Dual sensor rate response pacemaker

• US 6,275,733 B1
• Filed: 06/16/1999
• Issued: 08/14/2001
• Est. Priority Date: 06/16/1999
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Greenhut, Saul E., Florio, Joseph J., Bornzin, Gene A., Park, Euljoon
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/334,861
• Time in Patent Office: 790 Days
• Field of Search: 607/9, 607/17, 607/18, 607/19, 607/20, 607/21, 607/22, 607/23, 607/24, 607/25, 607/26
• US Class Current: 607/18
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A pacing system which determines a dual indicated rate (DIR) corresponding to a desired pacing rate of the heart of the patient by selecting the maximum between an activity indicated rate (AIR) and a metabolic indicated rate (MIR). The activity indicated rate is a pacing rate that is determined based upon a well-known acceleration-based sensor. The metabolic indicated rate is a desired pacing rate of the heart as determined based upon a well-known metabolic sensor, such as a minute ventilation sensor. Determining the dual indicated rate by selecting between the two rates provided by these two sensors results in the advantageous use of the activity indicated rate during periods of low-level and brisk activity and the use of the metabolic indicated rate during periods of high exertion.

Claims

1. A pacing system comprising:

activity rate sensor means for generating an activity indicated rate signal dependent upon the sensed activity of the patient;

metabolic rate sensor means for generating a metabolic indicated rate signal dependent upon a metabolic demand of the patient in response to physical activity of the patient;

dual indicated rate determining means for determining, based upon the activity indicated rate signal and the metabolic indicated rate signal, a dual indicated rate for pacing the patient, wherein the dual indicated rate determining means sets the dual indicated rate to correspond to the greater of the activity indicated rate signal or the metabolic indicated rate signal, the dual indicated rate determining means otherwise setting the dual indicated rate as corresponding to a rest rate when either the activity indicated rate signal or the metabolic indicated rate signal indicates that the patient is at rest; and

pacing means for providing pacing signals to the heart of the patient in response to the determined dual indicated rate.

2. The system of claim 1, wherein the activity rate sensor means comprises an activity sensor that senses acceleration of the patient'"'"'s body in response to activity of the patient and generates the activity indicated rate signal therefrom.

3. The system of claim 2, wherein the metabolic rate sensor means comprises a transthoracic impedance measurement circuit that periodically obtains a transthoracic impedance measurement which is then used to determine a minute ventilation parameter upon which the metabolic indicated rate signal is based.

4. The system of claim 1, wherein the dual indicated rate determining means sets the dual indicated rate as corresponding to a rest rate that is equal to the larger of the activity indicated rate signal or the metabolic indicated rate signal when both the activity indicated rate signal and the metabolic indicated rate signal are indicating that the patient is at rest.

5. The system of claim 4, wherein the dual indicated rate determining means sets the dual indicated rate as corresponding to a rest rate that is equal to one of the activity indicated rate signal or the metabolic indicated rate signal when one of the activity indicated rate signals or the metabolic indicated rate signal is indicating that the patient is at rest.

6. The system of claim 4, wherein the preselected maximum value of the activity indicated rate signal is set by a treating physician at implantation of the pacing system into the patient.

7. The system of claim 1, wherein the dual indicated rate determining means limits the magnitude of the activity indicated rate signal to a preselected maximum value when the activity indicated rate signal exceeds the preselected maximum value prior to the dual indicated rate determining means setting the dual indicated rate as corresponding to the greater of the activity indicated rate signal or the metabolic indicated rate signal, such that if the metabolic indicated rate signal exceeds the preselected maximum value of the activity indicated rate signal, the dual indicated rate determining means sets the dual indicated rate as corresponding to the metabolic indicated rate signal.

8. The system of claim 7, wherein the preselected maximum value of the activity indicated rate signal (CAIR) is determined according to the following formula:

9. The system of claim 1, wherein the dual indicated rate determining means determines whether the activity indicated rate signal is less than a preselected threshold value when the metabolic indicated rate signal exceeds a preselected threshold value and sets the dual indicated rate as being equal to an intermediate value selected to be between the metabolic indicated rate signal and the activity indicated rate signal.

