the type of disease.

13. The method of claim 11 wherein the step of detecting comprises detecting severity of disease.

14. The method of claim 11 wherein a said first, second and third applied forces as a function of time are selected from the group consisting of forces exerted by the digits during a sustained grip, during a plurality of repeated gripping and releasing motions, during a plurality of repeated gripping and releasing motions in response to a signal, and combinations of one or more thereof.

15. The method of claim 11 wherein said one or more quality index formulas are derived from the formula:

$Q<br><br>\text{\hspace{1em}<br><br>}<br><br>I=c·<br><br>{\left({\left(\frac{P_i-P_{i+1}}{P_i}\right)}^j+{\left(\frac{P_i-P_{i+2}}{P_i}\right)}^j+{\left(\frac{P_{i+1}-P_{i+2}}{P_i}\right)}^j\right)}^{\frac{1}{n}}$

where;

QI=the quality index value,

c=multiplier chosen to normalize the quality index,

p_i=measured parameter for the first of the tested digits,

p_i+1=measured parameter for the second of the tested digits,

p_i+2=measured parameter for the third of the tested digits,

j=2, 4, 6 . . . , and

n=1, 2, 3 . . . .

16. The method of claim 15 wherein n=2 and c=1.

17. The method of claim 11 wherein said first, second and third applied forces comprise a force exerted by the respective digit during multiple pulses of gripping and releasing, and wherein one of said one or more quality index formulas comprises a formula for calculating an applied force time dependent attenuation (decay) index (QID), said formula comprising:

$Q<br><br>\text{\hspace{1em}<br><br>}<br><br>I_D=c·<br><br>{\left({\left(\frac{m<br><br>\text{\hspace{1em}<br><br>}<br><br>t-m<br><br>\text{\hspace{1em}<br><br>}<br><br>i}{m<br><br>\text{\hspace{1em}<br><br>}<br><br>t}\right)}^2+{\left(\frac{m<br><br>\text{\hspace{1em}<br><br>}<br><br>t-\mathrm{m5}}{m<br><br>\text{\hspace{1em}<br><br>}<br><br>t}\right)}^2+{\left(\frac{m<br><br>\text{\hspace{1em}<br><br>}<br><br>i-\mathrm{m5}}{m<br><br>\text{\hspace{1em}<br><br>}<br><br>t}\right)}^2\right)}^{\frac{1}{n}}$

where;

c=the multiplier chosen to normalize the quality index,

mt=exponential decay slope of the first digit,

mi=exponential decay slope of the second digit,

m5=exponential decay slope of the fifth digit, and

n=1, 2, 3 . . . .

18. The method of claim 11 wherein said first, second and third applied forces comprise a sustained force exerted by the respective digit during multiple pulses of gripping and releasing, and wherein one of said one or more quality index formulas comprises a formula for calculating a linear correlation coefficient (QI_r), said formula comprising:

$Q<br><br>\text{\hspace{1em}<br><br>}<br><br>I_r=c·<br><br>{\left({\left(\frac{\mathrm{rit}-\mathrm{r5t}}{\mathrm{rit}}\right)}^2+{\left(\frac{\mathrm{ri5}-\mathrm{rit}}{\mathrm{rit}}\right)}^2+{\left(\frac{\mathrm{ri5}-\mathrm{r5t}}{\mathrm{rit}}\right)}^2\right)}^{\frac{1}{n}}$

where;

c=the multiplier chosen to normalize the quality index,

rit=Pearson'"'"'s linear correlation coefficient between the first digit and second digit,

r5t=Pearson'"'"'s linear correlation coefficient between the first digit and fifth digit,

ri5=Pearson'"'"'s linear correlation coefficient between the second digit and fifth digit, and

n=1, 2, 3 . . . .

19. The method of claim 11 wherein said first, second and third applied forces comprise a force exerted by the respective digit during multiple pulses of attempted uniform gripping and releasing, and wherein one of said one or more quality index formulas comprises a formula for calculating a pulse width uncertainty correlation coefficient (QI_pw, said formula comprising:

$\begin{array}{c}Q<br><br>\text{\hspace{1em}<br><br>}<br><br>I_{\mathrm{pw}}=\text{\hspace{1em}<br><br>}<br><br>c·<br><br>\\ \text{\hspace{1em}<br><br>}<br><br>{\left({\left(\frac{\mathrm{sdwT}-\mathrm{sdwI}}{\mathrm{sdwT}}\right)}^2+{\left(\frac{\mathrm{sdwT}-\mathrm{sdw5}}{\mathrm{sdwT}}\right)}^2+{\left(\frac{\mathrm{sdwI}-\mathrm{sdw5}}{\mathrm{sdwT}}\right)}^2\right)}^{\frac{1}{n}}\end{array}$

where;

c=the multiplier chosen to normalize the quality index,

sdwT=standard deviation of the full pulse width at half maximum for the first digit,

sdwI=standard deviation of the full pulse width at half maximum for the second digit,

sdw5=standard deviation of the full pulse width at half maximum for the fifth digit, and

n=1, 2, 3 . . . .

