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Optical amplification of molecular interactions using liquid crystals

  • US 6,284,197 B1
  • Filed: 07/31/1998
  • Issued: 09/04/2001
  • Est. Priority Date: 06/05/1998
  • Status: Expired due to Term
First Claim
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1. A method of visually detecting an analyte-recognition moiety complex formed by an interaction between an analyte and a recognition moiety for said analyte by transducing said interaction to an organic mesogenic layer, said method comprising:

  • (a) interacting said analyte with a surface comprising said recognition moiety, thereby forming an analyte-recognition moiety complex, said surface comprising;

    (i) a substrate;

    (ii) a self-assembled organosulfur or oganosilane monolayer bound to substrate; and

    (iii) said recognition moiety bound to said self-assembled monolayer;

    (b) contacting said analyte-recognition moiety complex with said organic mesogenic layer, thereby anchoring said organic mesogenic layer onto said self-assembled monolayer and causing at least a portion of a plurality of mesogens proximate to said recognition moiety to detectably switch from a first orientation to a second orientation, thereby transducing said interaction to said mesogenic layer, said transducing causing said mesogenic layer to register a visually detectable feature; and

    (c) visually detecting said feature.

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