Magnetic resonance imaging
First Claim
1. A method of studying tissue metabolism comprising:
- acquiring a first magnetic resonance image of tissue of interest;
delivering oxygen, predominantly in the form of oxygen-16, to the tissue of interest;
acquiring a second magnetic resonance image of the tissue of interest after the delivery of the oxygen; and
comparing the first and second images to determine the effect of the delivery of the oxygen on the tissue.
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Accused Products
Abstract
The present invention is a method of studying tissue metabolism with ordinary oxygen. First, a magnetic resonance image of the tissue of interest is acquired. Oxygen, predominantly in the form of oxygen-16, is then delivered to the tissue. A magnetic resonance image of the tissue of interest is then acquired when the tissue is in the state of increased oxygenation. The first and second images are compared to determine the effect of the delivery of oxygen on the tissue based on changes in image characteristics, such as image contrast, image intensity and the morphology of tissues in the image. A relative measure of the degree of tissue oxygenation before and after the delivery of oxygen may be determined. The oxygen may be administered by inhalation of gaseous oxygen. The tissue may also be directly perfused by gaseous oxygen. The oxygen may be administered in combination with an oxygen carrier molecule, such as hemoglobin or heme. Preferably, only trace amounts of oxygen-17 is present. Oxygen substantially in its naturally occurring isotopic preparations is preferably delivered.
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Citations
17 Claims
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1. A method of studying tissue metabolism comprising:
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acquiring a first magnetic resonance image of tissue of interest;
delivering oxygen, predominantly in the form of oxygen-16, to the tissue of interest;
acquiring a second magnetic resonance image of the tissue of interest after the delivery of the oxygen; and
comparing the first and second images to determine the effect of the delivery of the oxygen on the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of studying tissue metabolism comprising:
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acquiring a first magnetic resonance image of tissue of interest;
delivering oxygen, substantially in its naturally occurring isotopic proportions, to the tissue of interest through inhalation;
acquiring a second magnetic resonance image of the tissue of interest after the delivery of the oxygen; and
comparing the first and second images to determine the effect of the delivery of the oxygen on the tissue.
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13. A method of studying tissue metabolism comprising:
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acquiring a first magnetic resonance image of tissue of interest;
delivering oxygen, substantially in its naturally occurring isotopic proportions, to the tissue of interest in combination with an oxygen carrier molecule;
acquiring a second magnetic resonance image of the tissue of interest after the delivery of the oxygen; and
comparing the first and second images to determine the effect of the delivery of the oxygen on the tissue. - View Dependent Claims (14, 15)
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16. A method of studying tissue metabolism comprising:
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acquiring a first magnetic resonance image of tissue of interest;
delivering oxygen, substantially in its naturally occurring isotopic proportions, to the tissue of interest by perfusion;
acquiring a second magnetic resonance image of the tissue of interest after the delivery of the oxygen; and
comparing the first and second images to determine the effect of the delivery of the oxygen on the tissue. - View Dependent Claims (17)
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Specification