Method for evaluating atherosclerosis and its affect on the elasticity of arterial walls

• US 6,267,728 B1
• Filed: 06/23/1999
• Issued: 07/31/2001
• Est. Priority Date: 06/23/1999
• Status: Expired due to Fees

• Current Assignee: Mark Hayden
• Original Assignee: Mark Hayden
• Inventors: Hayden, Steven Mark
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): SZMAL, BRIAN SCOTT
• Application Number:
  US09/339,283
• Time in Patent Office: 769 Days
• Field of Search: 600/481, 600/454, 600/437, 600/455
• US Class Current: 600/481
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces

Abstract

A method for evaluating atherosclerosis using M-Mode ultrasound to measure atherosclerotic plaques and their affect on compliance of the arterial walls in peripheral arteries. Movement of the arterial walls is measured during a systolic-diastolic pressure cycle and the intimal medial thickness and the thickness of any atherosclerotic lesions are measured as well. The method measures the distance between the near and far walls of the subject artery and the acoustic impedance of the materials that comprise the individual layers of the arterial walls. To image an artery with M-Mode ultrasound, a transducer head having at least one transmitting element and at least one receiving element is placed against a patient'"'"'s skin adjacent the peripheral artery to be evaluated. A repeating series of sound pulses are transmitted from the transmitting element into the patient substantially perpendicular to the subject artery. The sound waves are reflected to varying degrees by the tissues encountered and the reflected waves are measured by the receiving element(s) in the transducer head. M-Mode ultrasound allows for continuous monitoring of the position of the arterial walls during the systolic-diastolic pressure cycle such that changes in position of the arterial wall can be measured over a predetermined period of time.

Claims

1. A method for evaluating atherosclerosis in an artery, comprising the steps of:

a. locating an artery;

b. transmitting M-Mode sound waves transversely through the artery such that said sound waves pass through opposing walls of the artery;

c. detecting M-Mode sound waves reflected from the opposing walls; and

d. evaluating said detected sound waves to determine the thickness of the opposing walls and diameter of the artery.

2. A method according to claim 1, wherein the artery is located in step (a) using B-Mode sound waves.

3. A method according to claim 1, wherein said M-Mode sound waves are transmitted in step (b) through the longitudinal axis of the artery.

4. A method according to claim 1, wherein steps (a) to (d) are performed during a systolic-diastolic pressure wave cycle.

5. A method according to claim 1, wherein steps (a) to (d) are performed during a time period comprising a plurality of systolic-diastolic pressure wave cycles.

6. A method for measuring thickness of the intimal layer of an arterial wall to evaluate atherosclerosis in an artery, comprising the steps of:

a. locating an artery;

b. transmitting M-Mode sound waves transversely through the artery such that said sound waves pass through the intimal layer of an arterial wall;

c. detecting M-Mode sound waves reflected from the intimal layer; and

d. evaluating said detected sound waves to determine the thickness of the intimal layer and the degree of atherosclerosis in the artery.

7. A method according to claim 6, wherein the artery is located in step (a) using B-Mode sound waves.

8. A method according to claim 6, wherein said M-Mode sound waves are transmitted in step (b) through the longitudinal axis of the artery.

9. A method according to claim 6, wherein steps (a) to (d) are performed during a systolic-diastolic pressure wave cycle.

10. A method according to claim 6, wherein steps (a) to (d) are performed during a time period comprising a plurality of systolic-diastolic pressure wave cycles.

11. A method for evaluating compliance of an artery, comprising the steps of:

a. locating an artery;

b. transmitting M-Mode sound waves through the artery during a time period comprising a plurality of systolic-diastolic pressure wave cycles, wherein said sound waves are transmitted transversely through the longitudinal axis of the artery such that said sound waves pass through opposing walls of the artery;

c. detecting M-Mode sound waves reflected from the opposing walls; and

d. evaluating said detected sound waves to determine changes in diameter of the artery during the systolic-diastolic pressure wave cycles.

12. A method according to claim 11, wherein the artery is located in step (a) using B-Mode sound waves.

13. A method according to claim 11, further comprising the step of (e) measuring the time period from a heart contraction to arrival of the corresponding systolic-diastolic pressure wave at a location of detection of said reflected M-Mode sound waves to evaluate compliance of arteries between the heart and the location of detection of said reflected M-Mode sound waves.