Method of improving the adherence of certain crosslinked polymer coatings containing PEO or PVP to a substrate

• US 6,270,902 B1
• Filed: 04/23/1997
• Issued: 08/07/2001
• Est. Priority Date: 04/23/1997
• Status: Expired due to Term

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Hudson, John, Elton, Richard, Tedeschi, Eugene
• Primary Examiner(s): Nakarani, D. S.
• Application Number:
  US08/838,939
• Time in Patent Office: 1,567 Days
• Field of Search: 427/2.24, 427/2.25, 427/2.28, 427/2.3, 427/2.31, 427/301, 427/322, 427/407.1, 427/409, 427/533, 427/535, 427/536, 427/551, 428/423.1, 428/412, 428/423.3, 428/423.7, 428/423.9, 428/425.5, 428/425.6, 428/425.8
• US Class Current: 428/423.1
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: B05D 7/546 each layer being cured, at least partially, separately
• CPC Class Codes: C08L 71/00 Compositions of polyethers obtained by reactions forming an ether link in the main chain of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 75/00 Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
• CPC Class Codes: C09D 175/00 Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
• CPC Class Codes: Y10T 428/31507 Of polycarbonate
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31554 Next to second layer of polyamidoester
• CPC Class Codes: Y10T 428/31565 Next to polyester [polyethylene terephthalate, etc.]
• CPC Class Codes: Y10T 428/31569 Next to natural rubber
• CPC Class Codes: Y10T 428/31598 Next to silicon-containing [silicone, cement, etc.] layer
• CPC Class Codes: Y10T 428/31601 Quartz or glass
• CPC Class Codes: Y10T 428/31605 Next to free metal

Abstract

A two step method or process for improving the adherence or bonding of a lubricious coating of a crosslinked polyurethane, polyurea or polyurethaneurea/PEO or PVP coating to a substrate surface, said two step method comprising a first step of subjecting said surface to a surface preparation which results in the treated surface being provided with a functional tie layer containing functional groups for reaction with functional groups of a reaction mixture to be applied in a subsequent second step, which upon curing forms a crosslinked polyurethane, polyurea or polyurethaneurea/PEO or PVP coating and a second step of applying to said tie layer said reaction mixture and curing the reaction mixture. A medical device resulting from the above-described two step method.

Claims

1. A two step method or process for improving the adherence or bonding of a lubricious coating of a crosslinked polyurethane, polyurea or polyurethaneurea/PEO or PVP coating to a substrate surface, said two step method comprising a first step of subjecting said surface to a surface preparation which results in the treated surface being provided with a functional tie layer containing functional groups capable of forming covalent bonds with functional groups of a reaction mixture to be applied in a subsequent second step, which reaction mixture comprises a molecule having at least two unreacted isocyanate groups per molecule and PEO or PVP and which reaction mixture upon curing forms a crosslinked polyurethane, polyurea or polyurethaneurea/PEO or PVP coating and a second step of applying to said tie layer said reaction mixture, forming a covalent bond between said tie layer and said reaction mixture and curing the reaction mixture.

2. A two step method according to claim 1 wherein the surface preparation first step is chosen to provide the desired functional tie layer, selected from the group consisting of (1) an application of a suitable primer composition containing appropriate functional groups, (2) a high energy surface treatment which provides suitable functional groups, (3) an oxidation surface treatment which provides appropriate functional groups, (4) multi-layer extrusion which provides appropriate functional group, (5) an electrostatic deposition surface treatment which provides appropriate functional group and (6) use of heat activatable material providing appropriate functional groups.

3. A two step method according to claim 1 wherein the surface preparation step is an application of a suitable primer composition to said substrate.

4. A two step method according to claim 1 wherein the surface preparation step is an application of a suitable high energy surface treatment to said substrate.

5. A two step method according to claim 1 wherein the surface preparation step is an application of a suitable oxidation surface treatment to said substrate.

6. A two step method according to claim 1 wherein the surface preparation step is an application of a suitable multi-layer extrusion to said substrate.

7. A two step method according to claim 1 wherein the surface preparation step is an application of a suitable electrostatic deposition surface treatment to said substrate.

8. A two step method according to claim 1 wherein the surface preparation step is an application of a suitable heat activatable material to said substrate.

9. A two step method according to claim 1 wherein the lubricious coating that is formed upon curing is a crosslinked polyurethane/PEO or PVP coating.

10. A two step method according to claim 1 wherein the lubricious coating that is formed upon curing is a crosslinked polyurea/PEO or PVP coating.

11. A two step method according to claim 1 wherein the lubricious coating that is formed upon curing is a crosslinked polyurethaneurea/PEO or PVP coating.

12. The two step method or process for improving the adherence or bonding of a lubricous coating according to claim 1, wherein the functional tie layer is covalently bound to the substrate surface.

13. The method according to claim 1, wherein the lubricious coating formed by the reaction mixture has a weight ratio of the polyurethane, polyurea or polyurethaneurea to PEO or PVP in the range of 0.5 to 15.

18. The medical device according to claim 12, wherein the lubricious coating formed by the reaction mixture has a weight ratio of the polyurethane, polyurea or polyurethaneurea to PEO or PVP in the range of 0.5 to 15.

14. A medical device having on its outer surface a functionalized tie layer for improving the adherence thereto of a lubricious coating of a crosslinked polyurethane, polyurea or polyurethaneurea/PEO or PVP coating, said functionalized tie layer having functional groups for reaction with functional groups of a reaction mixture when applied thereto and which reaction mixture comprises a molecule having at least two unreacted isocyanate groups per molecule and PEO or PVP and which reaction mixture upon curing forms a crosslinked polyurethane, polyurea or polyurethaneurea/PEO or PVP.

15. A medical device according to claim 14 wherein the lubricious coating that is formed upon curing is a crosslinked polyurethane/PEO or PVP coating.

16. A medical device according to claim 14 wherein the lubricious coating that is formed upon curing is a crosslinked polyurea/PEO or PVP coating.

17. A medical device according to claim 14 wherein the lubricious coating that is formed upon curing is a crosslinked polyurethaneurea/PEO or PVP coating.