Image quality based adaptive optimization of computer aided detection schemes

• US 6,278,793 B1
• Filed: 07/17/1998
• Issued: 08/21/2001
• Est. Priority Date: 11/02/1995
• Status: Expired due to Fees

• Current Assignee: University Of Pittsburgh (University of Pittsburgh of The Commonwealth System of Higher Education)
• Original Assignee: University Of Pittsburgh (University of Pittsburgh of The Commonwealth System of Higher Education)
• Inventors: Zheng, Bin, Gur, David
• Primary Examiner(s): Bella, Matthew C.
• Assistant Examiner(s): CHOOBIN, BARRY
• Application Number:
  US09/118,366
• Time in Patent Office: 1,131 Days
• Field of Search: 382/133, 382/132, 382/128, 382/130
• US Class Current: 382/128
• CPC Class Codes: G06T 2207/10116 X-ray image
• CPC Class Codes: G06T 2207/30068 Mammography; Breast
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06V 10/25 Determination of region of interest [ROI] or a volume of interest [VOI]

Abstract

A computerized method of detecting regions of interest in a digital image optimizes and adapts a computer aided scheme for detecting regions of interest in images. The optimization is based on global image characteristics. For each image in a database of images having known regions of interest, global image features are measured and an image characteristic index is established based on these global image features. All the images in the database are divided into a number of image groups based on the image characteristic index of each image in the database and the CAD scheme is optimized for each image group. Once the CAD scheme is optimized, to process a digital image, an image characteristics based classification criteria is established for that image, and then global image features of the digitized image are determined. The digitized image is then assigned an image characteristics rating based on the determined global image features, and the image is assigned to an image group based on the image rating. Then regions of interest depicted in the image are determined using a detection scheme adapted for the assigned image group.

Claims

1. A method of detecting regions of interest in a digital image, comprising the steps of, by computer:

determining global image features of the digitized image;

assigning the digitized image an image characteristics rating based on the determined global image features;

assigning the image to an image group based on the image rating; and

detecting regions of interest depicted in the image using a detection scheme optimized specifically for the assigned image group.

2. A method as in claim 1, wherein said images are radiographs and wherein said regions of interest are abnormal regions in living tissue depicted in said radiographs.

3. A method as in claim 1, wherein the radiograph is a mammogram, and wherein the abnormal regions are masses.

4. A method as in claim 1, wherein the radiograph is a mammogram, and wherein the abnormal regions are clustered microcalcifications.

5. A method as in claim 1, wherein the step of assigning assigns the image to one of three groups.

6. A method as in claim 2, wherein said computer aided detection scheme comprises the steps of:

(a) digitizing the radiograph to produce a digitized radiograph;

and, by computer,

(b) identifying, according to predetermined criteria, any suspected abnormal regions; and

(c) for each identified suspected abnormal region,

(i) extracting multiple topographic layers of the region from the digitized radiograph; and

(ii) evaluating the extracted multiple topographic layers of abnormal regions to determine whether the region is an abnormal region.