Ocular insert
First Claim
1. A flexible ocular insert device adapted for the controlled sustained release of a drug upon insertion into the upper or lower fornix of the eye, said device comprising an elongate body of a polymeric material including two end portions said body containing a pharmaceutically active ingredient, said device having a length of at least 8 mm and a maximum diameter not exceeding 1.9 mm, wherein said device is sufficiently flexible to allow it to bend along the curvature of the eye within the upper or lower fornix upon being positioned so that the longitudinal axis of said device is generally parallel to the transverse diameter of the eyeball, the device does not extend onto any visible portion of the eyeball, and in which each of said end portions is tapered towards the extremities of the device.
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Accused Products
Abstract
A flexible ocular insert device adapted for the controlled sustained release of a drug upon insertion into the upper or lower fornix of the eye. The device comprises an elongate body of a polymeric material including two end portions, wherein the body contains a pharmaceutically active ingredient, and wherein the device has a length of at least 8 mm and a maximum diameter not exceeding 1.9 mm. The device is sufficiently flexible to allow it to bend along the curvature of the eye within the upper or lower fornix upon its being positioned so that the longitudinal axis of the device is generally parallel to the transverse diameter of the eyeball, and the device does not extend onto any visible portion of the eyeball. Each of the end portions of the device is tapered towards the extremities of the device.
137 Citations
32 Claims
- 1. A flexible ocular insert device adapted for the controlled sustained release of a drug upon insertion into the upper or lower fornix of the eye, said device comprising an elongate body of a polymeric material including two end portions said body containing a pharmaceutically active ingredient, said device having a length of at least 8 mm and a maximum diameter not exceeding 1.9 mm, wherein said device is sufficiently flexible to allow it to bend along the curvature of the eye within the upper or lower fornix upon being positioned so that the longitudinal axis of said device is generally parallel to the transverse diameter of the eyeball, the device does not extend onto any visible portion of the eyeball, and in which each of said end portions is tapered towards the extremities of the device.
- 15. A device adapted for the controlled sustained release of two or more drugs upon insertion into the upper or lower fornix of the eye, said device comprising an elongated body of a polymeric material including two end portions said body containing pharmaceutically active ingredient, said device having a length of at least 8 mm and a maximum diameter not exceeding 1.9 mm, wherein said device is sufficiently flexible to allow it to bend along the curvature of the eye within the upper or lower fornix upon being positioned so that the longitudinal axis of said device is generally parallel to the transverse diameter of the eyeball, and which at least two distinct portions of the device include respective distinct ones of said drugs.
Specification