Nicotine lozenge

• US 6,280,761 B1
• Filed: 05/15/1996
• Issued: 08/28/2001
• Est. Priority Date: 07/26/1993
• Status: Expired due to Term

• Current Assignee: McNeil AB (Johnson & Johnson)
• Original Assignee: Pharmacia AB (Pharmacia Corp.)
• Inventors: Santus, Gian Carlo
• Primary Examiner(s): VENKAT, JYOTHSNA A
• Application Number:
  US08/644,971
• Time in Patent Office: 1,931 Days
• Field of Search: 424/440, 424/435
• US Class Current: 424/435
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/465 Nicotine; Derivatives thereof
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 25/34 Tobacco-abuse

Abstract

A method for smoking cessation therapy is described that utilizing an improved nicotine lozenge to satisfy transient craving. The lozenge contains nicotine, a nonnutritive sweetener and an absorbent excipient.

Claims

1. A nicotine lozenge consisting of 1 mg nicotine, 200 mg mannitol, 1309 mg xylitol, 20 mg mint flavor, 15 mg ammonium glycyrrhizinate, 5 mg sodium carbonate, 15 mg sodium bicarbonate, 25 mg hydrogenated vegetable oil, and 10 mg magnesium stearate.

2. A nicotine lozenge consisting of 1 mg nicotine, 200 mg mannitol, 1316.5 mg xylitol, 6 mg tobacco flavor, 1.5 mg colloidal silica, 15 mg ammonium glycyrrhizinate, 5 mg sodium carbonate, 15 mg sodium bicarbonate, 30 mg hydrogenated vegetable oil, and 10 mg magnesium stearate.

3. A nicotine lozenge consisting of 1 mg nicotine, 109 mg betacyclodextrin, 10 mg water, 1400 mg xylitol, 20 mg mint flavor, 15 mg ammonium glycyrrhizinate, 5 mg sodium carbonate, 15 mg sodium bicarbonate, 25 mg hydrogenated vegetable oil, and 10 mg magnesium stearate.