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Microfluidic devices, systems and methods for performing integrated reactions and separations

  • US 6,274,089 B1
  • Filed: 06/08/1998
  • Issued: 08/14/2001
  • Est. Priority Date: 06/08/1998
  • Status: Expired due to Term
First Claim
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1. A microfluidic device for performing integrated reaction and separation operations, comprising:

  • a body structure having an integrated microscale channel network disposed therein;

    a reaction region within the integrated microscale channel network, the reaction region having a mixture of at least first and second reactants disposed in and flowing through the reaction region, the mixture interacting to produce one or more products, wherein the reaction region comprises a first fluid having a first conductivity to maintain contact between the first and second reactants flowing therethrough; and

    a separation region in the integrated channel network, the separation region in fluid communication with the reaction region and comprising a separation inducing buffer having a second conductivity that is lower than the first conductivity to separate the first reactant from the one or more products flowed therethrough.

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