10. The system of claim 9, wherein the dual indicated rate determining means continues to set the dual indicated rate at an intermediate value until the metabolic indicated rate signal decreases below the preselected threshold so that the pacing signals are provided to the heart at a progressively slower rate.

11. An implantable pacing system for providing pacing pulses to a patient, the system comprising:

at least one lead adapted to be implanted adjacent the heart of the patient so as to be able to deliver pacing pulses to the heart of the patient;

an activity sensor adapted to be implanted within the body of the patient, wherein the activity sensor periodically produces an activity signal corresponding to the sensed level of activity of the patient;

a metabolic sensor adapted to be implanted within the body of the patient, wherein the metabolic sensor periodically produces a metabolic signal corresponding to the sensed metabolic demand of the patient;

a control unit adapted to be implanted within the body of the patient, wherein the control unit receives the activity signal and periodically determines an activity indicated rate therefrom indicative of a pacing rate corresponding to the sensed level of activity of the patient, wherein the control unit also receives the metabolic signal and periodically determines a metabolic indicated rate therefrom indicative of a pacing rate corresponding to the sensed metabolic demand of the patient, wherein the metabolic indicated rate and the activity indicated rate are scaled so as to correspond to each other and wherein the control unit periodically determines a dual indicated rate by selecting the greater of the activity indicated rate and the metabolic indicated rate, wherein the activity indicated rate is generally more indicative of the patient'"'"'s physiological need during periods of low exercise and initiation of exercise and is selected to have a higher magnitude than the metabolic indicated rate during these periods such that during periods of low exercise and initiation of exercise, the dual indicated rate generally corresponds to the activity indicated rate and induces the delivery of pacing pulses to the heart of the patient via the at least one lead so that the heart rate of the heart is maintained at a rate corresponding to the dual indicated rate.

12. The pacing system of claim 11, wherein the activity sensor is comprised of a sensor that senses the acceleration of the patient'"'"'s body in response to activity of the patient.

13. The pacing system of claim 11, wherein the metabolic sensor comprises a transthoracic impedance measurement circuit that periodically measures the transthoracic impedance that is indicative of a minute ventilation parameter of the patient.

14. The pacing system of claim 11, wherein the activity indicated rate is generally more indicative of the patient'"'"'s physiological need during periods of low exercise and initiation of exercise and is selected to have a higher magnitude than the metabolic indicated rate during these periods such that during periods of low exercise and initiation of exercise, the dual indicated rate generally corresponds to the activity indicated rate.

15. The pacing system of claim 11, wherein the metabolic indicated rate generally is more indicative of the patient'"'"'s physiological need during periods of high exertion exercise and is selected to have a higher magnitude than the activity indicated rate during these periods such that during periods of high exertion exercise the dual indicated rate generally corresponds to the metabolic indicated rate.

16. The pacing system of claim 15, wherein the control unit limits the magnitude of the activity indicated rate to a preselected maximum value when the determined magnitude of the activity indicated rate would exceed the preselected maximum value, such that when the magnitude of the metabolic indicated rate exceeds the preselected maximum value for magnitude of the activity indicated rate, the control unit sets the dual indicated rate as corresponding to the metabolic indicated rate.

17. The pacing system of claim 16, wherein the control unit sets the magnitude of the dual indicated rate to the preselected maximum value for the activity indicated rate when the magnitude of the metabolic indicated rate is less than the magnitude of the preselected maximum value for the activity indicated rate and the determined magnitude of the activity indicated rate would exceed the preselected maximum value.

18. The system of claim 17, wherein the preselected maximum value of the magnitude of the activity indicated rate is set by a treating physician at implantation of the pacing system into the patient.

