Transdermal resorption of active substances from supercooled masses of levulic acid

• US 6,264,980 B1
• Filed: 11/07/1997
• Issued: 07/24/2001
• Est. Priority Date: 12/24/1994
• Status: Expired due to Term

• Current Assignee: Purdue Pharma L.P.
• Original Assignee: LTS Lohmann Therapie-Systeme GmbH
• Inventors: Hille, Thomas
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): CHANNAVAJJALA, LAKSHMI SARADA
• Application Number:
  US08/860,961
• Time in Patent Office: 1,355 Days
• Field of Search: 424/448, 424/449, 514/567, 514/946
• US Class Current: 424/449
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7061 Polyacrylates

Abstract

A pharmaceutical product for the release of medicinal agents to the skin having absorption-increasing auxiliary agents is characterized in that the auxiliary material forms subcooled melts.

Claims

1. In a drug composition for the release of a medicinal agent to the skin which comprises a medicinal agent and at least one auxiliary agent having an absorption-increasing effect, the improvement wherein the auxiliary agent having an absorption-increasing effect is levulic acid in a subcooled melt.

2. A drug composition for the release of a medicinal agent to the skin which comprises a medicinal agent and at least one auxiliary agent having an absorption increasing effect, wherein the auxiliary agent having an absorption increasing effect is levulic acid and the medicinal agent is buprenorphine base.

3. In a drug composition for the release of a medicinal agent transdermally which comprises a medicinal agent and at least one auxiliary agent having an absorption increasing effect, the improvement wherein the auxiliary agent having an absorption-increasing effect is levulic acid in a subcooled melt.

4. A drug composition for the release of a medicinal agent transdermally which comprises a medicinal agent and at least one auxiliary agent having an absorption increasing effect, wherein the auxiliary agent having an absorption-increasing effect is levulic acid and the medicinal agent is buprenorphine base.