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Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases

  • US 6,265,172 B1
  • Filed: 02/08/2000
  • Issued: 07/24/2001
  • Est. Priority Date: 02/08/1999
  • Status: Expired due to Fees
First Claim
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1. A method for detecting the presence of mutation within the MnSOD gene promoter region wherein the mutation is associated with cancer comprising:

  • (i) carrying out restriction fragment length polymorphism analysis on a DNA test sample;

    (ii) obtaining a restriction endonuclease digestion pattern from the procedure in step (i); and

    (iii) comparing results obtained in step (ii) with restriction endonuclease digestion pattern of a wild-type MnSOD gene promoter, wherein a difference in the restriction endonuclease digestion pattern indicates the presence of at least one mutation in the MnSOD gene promoter in the DNA test sample wherein the mutation is associated with cancer.

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