Pacing systems for treating functional ventricular conduction abnormalities of intrinsic origin

• US 6,267,778 B1
• Filed: 04/12/1999
• Issued: 07/31/2001
• Est. Priority Date: 04/12/1999
• Status: Active Grant

• Current Assignee: Fred Michael Cohen
• Original Assignee: Fred Michael Cohen
• Inventors: Cohen, Fred Michael
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/290,097
• Time in Patent Office: 841 Days
• Field of Search: 607/9, 607/25, 607/26, 600/516, 600/517, 600/521
• US Class Current: 607/9
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371

Abstract

Therapeutic implantable cardiac pacing systems incorporating electrocardiographic acquisition and QRS discrimination circuitry, for the purpose of ventricular pacing during wide QRS complexes of intrinsic origin, in order to narrow the QRS complex. Resultant narrowing of the QRS complex increases coronary artery flow and electrode position is employed to improve ventricular motion in the treatment of functional ventricular abnormalities caused by wide QRS complexes.

Claims

1. Implantable cardiac electrical apparatus comprising:

means for acquiring, storing and displaying the electrocardiogram of a patient;

second means for detecting the onset of the QRS complex of intrinsic origin and differentiating between multiple QRS complexes of varying morphologies; and

third means for discriminating between the onsets of narrow and wide QRS complex morphologies of intrinsic origin.

2. Apparatus according to claim 1 additionally comprising a pacing system for employing said onset of a narrow QRS complex within a predetermined time interval to inhibit stimulation of the ventricular muscle at, at least one ventricular location, within said predetermined time interval;

for employing said onset of a wide QRS complex within said predetermined time interval to stimulate the ventricular muscle at, at least one said ventricular location, simultaneous with said onset of a wide QRS complex and employing the absence of said onset of any QRS complex within said predetermined time interval to stimulate the ventricles at, at least one said ventricular location.

3. A method for improving the ventricular function of the heart of a patient comprising the steps of:

(a) acquiring the electrocardiogram (EKG) of a patient;

(b) electronically analyzing said EKG to determine the onset of the QRS complex of intrinsic origin;

(c) placing at least one electrode to stimulate the ventricular muscle at, at least one location selected to shorten a wide QRS complex of intrinsic origin upon ventricular stimulation simultaneous with said onset of the QRS complex;

(d) electrically connecting at least one of said electrodes to a pacing system;

(e) employing said onset of the QRS complex within a predetermined time interval to stimulate the ventricular muscle at, at least one said ventricular location, simultaneous with said onset of the QRS complex and employing the absence of said onset of the QRS complex within said predetermined time interval to stimulate the ventricular muscle at, at least one said ventricular location.

4. The method of claim 3 wherein ventricular electrical activity at, at least one said ventricular electrode within said predetermined time interval inhibits the deliverance of said ventricular stimulation to at least one electrode.

5. The method of claim 4 wherein there is a delay interval between said onset of the QRS interval and said ventricular stimulation of at least one electrode.

6. The method of claim 5 wherein at least one said ventricular stimulation is inhibited by intrinsic electrical activity occurring at, at least one said electrode during said delay interval and predetermined interval.

7. The method of claim 3 wherein at least one said electrode is located on the endocardial surface of a ventricular chamber.

8. Cardiac electrical stimulation apparatus comprising;

first means for acquiring the electrocardiogram of a patient;

second means responsive to said first means for determining the onset of the QRS complex; and

third means having output means and responsive to said second means for providing at least one stimulating impulse to at least one ventricular location simultaneous with said onset of the QRS complex within a predetermined time interval and providing at least one stimulating impulse to at least one said ventricular location in the absence of said onset of the QRS complex within said predetermined time interval.

9. Apparatus according to claim 8 additionally comprising fourth means, to which said third means is responsive, for providing inhibition of at least one said stimulating impulse to at least one said ventricular location upon the detection of intrinsic ventricular activity at, at least one said ventricular location within said predetermined time interval.

10. Apparatus according to claim 9 additionally comprising fifth means, to which said third means is responsive, for providing a programmable delay interval between said onset of the QRS complex and at least one said stimulating impulse to at least one said ventricular location.

11. Apparatus according to claim 10 wherein the fourth is also means for sensing at least one ventricular depolarization of intrinsic origin and inhibiting at least one said stimulating impulse upon the occurrence of said ventricular depolarization of intrinsic origin during said delay interval and said predetermined interval.

12. Apparatus according to claim 11 additionally comprising sixth means for sensing at least one ventricular depolarization of intrinsic origin and inhibiting at least one said stimulating impulse upon the occurrence of said ventricular depolarization of intrinsic origin during said delay interval.

13. A method for improving the atrial and ventricular function of the heart of a patient comprising the steps of:

(a) acquiring the electrocardiogram (EKG) of a patient;

(b) electronically analyzing said EKG to determine the onset of the P wave of intrinsic origin;

(c) placing at least one electrode to stimulate the ventricular muscle;

(d) electrically connecting at least one of said ventricular electrodes to a pacing system;

(e) employing said onset of the P wave within a predetermined time interval to stimulate the ventricular muscle at, at least one said ventricular location, at a programmed delay interval from said onset of the P wave, in the absence of ventricular electrical activity at, at least one electrode during said predetermined interval and employing the absence of said onset of the P wave within said predetermined time interval to stimulate the ventricular muscle at, at least one said ventricular location at expiration of said predetermined interval.