20. The method of claim 11 wherein said first, second and third applied forces comprise a force exerted by the respective digit during multiple pulses of gripping and releasing in response to a stimulus, and wherein one of said one or more quality index formulas comprises a formula for calculating a pulse onset correlation coefficient (QI_po), said formula comprising:

$Q<br><br>\text{\hspace{1em}<br><br>}<br><br>I_{\mathrm{po}}=c·<br><br>{\left({\left(\frac{\mathrm{OtT}-\mathrm{OtI}}{\mathrm{OtT}}\right)}^2+{\left(\frac{\mathrm{OtT}-\mathrm{Ot5}}{\mathrm{OtT}}\right)}^2+{\left(\frac{\mathrm{Ot5}-\mathrm{OtI}}{\mathrm{OtT}}\right)}^2\right)}^{\frac{1}{n}}$

where;

c=the multiplier chosen to normalize the quality index,

OtT=standard deviation of the differential pulse onset time for the first digit,

OtI=standard deviation of the differential pulse onset time for the second digit,

Ot5=standard deviation of the differential pulse onset time for the fifth digit, and

n=1, 2, 3 . . . .

21. The method of claim 11 wherein said first, second and third applied forces comprise a maximum measured force exerted by the respective digit during multiple pulses of gripping and releasing, and wherein one of said one or more quality index formulas comprises a formula for calculating a mean maximum applied force correlation coefficient (QI_MF), said formula comprising:

$\begin{array}{c}Q<br><br>\text{\hspace{1em}<br><br>}<br><br>I_{\mathrm{MF}}=\text{\hspace{1em}<br><br>}<br><br>c·<br><br>({\left(\frac{\mathrm{mfTsd}-\mathrm{mfIsd}}{\mathrm{mfTsd}}\right)}^2+\\ {\text{\hspace{1em}<br><br>}<br><br>{\left(\frac{\mathrm{mfTsd}-\mathrm{mf5sd}}{\mathrm{mfTsd}}\right)}^2+{\left(\frac{\mathrm{mf5sd}-\mathrm{mfIsd}}{\mathrm{mfTsd}}\right)}^2)}^{\frac{1}{n}}\end{array}$

where;

c=the multiplier chosen to normalize the quality index,

mfTsd=standard deviation of the differential maximum applied force by the first digit,

mfIsd=standard deviation of the differential maximum applied force by the second digit,

mf5sd=standard deviation of the differential maximum applied force by the fifth digit, and

n=1, 2, 3 . . . .

22. The method of claim 11 wherein said first, second and third applied forces comprise a minimum applied force exerted by the respective digit during multiple pulses of gripping and releasing, and wherein one of said one or more quality index formulas comprises a formula for calculating a mean minimum applied force correlation coefficient, said formula comprising:

$\begin{array}{c}Q<br><br>\text{\hspace{1em}<br><br>}<br><br>I_{\mathrm{RF}}=\text{\hspace{1em}<br><br>}<br><br>c·<br><br>({\left(\frac{\mathrm{mrTsd}-\mathrm{mrIsd}}{\mathrm{mrTsd}}\right)}^2+\\ {\text{\hspace{1em}<br><br>}<br><br>{\left(\frac{\mathrm{mrTsd}-\mathrm{mr5sd}}{\mathrm{mrTsd}}\right)}^2+{\left(\frac{\mathrm{mr5sd}-\mathrm{mrIsd}}{\mathrm{mrTsd}}\right)}^2)}^{\frac{1}{n}}\end{array}$

where;

c=the multiplier chosen to normalize the quality index,

mrTsd=standard deviation of the differential resting applied force for the first digit,

mrIsd=standard deviation of the differential resting applied force for the second digit,

mr5sd=standard deviation of the differential resting applied force for the fifth digit, and

n=1, 2, 3 . . . .