19. The system of claim 17, wherein the preselected maximum value of the magnitude of the activity indicated rate (CAIR) is determined according to the following formula:

20. The system of claim 11, wherein the control unit evaluates the activity signal and the metabolic signal and determines whether either the metabolic signal or the activity signal indicates that the patient is at rest and, if the patient is determined to be at rest, the control unit then sets the dual indicated rate to correspond to a predetermined rest rate.

21. The system of claim 20, wherein the control unit sets the dual indicating rate as corresponding to a rest rate that is equal to the larger of the activity indicated rate or the metabolic indicated rate when both the activity indicated rate and the metabolic indicated rate are indicating that the patient is at rest.

22. The system of claim 21, wherein the control unit sets the dual indicated rate as corresponding to a rest rate that is equal to one of the activity indicated rates or the metabolic indicated rate when one of the activity indicated rates or the metabolic indicated rate is indicating that the patient is at rest.

23. The system of claim 11, wherein the control unit determines whether the magnitude of the activity indicated rate is less than a first preselected threshold value when the metabolic indicated rate exceeds a second preselected threshold value and sets the dual indicated rate as corresponding to an intermediate value selected to be between the magnitude of the metabolic indicated rate and the activity indicated rate.

24. The system of claim 23, wherein the control unit successively sets the dual indicated rate to correspond to an intermediate value between the magnitude of the activity indicated rate and the magnitude of the metabolic indicated rate until the magnitude of the metabolic indicated rate is less than the second preselected threshold value so that during periods following high exertion exercise the dual indicated rate is more gradually lowered.

25. A method of determining a pacing rate of a heart of a patient, the method comprising:

sensing an activity parameter of the patient comprising sensing the acceleration of the patient'"'"'s body to obtain an indication of the level of activity of the patient;

sensing a metabolic parameter of the patient;

determining an activity indicated rate based upon the sensed activity parameter of the patient;

determining a metabolic indicated rate based upon the sensed metabolic parameter of the patient; and

setting a dual indicated rate to be the greater of the activity indicated rate or the metabolic indicated rate, wherein the dual indicated rate corresponds to the rate at which the heart rate of the heart of the patient is to be maintained to meet the metabolic needs of the patient based upon the sensed activity and metabolic parameters.

26. The method of claim 25, further comprising scaling the activity indicated rate and the metabolic indicated rate so that the activity indicated rate and the metabolic indicated rate correspond to each other.

27. The method of claim 25, wherein sensing a metabolic parameter of the patient comprises sensing the transthoracic impedance of the patient to obtain a minute ventilation parameter indicative of the metabolic demand of the patient.

28. The method of claim 27, wherein setting a dual indicated rate to be the greater of the activity indicated rate or the metabolic indicated rate comprises setting the dual indicated rate to be the metabolic indicated rate when the metabolic indicated rate exceeds the preselected maximum of the activity indicated rate.

29. The method of claim 28, wherein setting the dual indicated rate to be the greater of the activity indicated rate or the metabolic indicated rate comprises setting the dual indicated rate to be the preselected maximum of the activity indicated rate when the metabolic indicated rate is less than the preselected maximum and the activity indicated rate would exceed the preselected maximum.

30. A pacing system comprising:

a plurality of independently functioning rate sensors, said plurality comprising activity rate sensor means and metabolic sensor means;

the activity rate sensor means, functioning independently from the metabolic sensor means, for generating an activity indicated rate signal dependent upon the sensed activity of the patient;

the metabolic rate sensor means, functioning independently from the activity rate sensor means, for generating a metabolic indicated rate signal dependent upon a metabolic demand of the patient in response to physical activity of the patient;

dual indicated rate determining means for determining, based upon the activity indicated rate signal and the metabolic indicated rate signal, a dual indicated rate for pacing the patient, wherein the dual indicated rate determining means sets the dual indicated rate to correspond to the greater of the activity indicated rate signal or the metabolic indicated rate signal; and

pacing means for providing pacing signals to the heart of the patient in response to the dual indicated rate.

31. The system of claim 30, further comprising means for setting the dual indicated rate as corresponding to a rest rate when either the activity indicated rate signal or the metabolic indicated rate signal indicates that the patient is at rest.

