Thrombolytic filtration and drug delivery catheter with a self-expanding portion

• US 6,280,413 B1
• Filed: 07/08/1997
• Issued: 08/28/2001
• Est. Priority Date: 06/07/1995
• Status: Expired due to Fees

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Inventors: Clark, Souise S., Chornenky, Victor I., Clark, David W., Forman, Michael R., Lee, Jeffrey A.
• Primary Examiner(s): Yasko, John D.
• Application Number:
  US08/889,432
• Time in Patent Office: 1,512 Days
• Field of Search: 604/104, 604/95-97, 604/99, 604/49, 604/51, 604/280-282, 604/264, 604/27, 604/28
• US Class Current: 604/104
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/0071 Multiple separate lumens multiple separate lumens throughout the catheter A61M25/0026
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool

Abstract

A thrombolytic filtration and drug delivery catheter is disclosed comprising a shaft which longitudinal ribs. The ribs are compressed while being advanced to the site of interest and are released at the site, flaring to a diameter greater than the diameter of the shaft. The ribs can be compressed by a sleeve or thread, for example. Drugs or other agents can be delivered through lumens in the shaft and ribs, out through ports in the ribs. Preferably, the ports are positioned to deliver the drugs or other agents between the ribs and within the region defined by the ribs.

Claims

1. A catheter comprising:

a shaft with a proximal and distal portion, the distal portion comprising longitudinal ribs which in a first position flare beyond the diameter of the shaft;

means for compressing the longitudinal ribs such that when the means for compressing is released from the longitudinal ribs, the longitudinal ribs flare to the first position; and

delivery conduits extending longitudinally through the shaft and ribs and at least one port in each rib for a delivered drug or agent to exit each rib.

2. The catheter of claim 1, wherein the ports are located on an outer periphery of each rib.

3. The catheter of claim 1, wherein the ports are located on sides of each rib.

4. The catheter of claim 1, wherein the ports are located on an underside of each rib.

5. A catheter comprising:

a shaft with a proximal and distal portion, the distal portion comprising a plurality of longitudinal ribs which in a first position flare beyond the diameter of the shaft, the shaft further comprising delivery lumens extending longitudinally through the shaft and ribs and at least one port in each rib for a delivered drug or agent to exit each rib; and

a sleeve receiving at least the distal portion of the shaft, wherein the sleeve and shaft can move with respect to each other such that when the sleeve is retracted from the distal portion, the longitudinal ribs are in their first position and when the distal portion is within the sleeve, the member compresses the ribs into a second position.

6. The catheter of claim 5, wherein the ports are located on an outer periphery of each rib.

7. The catheter of claim 5, wherein the ports are located on sides of each rib.

8. The catheter of claim 5, wherein the ports are located on an underside of each rib.

9. The catheter of claim 5, further comprising a plurality of ports located on the outer periphery, sides and underside of each rib.

10. The catheter of claim 5, wherein the shaft further comprises a guide wire lumen.

11. The catheter of claim 5, wherein the ribs are adapted to bear against a lumen wall when released within a lumen.

12. A catheter comprising:

a shaft with a proximal and distal portion, the distal portion comprising a plurality of longitudinal ribs which in a first position flare beyond the diameter of the shaft, the shaft further comprising delivery conduits extending longitudinally through the shaft and ribs and at least one port in each rib for a delivered drug or agent to exit each rib; and

thread tied about the longitudinal ribs to compress the ribs in a second position such that when the thread is released from the distal portion, the longitudinal ribs flare into their first position.

13. The catheter of claim 12, wherein the ports are located on an outer periphery of each rib.

14. The catheter of claim 12, wherein the ports are located on sides of each rib.

15. The catheter of claim 12, wherein the ports are located on an underside of each rib.

16. The catheter of claim 12, further comprising a plurality of ports on the outer periphery, sides and undersides of each rib.

17. The catheter of claim 12, further comprising a guide wire lumen.

18. The catheter of claim 12, wherein the ribs are adapted to bear against a lumen wall when released within a lumen.

19. A method of delivering drugs or other agents within a lumen by a catheter comprising:

advancing the catheter with compressed, expandable-hollow, longitudinal ribs to a desired site within the lumen;

releasing the compressed longitudinal ribs, to allow the expandable longitudinal ribs to flare beyond the diameter of the shaft; and

delivering drugs or other agents to the site through the longitudinal ribs.

20. The method of claim 19, wherein the ribs bear against the walls of the lumen when flared.

21. The method of claim 19, further comprising delivering the drugs or other agents proximate the wall of the lumen.

22. The method of claim 19, further comprising delivering the drugs or other agents to a region between the longitudinal ribs.

24. The method of claim 19, wherein the longitudinal ribs are compressed by a sleeve and the releasing step comprises retracting the sleeve.

25. The method of claim 19, wherein different drugs or other agents are delivered through different longitudinal ribs.

28. The method of claim 25, further comprising delivering the lytic agent to the vessel.

23. The method of 19, further comprising delivering the drugs or other agents to a region within the longitudinal ribs.

26. A method of filtering thrombolytic material from a vessel within the cardiovascular system comprising:

advancing a catheter to a desired site within the vessel;

retracting a portion of the catheter to allow a plurality of compressed longitudinal ribs in the distal portion of the catheter to flare beyond the diameter of the catheter to contact the lumen; and

delivering drugs or other agents out of the catheter through the ribs.

27. The method of claim 26, wherein the delivering step comprises delivering a lytic agent.

29. The method of claim 26, further comprising delivering the lytic agent to a region between the longitudinal ribs.

30. The method of claim 26, further comprising delivering the lytic agent to a region within the longitudinal ribs.

31. The method of claim 26, wherein different drugs or other agents are delivered through different longitudinal ribs.

32. A catheter comprising:

a shaft with a proximal and distal portion, the distal portion comprising longitudinal ribs which in a first position flare beyond the diameter of the shaft;

a thread for compressing the longitudinal ribs such that when the thread is released from the longitudinal ribs, the longitudinal ribs flare to the first position; and

means for delivering drugs to the longitudinal ribs.

33. A catheter comprising:

a shaft with a proximal and distal portion, the distal portion comprising logitudinal ribs which in a first position flare beyond the diameter of the shaft;

a member receiving at least the distal portion of the shaft, wherein the member and shaft can move with respect to each other such that when the member is retracted from the distal portion, the longitudinal ribs are in the first position and when the distal portion is within the member, the member compresses the longitudinal ribs into a second position; and

means for delivering drugs or other agents to the longitudinal ribs.

34. The catheter of claim 33, wherein the member is a sleeve extending over the proximal and distal portions of the shaft.

35. A catheter comprising:

a shaft with a proximal and distal portion, the distal portion comprising filtration means which in a first position flares beyond the diameter of the shaft;

means for compressing the filtration means such that when the means for compressing is released from the filtration means the filtration means flares to the first position, so that the filtration means bears against walls of a lumen when released at a site; and

means for delivering drugs or other agents to the filtration means.