Apparatus and method for evoking and capturing a sweat sample

• US 6,269,265 B1
• Filed: 02/22/2000
• Issued: 07/31/2001
• Est. Priority Date: 02/22/1999
• Status: Expired due to Term

• Current Assignee: WR Medical Electronics Company
• Original Assignee: WR Medical Electronics Company
• Inventors: Anderson, Paul J.
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US09/510,024
• Time in Patent Office: 525 Days
• Field of Search: 604/20, 604/22, 604/890.1, 604/891.1, 604/892.1, 604/304-308, 604/23, 604/24, 604/25, 604/26, 600/573, 600/575, 600/578, 600/580, 73/232, 73/232.2
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An apparatus and related method for evoking, capturing, and optionally measuring one or more parameters within a sweat sample on the surface of the skin. The apparatus includes the use of an iontophoresis chemical chamber adapted to evoke a sweat sample, the chemical chamber being matably attached to a skin capsule adapted to contain the evoked sample. The skin capsule, in turn, is provided with one or more sensors to permit the on site determination of a corresponding number of parameters within the sample.

Claims

1. An apparatus and method for evoking, capturing, and optionally measuring one or more parameters within a sweat sample, the apparatus comprising,

a) at least one skin capsule comprising

i) a capsule chamber adapted to be removably positioned in sealed contact with the skin, in order to contain sweat evoked from the underlying skin,

ii) one or more sensors operably connected to the capsule chamber and adapted to measure corresponding parameters within the capsule chamber itself,

iii) gas inlet and outlet conduits adapted to controllably deliver desiccated gas and recover gas from the capsule chamber, respectively, and

iv) an electrical contact adapted to receive electrical energy from a controller in order to deliver the energy to a corresponding iontophoretic active electrode contact,

b) at least one iontophoretic chemical chamber comprising

i) a biocompatible polymeric material forming a chamber adapted to be removably retained upon the skin of a patient,

ii) a stimulating agent stably retained within the chemical chamber in a manner that permits the agent to be make iontophoretic contact with the skin, and

iii) an iontophoretic active electrode contact, adapted to make contact with the electrical contact of the skin capsule, in order to form an active electrode for the delivery of stimulating agent from the chemical chamber and to the skin,

each chemical chamber being adapted to be affixed to a skin capsule in a manner that permits the resultant capsule/chemical chamber assembly to be operated in order to be positioned upon and evoke a sweat response from the skin, by iontophoretic delivery of the stimulating agent, and adapted, in turn, to contain a known volume of the sweat evoked, in the form of moisture within the capsule chamber, and

c) a controller adapted to control and coordinate the operation of the apparatus, including the iontophoretic chemical chamber and sensors.

2. An apparatus according to claim 1 further comprising at least one wet cell adapted to permit comparison to a known humidity standard, in order to calibrate the apparatus.

3. An apparatus according to claim 2 further comprising a number of storage fixtures equal to the number of skin capsules plus wet cells.

4. An apparatus according to claim 3 further comprising at least one return electrode, containing an electrolyte solution and adapted to be positioned upon the patient'"'"'s skin, preferably in an area remote from the chemical capsule, in order to permit iontophoresis of the stimulating agent by the application of direct current to the active electrode.

5. An apparatus according to claim 1 wherein the controller is a four channel controller and the apparatus comprises four skin capsules, and four corresponding iontophoretic chemical chambers.

6. An apparatus according to claim 1 wherein the stimulating agent is provided in the form of a gel and comprises acetylcholine.

11. A method for evoking, capturing, and optionally measuring one or more parameters within a sweat sample, the method comprising

a) providing an apparatus according to claim 1,

b) affixing the skin capsule(s) to the skin of a patient,

c) affixing the iontophoretic chemical chamber(s) to corresponding skin capsules,

c) operating the apparatus in order to evoke a sweat response and to determine one or more parameters within the evoked sweat by using of the sensor(s) within the skin capsule(s).

12. A method according to claim 11 wherein the method is used to measure and compare both resting sweat output and evoked sweat output, both in terms of both rate and volume.

7. An apparatus for capturing and measuring one or more parameters within a sweat sample, the apparatus comprising,

a) at least one skin capsule comprising

i) a capsule chamber adapted to be removably positioned in sealed contact with the skin, in order to contain sweat evoked from the underlying skin,

ii) one or more sensors operably connected to the capsule chamber and adapted to measure corresponding parameters within the capsule chamber itself;

and

iii) gas inlet and outlet conduits adapted to controllably deliver desiccated gas and recover gas from the capsule chamber, respectively, and

b) a controller adapted to control and coordinate the operation of the apparatus.

8. An apparatus according to claim 7 in combination with an exercise device, wherein the apparatus is adapted to capture and measure one or more parameters with in sweat produced in the course of exercise.

9. An apparatus according to claim 8 wherein the apparatus is provided in a form adapted to retrofit an existing exercise device.

10. An apparatus according to claim 8 wherein the apparatus is provided as an integral part of an exercise device.