32. The system of claim 31, further comprising means for setting the dual indicated rate as corresponding to a rest rate that is equal to the larger of the activity indicated rate signal or the metabolic indicated rate signal when both the activity indicated rate signal and the metabolic indicated rate signal are indicating that the patient is at rest.

33. The system of claim 32, further comprising means for setting the dual indicated rate as corresponding to a rest rate that is equal to one of the activity indicated rate signal or the metabolic indicated rate signal when one of the activity indicated rate signals or the metabolic indicated rate signal is indicating that the patient is at rest.

34. The system of claim 30, wherein the activity rate sensor means comprises an activity sensor that senses acceleration of the patient'"'"'s body in response to activity of the patient and generates the activity indicated rate signal therefrom.

35. The system of claim 30, wherein the metabolic rate sensor means comprises a transthoracic impedance measurement circuit that periodically obtains a transthoracic impedance measurement which is then used to determine a minute ventilation parameter upon which the metabolic indicated rate signal is based.

36. The system of claim 30, further comprising means for determining whether the activity indicated rate signal is less than a preselected threshold value when the metabolic indicated rate signal exceeds a preselected threshold value and sets the dual indicated rate as being equal to an intermediate value selected to be between the metabolic indicated rate signal and the activity indicated rate signal.

37. The system of claim 36, including means for continuing to set the dual indicated rate at an intermediate value until the metabolic indicated rate signal decreases below the preselected threshold so that the pacing signals are provided to the heart at a progressively slower rate.

38. A method of determining a pacing rate of a heart of a patient, the method comprising the steps of:

sensing an activity parameter of the patient;

sensing a metabolic parameter of the patient;

determining an activity indicated rate based upon the sensed activity parameter of the patient;

determining whether the activity indicated rate exceeds a preselected maximum rate;

setting the activity indicated rate to the preselected maximum rate when the activity indicated rate exceeds the preselected maximum rate;

determining a metabolic indicated rate based upon the sensed metabolic parameter of the patient; and

setting a dual indicated rate to be the greater of the metabolic indicated rate and the activity indicated rate, wherein the dual indicated rate corresponds to the rate at which the heart rate of the heart of the patient is to be maintained to meet the metabolic needs of the patient based upon the sensed activity and metabolic parameters.

39. A method of determining a pacing rate of a heart of a patient, the method comprising the steps of:

sensing an activity parameter of the patient

sensing a metabolic parameter of the patient;

determining an activity indicated rate based upon the sensed activity parameter of the patient;

determining a metabolic indicated rate based upon the sensed metabolic parameter of the patient; and

determining whether the activity indicated rate is less than a preselected threshold value when the metabolic indicated rate exceeds a preselected threshold value and wherein setting a dual indicated rate, when the activity indicated rate is less than a preselected threshold value and when the metabolic indicated rate exceeds a preselected value, comprises setting the dual indicated rate to an intermediate value which is between the metabolic indicated rate and the activity indicated rate to thereby slow the heart rate more slowly, wherein the dual indicated rate corresponds to the rate at which the heart rate of the heart of the patient is to be maintained to meet the metabolic needs of the patient based upon the sensed activity and metabolic parameters.

40. A method of determining a pacing rate of a heart of a patient, the method comprising the steps of:

sensing an activity parameter of the patient;

sensing a metabolic parameter of the patient;

determining an activity indicated rate based upon the sensed activity parameter of the patient;

determining a metabolic indicated rate based upon the sensed metabolic parameter of the patient;

determining whether the activity indicated rate or the metabolic indicated rate indicates that the patient is at rest; and

setting a dual indicated rate to a rest rate when it is determined that the patient is at rest, otherwise setting the dual indicated rate to be the greater of the activity indicated rate or the metabolic indicated rate, wherein the dual indicated rate corresponds to the rate at which the heart rate of the heart of the patient is to be maintained to meet the metabolic needs of the patient based upon the sensed activity and metabolic parameters.