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Method for generating dopaminergic cells derived from neural precursors

  • US 6,284,539 B1
  • Filed: 10/09/1998
  • Issued: 09/04/2001
  • Est. Priority Date: 10/09/1998
  • Status: Expired due to Term
First Claim
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1. A method for generating tyrosine hydroxylase expressing cells in a culture of mammalian CNS stem cells, comprising the steps of:

  • a) culturing mammalian CNS stem cells in vitro;

    b) introducing a polynucleotide that encodes a transcriptional regulator into the mammalian CNS stem cells in the culture, wherein the polynucleotide encodes a transcriptional regulator selected from the group consisting of Nurr1, RNR-1, HZF-3, TINUR, and NOT, and wherein the polynucleotide is expressed;

    c) incubating the mammalian CNS stem cells; and

    d) identifying tyrosine hydroxylase expressing cells in the culture.

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