Bioadhesive composition

• US 6,284,235 B1
• Filed: 02/11/2000
• Issued: 09/04/2001
• Est. Priority Date: 02/11/2000
• Status: Expired due to Term

• Current Assignee: Henkel IP & Holding GmbH (Henkel AG & Co KGaA), Universlteit Gent
• Original Assignee: National Starch and Chemical Investment Holding Corporation
• Inventors: Remon, Jean Paul, Richardson, Paul, Ameye, Dieter, Foreman, Paul B., Callens, Catherine, Tsai, John, Voorspoels, Jody
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Di Nola-Baron, Liliana
• Application Number:
  US09/502,585
• Time in Patent Office: 571 Days
• Field of Search: 424/78.08, 424/486, 424/488, 514/778, 514/781, 514/782, 514/783
• US Class Current: 424/78.08
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/2059 Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
• CPC Class Codes: C08J 2300/104 containing oxygen atoms
• CPC Class Codes: C08J 3/246 Intercrosslinking of at least two polymers

Abstract

This invention relates to a method of producing a bioadhesive composition comprising the steps of preparing a solution of a solvent and a polymer mixture wherein the polymer mixture comprises at least one natural or synthetic polycarboxylated polymer and at least one polysaccharide; drying the solution to form a solid; and heat treating the solid to effect cross-linking and to form the bioadhesive composition.

Claims

1. A method of producing a bioadhesive composition comprising preparing a solution of at least one solvent and a polymer mixture wherein the polymer mixture comprises at least one poly(acrylic) acid and at least one starch having a molecular weight of at least 10,000 Daltons;

drying the solution to form a solid; and

heat treating the solid at a temperature and for a time sufficient to effect cross-linking and form a bioadhesive composition.

2. The method of claim 1 wherein the solid is heat treated at a temperature from about 60°

C. to about 200°

C.

3. The method of claim 1 wherein the poly(acrylic) acid is a modified poly(acrylic) acid.

4. The method of claim 1 wherein the solvent is water.

5. The method of claim 2 wherein the solid is heat treated at a temperature from about 80°

C. to about 120°

C.

6. The method of claim 1 wherein the poly(acrylic) acid has a weight average molecular weight of at least 1,000 Daltons.

7. The method of claim 1 wherein the poly(acrylic) acid is a cross-linked poly(acrylic) acid.

8. The method of claim 1 wherein the poly(acrylic) acid is cross-linked by a cross-linking material selected from the group consisting of allyl ethers of sucrose, pentaerythritol, and divinyl glycol.

9. The method of claim 1 wherein the poly(acrylic) acid is present in the polymer mixture in an amount of about 25 percent by weight to about 83 percent by weight.

10. The method of claim 1 wherein the starch is modified by etherification, esterification, acid hydrolysis, dextrinization, crosslinking, pregelatinization or enzyme treatment.