Microfluidic interconnects

• US 6,273,478 B1
• Filed: 03/30/1999
• Issued: 08/14/2001
• Est. Priority Date: 03/30/1999
• Status: Expired due to Fees

• Current Assignee: Lawrence Livermore National Security LLC (Government of the United States of America)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Krulevitch, Peter A., Benett, William J.
• Primary Examiner(s): Nicholson, Eric K.
• Application Number:
  US09/281,345
• Time in Patent Office: 868 Days
• Field of Search: 285/346, 285/379, 285/334.5, 285/234, 285/364, 285/338, 285/231
• US Class Current: 285/346
• CPC Class Codes: F15C 5/00 Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
• CPC Class Codes: F16L 19/0218 comprising only sealing rings
• CPC Class Codes: F16L 21/03 placed in the socket before connection F16L21/022, F16L21/025 take precedence

Abstract

A miniature connector for introducing microliter quantities of solutions into microfabricated fluidic devices, and which incorporates a molded ring or seal set into a ferrule cartridge, with or without a compression screw. The fluidic connector, for example, joins standard high pressure liquid chromatography (HPLC) tubing to 1 mm diameter holes in silicon or glass, enabling ml-sized volumes of sample solutions to be merged with μl-sized devices. The connector has many features, including ease of connect and disconnect; a small footprint which enables numerous connectors to be located in a small area; low dead volume; helium leak-tight; and tubing does not twist during connection. Thus the connector enables easy and effective change of microfluidic devices and introduction of different solutions in the devices.

Claims

1. A microfluidic interconnect comprising:

a member having an opening therein,

a tube located in said opening and having a reduced external diameter end section,

said tube additionally including at least one protruding section in said reduced diameter end section,

a molded ring defining a seal located in said opening in of said member, and having an internal enlarged section, when said tube is installed in said molded ring said protruding section of said tube is positioned in said enlarged section of said molded ring,

said molded ring being constructed to form a leak-tight seal adjacent an associated member and to provide mechanical retention of said tube,

a compression screw for compressing said molded ring, and

a ferrule retaining said molded ring at least partially within said ferrule.

2. The interconnect of claim 1, wherein compression screw is secured to said ferrule.

3. A microfluidic interconnect comprising:

a member having an opening therein,

a tube located in said opening and having a reduced external diameter end section,

said tube additionally including at least one protruding section in said reduced diameter end section,

a molded ring defining a seal located in said opening of said member, and having an internal enlarged section, when said tube is installed in said molded ring said protruding section of said tube is positioned in said enlarged section of said molded ring,

said molded ring being constructed to form a leak-tight seal adjacent an associated member and to provide mechanical retention of said tube, and

said tube additionally including an extended tip of a diameter less than said reduced external diameter end section.

4. The interconnect of claim 3 wherein said associated member includes an opening therein, and wherein said tip of said tube is positioned in said opening of said associated member.

5. A microfluidic interconnect comprising:

a member having an opening therein,

a tube located in said opening and having a reduced external diameter end section,

said tube additionally including at least one protruding section in said reduced diameter end section,

a molded ring defining a seal located in said opening of said member, and having an internal enlarged section, when said tube is installed in said molded ring said protruding section of said tube is positioned in said enlarged section of said molded ring,

said molded ring being constructed to form a leak-tight seal adjacent an associated member and to provide mechanical retention of said tube,

said molded ring being mounted at least partially within a cartridge and said cartridge being adopted to be mounted in an associated member into which said tube is inserted,

said cartridge comprising a body member having an opening therethrough and a plurality of different diameter sections located along said opening, and wherein said tube includes a plurality of different diameter sections, and wherein said tube, when inserted into said cartridge, is positioned such that certain of said different diameter sections of each of said cartridge and said tube are in contact.

6. The interconnect of claim 5, where in said molded ring is retained in said cartridge and wherein said cartridge is secured to a compression screw.

7. A microfluidic interconnect comprising:

a member having an opening therein,

a tube located in said opening and having a reduced external diameter end section,

said tube additionally including at least one protruding section in said reduced diameter end section, and

a molded ring defining a seal located in said opening of said member, and having an internal enlarged section, when said tube is installed in said molded ring said protruding section of said tube is positioned in said enlarged section of said molded ring,

said molded ring being constructed to form a leak-tight seal adjacent an associated member and to provide mechanical retention of said tube,

said molded ring being retained in a ferrule cartridge, and said tube includes a tip section having said protruding section, said protruding section of said tip of said tube being located in an indentation in said molded ring when said tube is inserted into said molded ring.

8. A miniature fluidic connector for providing leak-tight fluid interconnection between two abutting members,

a first member having a fluid passageway therein,

a second member abutting the first member and having an opening therein aligned with said fluid passageway of said first member,

said fluidic connector being located in said opening of said second member and including a tube having a reduced diameter section containing at least an external protruding section, and a molded ring having an internal indentation, whereby said protruding section of said tube is located in said internal indentation of said molded ring.

9. The connector of claim 8, wherein an end of said reduced diameter section of said tube abuts said first member and is aligned with said fluid passageway in said first member.

10. The connector of claim 8 wherein an end of said reduced diameter section of said tube extends into said fluid passageway in said first member.

11. The connector of claim 8, additionally including a cartridge mounted in said opening of said second member, said molded ring being located at least partially within said cartridge.

12. The connector of claim 11, additionally including a compression screw for maintaining said cartridge in said opening of said second member.

13. The connector of claim 12, wherein said compression screw is secured to said cartridge.

14. The connector of claim 8, wherein said first member comprises a microfluidic device and wherein said second member comprises a packaging for the microfluidic device.