23. A method for evaluating a digital performance of a person to detect disease comprising:

evaluating the relative strength, relative coordination and relative fatigue rates of a digit innervated by the median nerve and a digit innervated by the ulnar nerve to obtain a patient performance data set; and

comparing the patient performance data set to a plurality of data sets characteristic of the digital performance of normal individuals and individuals suffering from different diseases in order to determine a disease status of the person.

24. The method of claim 23 wherein the disease status is the presence or absence of detectable disease.

25. The method of claim 23 wherein the detectable disease is selected from the group consisting of carpal tunnel syndrome, multiple sclerosis, ALS, Parkinson'"'"'s disease, polio and thoracic outlet syndrome.

26. A diagnostic profile library for diagnosing the presence or absence of disease in a patient based on a digital performance of a patient, comprising a plurality of diagnostic digital performance profiles, each of said diagnostic digital performance profiles correlating with the presence of a different disease, said diagnostic digital performance profiles determined by evaluating performance of a median nerve innervated digit and an ulnar nerve innervated digit for each of a plurality of persons having been diagnosed with said disease and determining the characteristics of the diagnostic performance profile correlatable with said disease.

27. A data base comprising a plurality of data sets as measured from a plurality of patients, said data sets each comprising measurements of the relative strength, relative coordination and relative fatigue rates of a digit innervated by the median nerve and a digit innervated by the ulnar nerve for each of said plurality of patients.

28. The data base of claim 27 wherein each data set is cross-correlated for an identified physical condition.

29. The data base of claim 27 wherein said data base further comprises means for receiving electronic data from at least one remote location, said data comprising a measurement of relative strength, relative coordination, and relative fatigue rates of a digit innervated by the median nerve and a digit innervated by the ulnar nerve of a patient;

means for comparing the data to the plurality of data sets to determine a result, said result comprising one or more physical conditions correlatable with said data; and

means for transmitting said result to said remote location.

30. An apparatus for evaluating the digital performance of a hand to detect disease comprising:

a plurality of digit contact members for engagement with the digits of the hand, said plurality of digit contact members comprising

a thumb contact member engageable by the thumb of the hand and

a lateral digit contact member engageable by a lateral digit of the hand, said lateral digit being innervated in whole or in part by the ulnar nerve;

a plurality of force detector means, said plurality of force detector means comprising

a first force detector means operatively connected to the lateral digit contact member and

a second force detector means operatively connected to a digit contact member engaged by a medial digit, said medial digit being innervated in whole or in part by the median nerve, each of said force detector means adapted to measure the quantity of force applied to the respective contact member and producing an output indicative of said quantity of force.

31. The apparatus of claim 30 wherein said first and second force detector means further comprise means for measuring force as a function of time.

32. The apparatus of claim 30 wherein said medial digit is the thumb and said second force detector means is operatively connected to the thumb contact member.

33. The apparatus of claim 30 wherein said medial digit is the second digit and said plurality of digit contact members further comprises a medial digit contact member and wherein said second force detector means is operatively connected to said medial digit contact member.

34. The apparatus of claim 30 wherein said plurality of digit contact members further comprises a medial digit contact member and wherein said second force detector means is operatively connected to said medial digit contact member and wherein said plurality of force detector means further comprises a third force detector means operatively connected to said thumb contact member.

35. The apparatus of claim 30 wherein said lateral digit is the fourth or fifth digit of the hand.

36. The apparatus of claim 30 wherein said median nerve innervated digit is the thumb, the second digit, the third digit or the fourth digit of the hand.

37. The apparatus of claim 30 further comprising means for displaying said outputs.

38. The apparatus of claim 30 further comprising means for measuring the relative strength of the lateral digit and the medial digit.

39. The apparatus of claim 30 further comprising means for measuring the absolute strength of the lateral digit and the medial digit.

40. The apparatus of claim 30 further comprising means for assessing relative coordination between the lateral digit and the medial digit.

41. The apparatus of claim 30 further comprising means for measuring fatigue rate of the lateral digit and the medial digit.

42. The apparatus of claim 30 wherein said disease is soft tissue disease, bone disease or a combination thereof.

43. The apparatus of claim 30 wherein said soft tissue disease is selected from the group consisting of neural disease, muscular disease, connective tissue disease, or a combination thereof.

44. The apparatus of claim 30 wherein said neural disease is selected from the group consisting of multiple sclerosis, carpal tunnel syndrome, ALS, Parkinson'"'"'s disease, polio or thoracic outlet syndrome.

45. The apparatus of claim 30 wherein said each of said force detector means is adapted to measure displacement caused by the force exerted by its respective digit.