Local drug delivery injection catheter

• US 6,283,947 B1
• Filed: 07/13/1999
• Issued: 09/04/2001
• Est. Priority Date: 07/13/1999
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Mirzaee, Daryush
• Primary Examiner(s): Kennedy, Sharon
• Assistant Examiner(s): Lam, Ann Y.
• Application Number:
  US09/352,628
• Time in Patent Office: 784 Days
• Field of Search: 604/96, 604/192, 604/194, 604/523, 604/264, 604/103.01, 604/103.02, 604/104-109, 604/500, 604/506, 604/508, 604/509
• US Class Current: 604/264
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0086 the needles having bent tips, i.e. the needle distal tips are angled in relation to the longitudinal axis of the catheter
• CPC Class Codes: A61M 2025/0087 Multiple injection needles protruding laterally from the distal tip
• CPC Class Codes: A61M 2025/0096 being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A catheter for injecting medication to a specific point within a patient comprises a drug delivery lumen extending from a proximal end of the catheter to an injection port. The catheter comprises a mechanism for angularly pushing the injection port outwardly away from the body of the catheter into an artery wall so that medication can be injected directly into the artery wall.

Claims

1. A catheter for delivering a drug to a location within a patient, comprising:

a first tube;

a second tube extending from a proximal end to a distal end along an axis;

a first lumen provided in said first tube for receiving said drug, said first lumen extending from the proximal end of said first tube to an injection port;

a preferential bending point on said first tube;

a balloon lumen provided in said second tube; and

a balloon coupled to the balloon lumen such that inflation of the balloon bends the first tube at the preferential bending point, thereby angularly pushing said injection port away from the axis of the second tube to change an angle formed between said injection port and said axis of the second tube.

2. Catheter of claim 1 wherein said injection port comprises a needle.

3. Catheter of claim 1 wherein said injection port is radiopaque.

4. Catheter of claim 1 wherein a radiopaque marker is provided on said balloon.

5. Catheter of claim 1 wherein a radiopaque marker is formed on said catheter proximate to said balloon.

6. Catheter of claim 1 wherein a radiopaque marker is provided on said first tube at said preferential bending point where said injection port bends away from said axis of said second tube.

7. Catheter of claim 1 further comprising a stiffening mandrel extending through said first lumen.

8. Catheter of claim 1 further comprising a stiffening mandrel extending along the exterior of said first tube.

9. Catheter of claim 1 wherein said balloon is a helical-shaped balloon.

10. Catheter of claim 1 wherein said balloon has wide and narrow regions to permit blood to perfuse past said balloon when said balloon is inflated.

11. Catheter of claim 1, further comprising a guide wire lumen having an axis parallel to the axis of the second tube.

12. A catheter for delivering a drug to a location within a patient comprising:

a first tube;

a second tube extending from a proximal end to a distal end along an axis;

a first lumen provided in said first tube for receiving said drug, said first lumen extending from the proximal end of said first tube to an injection port;

a preferential bending point on said first tube;

a balloon lumen provided in said second tube; and

a balloon coupled to the balloon lumen such that inflation of the balloon bends the first tube at the preferential bending point, thereby rotating said injection port away from the axis of the second tube.

13. Catheter of claim 12, further comprising a guide wire lumen having an axis parallel to the axis of the second tube.

14. Method for delivering medication to a patient comprising the steps of:

inserting a catheter into a patient, said catheter comprising a catheter body, a drug delivery lumen within the catheter body, and an injection port in communication with said drug delivery lumen;

inflating a balloon to angularly push the injection port away from the catheter axis toward or into the patient'"'"'s artery wall by bending said drug delivery lumen at a preferential bending point; and

injecting medication into the patient through the drug delivery lumen and said injection port.

15. Method of claim 14 wherein said injection port is a needle.

16. Method of claim 14 further comprising the steps of:

moving said injection port toward an angle parallel with the axis of said catheter after said step of injecting; and

retracting said catheter.

17. A catheter for delivering a drug to a location within a patient, comprising:

a guide wire lumen;

a tube extending from a proximal end to a distal end along an axis of said guide wire lumen and having a first lumen for receiving said drug, said first lumen extending from the proximal end of said tube to an injection port;

a preferential bending point on said tube; and

a balloon for angularly pushing said injection port away from the axis of the guide wire lumen by bending said tube at said preferential bending point, thereby changing an angle formed between said injection port and said axis of the guide wire lumen;

said injection port being coupled to said tube at said preferential bending point.

18. Catheter of claim 17 wherein said injection port comprises a needle.

19. Catheter of claim 17 further comprising a stiffening mandrel extending through said tube.

20. Catheter of claim 17 wherein a stiffening mandrel extends along an exterior of said tube.

21. A catheter for delivering a drug to a location within a patient, comprising:

a guide wire lumen;

a tube extending from a proximal end to a distal end along an axis of said guide wire lumen and having a first lumen for receiving said drug, said first lumen extending from the proximal end of said tube to an injection port;

a preferential bending point on said tube; and

an inflatable balloon for rotating said injection port away from the axis of the guide wire lumen by bending said tube at said preferential bending point;

said injection port being coupled to said tube at said preferential bending point.

22. Catheter of claim 21 wherein said injection port comprises a needle.

23. Catheter of claim 21 further comprising a stiffening mandrel extending through said tube.

24. Catheter of claim 21 wherein a stiffening mandrel extends along an exterior of said tube.

25. Method for delivering medication to a patient comprising the steps of:

inserting a catheter into a patient, said catheter comprising a catheter body, a guide wire lumen having an axis, a tube, a drug delivery lumen within the tube, and an injection port in communication with said drug delivery lumen;

angularly extending the injection port away from the axis of the guide wire lumen toward or into the patient'"'"'s artery wall by inflating a balloon to bend said tube at a preferential bending point, said injection port being attached to said tube at said preferential bending point, to change an angle formed between said injection port and said axis of the guide wire lumen; and

injecting medication into the patient through the drug delivery lumen and said injection port.

26. Method of claim 25 wherein said injection port comprises a needle.

27. Method of claim 25, further comprising the steps of:

moving said injection port toward an angle parallel with said axis of the guide wire lumen after said step of injecting; and

retracting said catheter.