Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing

• US 6,284,142 B1
• Filed: 09/03/1999
• Issued: 09/04/2001
• Est. Priority Date: 09/03/1999
• Status: Expired due to Fees

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Muller, Matthew R.
• Primary Examiner(s): Drodge, Joseph W.
• Application Number:
  US09/389,912
• Time in Patent Office: 732 Days
• Field of Search: 210/85, 210/94, 210/96.1, 210/143, 210/258, 210/645, 210/739, 210/745, 210/767, 210/787, 210/512.1, 210/789, 494/10, 494/37, 604/4.01, 604/5.01, 604/6.11, 417/1, 417/14, 417/18, 356/39, 422/82.05, 250/227.11, 333/81.R
• US Class Current: 210/745
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/302 having a reservoir for withdrawn untreated blood
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/308 Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
• CPC Class Codes: A61M 1/362227 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/362261 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362262 Details of incorporated reservoirs
• CPC Class Codes: A61M 1/362264 the filter being a blood filter
• CPC Class Codes: A61M 1/362265 Details of valves
• CPC Class Codes: A61M 1/362266 Means for adding solutions or substances to the blood
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: B01D 17/0217 by centrifugal force
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence

Abstract

Systems and related methods sense the presence of targeted cellular blood species during extracorporeal blood separation or processing. The systems and methods tailor the sensing parameters to the particular objectives of the blood processing procedure selected to be accomplished. Different cellular blood species are targeted for detection for different selected blood processing procedures. The systems and methods differentiate among different cellular blood species for detection, according to the blood processing procedure selected.

Claims

1. A blood processing system comprising

a blood separation chamber constructed and arranged for rotation about an axis separate blood into a plasma layer and an adjoining region comprising different first and second cellular blood species arranged in layers according to density,

a collection line including a pump to remove the plasma layer from the blood separation chamber, the pump operating to control flow through the collection line in response to pump control signals,

a sensor assembly in the collection line to detect presence of the first or second cellular blood species in the collection line, the sensor assembly including a source of light at a first wavelength, a source of light at a second wavelength different than the first wavelength, the different first and second wavelengths being selected to possess substantially the same optical attenuation for the first cellular blood species and significantly different optical attentuations for the second cellular blood species, a sensor to sense attentuations of light at the first and second wavelengths in the collection line, and a module to analyze sensed attenuations of light at the two different wavelengths to differentiate between the presence of the first cellular blood species and the presence of the second cellular blood species in the collection line,

a controller coupled to the sensor assembly and including an input to prompt selection of at least a first blood collection protocol, which harvests plasma substantially free of the first and second cellular blood species, and a second blood collection protocol which harvests plasma containing the first cellular blood species but which is substantially free of the second cellular blood component, the controller operating, when the first blood collection protocol is selected, to generate a pump control signal when the sensor assembly detects presence of the first cellular blood species in the collection line, the controller also operating, when the second collection protocol is selected, to generate a pump control signal when the sensor assembly detects presence of the second cellular blood species in the collection line.

2. A system according to claim 1

wherein the pump control signal reduces or stops flow through the collection line.

3. A system according to claim 1

wherein the first cellular blood species comprises platelets.

4. A system according to claim 1

wherein the second cellular blood species comprises red blood cells.

5. A system according to claim 1

wherein the adjoining region includes a platelet-rich layer and red blood cell-rich layer, and

wherein, when the first blood collection protocol is selected, the controller generates a pump control signal when the sensor assembly detects presence of platelets in the collection line.

6. A system according to claim 1

wherein the adjoining region includes a platelet-rich layer and red blood cell-rich layer, and

wherein, when the second blood collection protocol is selected, the controller generates a pump control signal when the sensor assembly detects presence of red blood cells in the collection line.

7. A system according to claim 1

wherein the adjoining region includes a buffy coat comprising a platelet-rich layer adjoining the plasma layer, and red blood cell-rich layer adjoining the buffy coat layer,

wherein the input prompts selection of a buffy coat collection protocol, and

wherein, when the buffy coat collection protocol is selected, the controller generates one or more pump control signals when the sensor assembly detects either presence of platelets or presence of red blood cells in the collection line.

8. A system according to claim 1

wherein the sensor assembly optically detects concentration of the first and second cellular blood species.

9. A system according to claim 1

wherein the first source of light comprises a first emitter of light at a first wavelength (λ

₁) having a known optical attenuation for platelets at the first wavelength (ε

_platelets^λ

₁) and a known optical attenuation for hemoglobin at the first wavelength (ε

_Hb^λ

₁),

wherein the second source of light comprises a second emitter of light at a second wavelength (λ

₂) having a known optical attenuation for platelets at the second wavelength (ε

_platelets^λ

₂) and a known optical attenuation for hemoglobin at the second wavelength (ε

_Hb^λ

₂),

wherein;

10. A blood processing method comprising the steps of

selecting a blood collection protocol,

separating blood into a plasma layer and an adjoining region comprising different first and second cellular blood species arranged in layers according to density,

removing the plasma layer through a collection line through a pump that is controlled by pump control signals,

optically sensing changes in concentration of the cellular blood species in the collection line using a source of light at a first wavelength, a source of light at a second wavelength different than the first wavelength, the different first and second wavelengths being selected to possess substantially the same optical attenuation for the first cellular blood species and significantly different optical attentuations for the second cellular blood species, a sensor to sense attentuations of light at the first and second wavelengths in the collection line, and a module to analyze sensed attenuations of light at the two different wavelengths by the sensor to differentiate between the presence of the first cellular blood species and the presence of the second cellular blood species in the collection line, and

generating the pump control signals according to the blood collection protocol selected, so that, when a first blood collection protocol is selected, a pump control signal is generated when changes in concentration of the first cellular blood species are detected, and, when a second blood collection protocol is selected, a pump control signal is generated when changes in concentration of the second cellular blood species are detected.

11. A method according to claim 10

wherein the pump control signal reduces or stops flow through the collection line.

12. A method according to claim 10

wherein the first cellular blood species comprises platelets.

13. A method according to claim 10

wherein the second cellular blood species comprises red blood cells.

14. A method according to claim 10

wherein the adjoining region includes a platelet-rich layer and red blood cell-rich layer, and

wherein, when a plasma collection protocol is selected, a pump control signal is generated when changes in concentration of platelets are detected.

15. A method according to claim 10

wherein the adjoining region includes a platelet-rich layer and red blood cell-rich layer, and

wherein, when a red blood cell collection protocol is selected, a pump control signal is generated when changes in concentration of red blood cells are detected.

16. A method according to claim 10

wherein the adjoining region includes a buffy coat comprising a platelet-rich layer adjoining the plasma layer, and red blood cell-rich layer adjoining the buffy coat layer, and

wherein, when a buffy coat collection protocol is selected, pump control signals are generated based upon detection of changes in concentration of both platelets and red blood cells.