Surface modified silicone drug depot

• US 6,274,159 B1
• Filed: 10/28/1999
• Issued: 08/14/2001
• Est. Priority Date: 10/28/1998
• Status: Expired due to Fees

• Current Assignee: University of Florida (State University System of Florida)
• Original Assignee: University of Florida (State University System of Florida)
• Inventors: Marotta, James S., Hardt, Nancy S., Batich, Christopher D.
• Primary Examiner(s): Azpuru, Carlos A.
• Application Number:
  US09/429,396
• Time in Patent Office: 656 Days
• Field of Search: 424/426, 523/114, 523/115, 604/16
• US Class Current: 424/426
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0039 Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
• CPC Class Codes: C03C 10/0009 containing silica as main constituent
• CPC Class Codes: C03C 3/097 containing phosphorus, niobium or tantalum

Abstract

An improved implantable pharmaceutical depot for the prolonged release of at least one biologically active substance, the depot comprising a polymeric carrier and the biologically active substance, the improvement wherein the depot is coated or surface modified with a biologically active and biocompatible glass, glass-ceramic or ceramic material, the coating or modified surface being capable of forming a bond to soft tissue upon implantation. Methods for forming the biologically active and biocompatible glass, glass-ceramic or ceramic coating or modified surface on the silicone based depot are also disclosed.

Claims

1. An improved pharmaceutical depot adapted for implantation in a human or non-human animal for the prolonged release therewithin of at least one biologically active substance, said depot comprising a silicone carrier and incorporated therein said biologically active substance, the improvement wherein said depot is coated with a biologically active and biocompatible glass, glass-ceramic or ceramic material comprising at least about 40 weight percent silicon dioxide, said glass coating being capable of forming a bond to soft tissue upon implantation.

2. The depot of claim 1 wherein said biologically active and biocompatible glass, glass-ceramic or ceramic has the following weight percentage composition:

3. The depot of claim 1 wherein said coating of said biologically active and biocompatible glass, glass-ceramic or ceramic has a thickness of from about 0.02 mm to about 1.0 mm.

4. The depot of claim 1 wherein said biologically active substance is a steroid, hormone, antibiotic, chemotherapeutical agent, prostaglandin, vitamin, contraceptive or behavior modification agent.