Herbal composition for reducing inflammation and methods of using same

• US 6,264,995 B1
• Filed: 02/25/2000
• Issued: 07/24/2001
• Est. Priority Date: 10/19/1999
• Status: Expired due to Term

• Current Assignee: New Chapter, Inc. (The Procter & Gamble Company)
• Original Assignee: New Chapter, Inc. (The Procter & Gamble Company)
• Inventors: Newmark, Thomas, Schulick, Paul
• Primary Examiner(s): Weber, Jon P.
• Assistant Examiner(s): Patten, Patrice A.
• Application Number:
  US09/512,673
• Time in Patent Office: 515 Days
• Field of Search: 424/195.1, 424/725, 424/729, 424/756, 424/773, 424/779, 424/774
• US Class Current: 424/725
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/29 Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
• CPC Class Codes: A61K 36/53 Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 36/539 Scutellaria (skullcap)
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/9066 Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

Abstract

An herbal composition reducing inflammation in bones and joints by inhibiting the enzyme cyclooxygenase-2 is prepared from holy basil, turmeric, ginger, green tea, rosemary, huzhang, Chinese goldthread, barberry, oregano and scutellariae baicalensis. More particularly, the herbal composition of the present invention contains therapeutically effective amounts of the supercritical extracts of ginger, rosemary and oregano, and therapeutically effective amounts of extracts of holy basil, turmeric, green tea, huzhang, Chinese goldthread, barberry, rosemary and scutellariae baicalensis. The herbal composition can be administered orally, topically or parenterally. Particularly preferred embodiments are soft gel capsules for oral administration and creams for topical application. In addition to reducing inflammation, the herbal composition also promotes healthy joint function and, because it inhibits cyclooxygenase-2 (COX-2), the composition also promotes normal cell growth. Furthermore, the herbal composition contains organic anti-aging constituents that inactivate oxygen free radicals, thereby providing antioxidant benefits in addition to anti-inflammatory benefits.

Claims

1. An anti-inflammatory herbal composition, comprising about 13% by weight of a supercritical carbon dioxide of ginger, about 13% by weight of a supercritical carbon dioxide extract of rosemary;

about 13% by weight of a supercritical carbon dioxide extract of oregano;

about 13% by weight of an alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract of holy basil;

about 13% by weight of an alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract of turmeric;

about 13% by weight of an alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract of green tea;

about 10.4% by weight of an alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract of huzhang;

about 13% by weight of an alcoholic, aqueous, or hydroalcoholic extract of rosemary about 5.2% by weight of an alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract of Chinese goldthread;

about 5.2% by weight of an alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract of barbeny; and

about 2.6% by weight of an alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract of scutellariae.

2. A composition according to claim 1, wherein the composition is an orally administered composition.

3. A composition according to claim 2, wherein the orally administered composition is in a form selected from the group consisting of capsules, tablets, elixirs, powders, granules, suspensions, sachets, food additives, beverage additives, and tea.

4. A composition according to claim 2, wherein the orally administered composition is in the form of two soft gel capsules.

5. A composition according to claim 1, wherein the composition is a topically administered composition.

6. A composition according to claim 5, wherein the topically administered composition is in a form selected from the group consisting of lotions, ointments, gels, creams, suppositories, drops, liquids, sprays and powders.

7. A composition according to claim 6, wherein the topically administered composition is in the form of a cream.

8. A composition according to claim 1, wherein:

the holy basil leaf alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract contains about 2% by weight of ursolic acid;

the turmeric rhizome alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract contains about 7% by weight of curcumin;

the ginger rhizome supercritical carbon dioxide extract contains about 5% by weight of zingiberene;

the green tea leaf alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract contains about 45% by weight of polyphenols;

the rosemary leaf and essential oil supercritical carbon dioxide extract contains about 23% by weight of phenolic antioxidants;

the huzhang alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract contains about 8% by weight of resveratrol;

the Chinese goldthread root alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract contains about 6% by weight of berberine;

the barberry root alcoholic, aqueous, hydroalcoholic or supercritical carbon dioxide extract contains about 6% by weight of berberine; and

the oregano leaf supercritical carbon dioxide extract contains about 0.8% by weight of phenolic antioxidants.

9. A composition according to claim 1, further comprising olive oil, yellow beeswax, gelatin, glycerine, purified water and carob.

10. A composition according to claim 1, wherein the composition is a parenterally administered composition.